Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas.

abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

journal_title：Scientific reports

authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

更新日期：2019-07-15 00:00:00

abstract：:The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at appropriate rates. Based on the general structural organizations of the TA, we propose how the TA dynamically orchestrates transcriptional responses. ...

journal_title：Scientific reports

authors： Wang Y,Liu F,Wang W

更新日期：2012-01-01 00:00:00

abstract：:CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of genome editing, phenotyp...

journal_title：Scientific reports

authors： Naert T,Tulkens D,Edwards NA,Carron M,Shaidani NI,Wlizla M,Boel A,Demuynck S,Horb ME,Coucke P,Willaert A,Zorn AM,Vleminckx K

更新日期：2020-09-04 00:00:00

abstract：:We report two brothers from a non-consanguineous Irish family presenting with a novel syndrome characterised by intellectual disability, facial dysmorphism, scoliosis and long QT. Their mother has a milder phenotype including long QT. X-linked inheritance was suspected. Whole exome sequencing identified a novel missen...

journal_title：Scientific reports

authors： Casey JP,Støve SI,McGorrian C,Galvin J,Blenski M,Dunne A,Ennis S,Brett F,King MD,Arnesen T,Lynch SA

更新日期：2015-11-02 00:00:00

abstract：:Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...

journal_title：Scientific reports

authors： Lee S,Barnhill RL,Dummer R,Dalton J,Wu J,Pappo A,Bahrami A

更新日期：2015-06-10 00:00:00

abstract：:The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...

journal_title：Scientific reports

authors： Müller S,Herde L,Preische O,Zeller A,Heymann P,Robens S,Elbing U,Laske C

更新日期：2019-03-05 00:00:00

abstract：:Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules. LncRNAs have been implicated in cancer development and response to different therapeutics and are th...

journal_title：Scientific reports

authors： Sanlorenzo M,Vujic I,Esteve-Puig R,Lai K,Vujic M,Lin K,Posch C,Dimon M,Moy A,Zekhtser M,Johnston K,Gho D,Ho W,Gajjala A,Oses Prieto J,Burlingame A,Daud A,Rappersberger K,Ortiz-Urda S

更新日期：2018-07-19 00:00:00

abstract：:In honeybees fast and efficient exploitation of nectar and pollen sources is achieved by persistent endothermy throughout the foraging cycle, which means extremely high energy costs. The need for food promotes maximisation of the intake rate, and the high costs call for energetic optimisation. Experiments on how honey...

journal_title：Scientific reports

authors： Stabentheiner A,Kovac H

更新日期：2016-06-20 00:00:00

abstract：:Electronic structures of graphene oxide (GO) and hydro-thermally reduced graphene oxides (rGOs) processed at low temperatures (120-180°C) were studied using X-ray absorption near-edge structure (XANES), X-ray emission spectroscopy (XES) and resonant inelastic X-ray scattering (RIXS). C K-edge XANES spectra of rGOs rev...

journal_title：Scientific reports

authors： Chuang CH,Wang YF,Shao YC,Yeh YC,Wang DY,Chen CW,Chiou JW,Ray SC,Pong WF,Zhang L,Zhu JF,Guo JH

更新日期：2014-04-10 00:00:00

abstract：:Human motor skill learning is driven by the necessity to adapt to new situations. While supportive contacts are essential for many tasks, little is known about their impact on motor learning. To study the effect of contacts an innovative full-body experimental paradigm was established. The task of the subjects was to ...

journal_title：Scientific reports

authors： Rueckert E,Čamernik J,Peters J,Babič J

更新日期：2016-06-22 00:00:00

abstract：:Concurrent chemoradiation therapy (CCRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD-1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CCRT on programmed ...

journal_title：Scientific reports

authors： Fujimoto D,Uehara K,Sato Y,Sakanoue I,Ito M,Teraoka S,Nagata K,Nakagawa A,Kosaka Y,Otsuka K,Imai Y,Hamakawa H,Takahashi Y,Kokubo M,Tomii K

更新日期：2017-09-12 00:00:00

abstract：:Lariatin A, an 18-residue lasso peptide encoded by the five-gene cluster larABCDE, displays potent and selective anti-mycobacterial activity. The structural feature is an N-terminal macrolactam ring, through which the C-terminal passed to form the rigid lariat-protoknot structure. In the present study, we established ...

journal_title：Scientific reports

authors： Inokoshi J,Koyama N,Miyake M,Shimizu Y,Tomoda H

更新日期：2016-07-26 00:00:00

abstract：:Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was down-regulated in Kmmig1. Consistently, introduction of HIS4 ...

journal_title：Scientific reports

authors： Nurcholis M,Murata M,Limtong S,Kosaka T,Yamada M

更新日期：2019-07-09 00:00:00

abstract：:Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...

journal_title：Scientific reports

authors： Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F

更新日期：2013-12-19 00:00:00

abstract：:This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcriptio...

