MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus.

abstract：:Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the...

journal_title：Scientific reports

authors： Yoon EJ,Choi JS,Kim H,Sohn BK,Jung HY,Lee JY,Kim DJ,Park SW,Kim YK

更新日期：2017-07-18 00:00:00

abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

journal_title：Scientific reports

authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

更新日期：2017-07-26 00:00:00

abstract：:Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...

journal_title：Scientific reports

authors： Liang S,Hurteau MD,Westerling AL

更新日期：2017-05-25 00:00:00

abstract：:The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets i...

journal_title：Scientific reports

authors： Li X,Wu Y,Li J,Li Y,Long L,Li F,Wu G

更新日期：2015-01-05 00:00:00

abstract：:Increasing evidence has confirmed that immunoglobulins (Igs) can be expressed in non-B cells. Our previous work demonstrated that mesangial cells and podocytes express IgA and IgG, respectively. The aim of this work was to reveal whether proximal tubular epithelial cells (PTECs) express Igs. High-throughput single-cel...

journal_title：Scientific reports

authors： Deng Z,Wang X,Liu Y,Tian X,Deng S,Sun Y,Wang S,Zheng D,Cui Z,Pan Y,A L,Yan H,Qiu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these p...

journal_title：Scientific reports

authors： Zhao C,Li X,Hu H

更新日期：2016-07-20 00:00:00

abstract：:The roles of multifunctional CD4 T cells in human tuberculosis are not well defined. In this study, we found that patients with tuberculosis had decreased PMA/ionomycin stimulated multifunctional CD4 T cells, and increased Mycobacterium tuberculosis antigen-specific multifunctional CD4 T cells, when compared to indivi...

journal_title：Scientific reports

authors： Qiu Z,Zhang M,Zhu Y,Zheng F,Lu P,Liu H,Graner MW,Zhou B,Chen X

更新日期：2012-01-01 00:00:00

abstract：:Grain boundary (GB) oxidation of proton-irradiated 304 nuclear grade stainless steel in primary water of pressurized water reactor was investigated. The investigation was conducted by studying microstructure of the oxide and oxide precursor formed at GB on an "atom-by-atom" basis by a combination of atom-probe tomogra...

journal_title：Scientific reports

authors： Deng P,Peng Q,Han EH

更新日期：2021-01-14 00:00:00

abstract：:A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of ...

journal_title：Scientific reports

authors： Ottosson H,Nylén F,Sarker P,Miraglia E,Bergman P,Gudmundsson GH,Raqib R,Agerberth B,Strömberg R

更新日期：2016-11-09 00:00:00

abstract：:The PRL phosphatases are oncogenic when overexpressed but their in vivo biological function is less well understood. Previous gene deletion study revealed a role for PRL2 in spermatogenesis. We report here the first knockout mice lacking PRL1, the most related homolog of PRL2. We found that loss of PRL1 does not affec...

journal_title：Scientific reports

authors： Bai Y,Zhou HM,Zhang L,Dong Y,Zeng Q,Shou W,Zhang ZY

更新日期：2016-09-26 00:00:00

abstract：:H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how chronic inflammation triggers gastric carcinogenesis is still not clear. In this study, neutrophils and relative markers in gastric cancer development were examined with immunohistochemistry and fluo...

journal_title：Scientific reports

authors： Fu H,Ma Y,Yang M,Zhang C,Huang H,Xia Y,Lu L,Jin W,Cui D

更新日期：2016-07-14 00:00:00

abstract：:Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have reinvigorated interest on GDH regulation, which remains poorly understood despite...

journal_title：Scientific reports

authors： Bera S,Rashid M,Medvinsky AB,Sun GQ,Li BL,Acquisti C,Sljoka A,Chakraborty A

更新日期：2020-10-05 00:00:00

abstract：:A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi fil...

journal_title：Scientific reports

authors： Zhang DX,Yoshikawa C,Welch NG,Pasic P,Thissen H,Voelcker NH

更新日期：2019-02-04 00:00:00

abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...

journal_title：Scientific reports

authors： Jessel HR,Chen S,Osovski S,Efroni S,Rittel D,Bachelet I

更新日期：2019-03-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Essaidi-Laziosi M,Geiser J,Huang S,Constant S,Kaiser L,Tapparel C

更新日期：2020-07-22 00:00:00

abstract：:Pellagra is a photosensitivity syndrome characterized by three "D's": diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a...

journal_title：Scientific reports

authors： Sugita K,Ikenouchi-Sugita A,Nakayama Y,Yoshioka H,Nomura T,Sakabe J,Nakahigashi K,Kuroda E,Uematsu S,Nakamura J,Akira S,Nakamura M,Narumiya S,Miyachi Y,Tokura Y,Kabashima K

更新日期：2013-10-17 00:00:00

abstract：:Autophagy is known to be implicated in the pathogenesis of Sjögren syndrome (SS), but evidences are limited. We aimed to examine the levels of autophagy markers in tear film and conjunctival epithelial cells from SS dry eye patients, and analyze their correlations with clinical features. Patients with SS dry eye exhib...

journal_title：Scientific reports

authors： Byun YS,Lee HJ,Shin S,Chung SH

更新日期：2017-12-08 00:00:00

abstract：:Recent reports have demonstrated the role of phyto-constituents in modulating inflammatory responses. Mangiferin isolated from Mangifera indica is known to induce potent anti-oxidative, anti-diabetic and anti-inflammatory activity. However, the molecular mechanism of its anti-inflammatory activity is not properly unde...

journal_title：Scientific reports

authors： Bulugonda RK,Kumar KA,Gangappa D,Beeda H,Philip GH,Muralidhara Rao D,Faisal SM

更新日期：2017-02-20 00:00:00

abstract：:N-linked glycosylation is one of the predominant post-translational modifications involved in a number of biological functions. Since experimental characterization of glycosites is challenging, glycosite prediction is crucial. Several predictors have been made available and report high performance. Most of them evalua...

journal_title：Scientific reports

authors： Pitti T,Chen CT,Lin HN,Choong WK,Hsu WL,Sung TY

更新日期：2019-11-04 00:00:00

abstract：:In