journal_title：Scientific reports

authors： Al Bkhetan Z,Plewczynski D

更新日期：2018-03-26 00:00:00

abstract：:This study was to investigate the association between dietary patterns and rhinitis in primary school children. 1,599 students without rhinitis at baseline survey were selected from a primary school children cohort. Information on food consumption, respiratory symptoms, and confounders was collected using questionnair...

journal_title：Scientific reports

authors： Liu X,Wong CC,Yu IT,Zhang Z,Tan L,Lau AP,Lee A,Yeoh EK,Lao XQ

更新日期：2017-03-15 00:00:00

abstract：:Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents...

journal_title：Scientific reports

authors： Rees JA,Deblonde GJ,An DD,Ansoborlo C,Gauny SS,Abergel RJ

更新日期：2018-03-13 00:00:00

abstract：:The fine-tuning of gene expression contributes to both basic science and applications. Here, we develop a novel gene expression technology termed CRITGI (CRISPR/Transposon gene integration). CRITGI uses CRISPR/Cas9 to integrate multiple copies of the plasmid pTy1 into Ty1 loci, budding yeast retrotransposons. The pTy1...

journal_title：Scientific reports

authors： Hanasaki M,Masumoto H

更新日期：2019-10-25 00:00:00

abstract：:Radiation exposure during muscle development induces long-term decrements to skeletal muscle health, which contribute to reduced quality of life in childhood cancer survivors. Whether the effects of radiation on skeletal muscle are influenced by relevant physiological factors, such as obesity and exercise training rem...

journal_title：Scientific reports

authors： D'Souza D,Roubos S,Larkin J,Lloyd J,Emmons R,Chen H,De Lisio M

更新日期：2019-04-30 00:00:00

abstract：:Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...

journal_title：Scientific reports

authors： Lu D,Mao C,Cho SK,Ahn S,Park W

更新日期：2016-01-07 00:00:00

abstract：:During germ cell development, epigenetic modifications undergo extensive remodeling. Abnormal epigenetic modifications usually result in germ cell loss and reproductive defect. Prmt5 (Protein arginine methyltransferase 5) encodes a protein arginine methyltransferase which has been demonstrated to play important roles ...

journal_title：Scientific reports

authors： Wang Y,Zhu T,Li Q,Liu C,Han F,Chen M,Zhang L,Cui X,Qin Y,Bao S,Gao F

更新日期：2015-06-15 00:00:00

abstract：:We describe a novel method to achieve a universal, massive, and fully automated analysis of cell motility behaviours, starting from time-lapse microscopy images. The approach was inspired by the recent successes in application of machine learning for style recognition in paintings and artistic style transfer. The orig...

journal_title：Scientific reports

authors： Mencattini A,Di Giuseppe D,Comes MC,Casti P,Corsi F,Bertani FR,Ghibelli L,Businaro L,Di Natale C,Parrini MC,Martinelli E

更新日期：2020-05-06 00:00:00

abstract：:The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...

journal_title：Scientific reports

authors： Roos J,Enlund E,Funcke JB,Tews D,Holzmann K,Debatin KM,Wabitsch M,Fischer-Posovszky P

更新日期：2016-12-06 00:00:00

abstract：:Porous carbon spheres (CSs) have distinct advantages in energy storage and conversion applications. We report the preparation of highly monodisperse N-doped microporous CSs through the carbonization of polystyrene-based polymer spheres and subsequent activation. The N-doped microporous CSs have a remarkably high N-dop...

journal_title：Scientific reports

authors： Kim C,Kim K,Moon JH

更新日期：2017-10-31 00:00:00

abstract：:The progression of pulmonary fibrosis (PF) entails a complex network of interactions between multiple classes of molecules and cells, which are closely related to the vagus nerve. Stimulation of the vagus nerve increases fibrogenic cytokines in humans, therefore, activation of the nerve may promote PF. The hypothesis ...

journal_title：Scientific reports

authors： Song N,Liu J,Shaheen S,Du L,Proctor M,Roman J,Yu J

更新日期：2015-08-20 00:00:00

abstract：:Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...

journal_title：Scientific reports

authors： Usuki F,Fujimura M,Yamashita A

更新日期：2017-09-28 00:00:00

abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

journal_title：Scientific reports

authors： Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

更新日期：2016-08-22 00:00:00

abstract：:Fish reproductive success is linked to the ability of couples to mate and produce clutches that successfully hatch. Environmental stressors like high temperature and low pH can jeopardize this energetically costly process. In this study, exposure to high temperature and low pH was tested on a marine temperate species,...

journal_title：Scientific reports

authors： Lopes AF,Faria AM,Dupont S

更新日期：2020-11-30 00:00:00

abstract：:Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...

journal_title：Scientific reports

authors： Zhao YR,Li X,Yu KQ,Cheng F,He Y

更新日期：2016-06-10 00:00:00

abstract：:Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...

journal_title：Scientific reports

authors： Lyons WB,Deuerling K,Welch KA,Welch SA,Michalski G,Walters WW,Nielsen U,Wall DH,Hogg I,Adams BJ

更新日期：2016-05-18 00:00:00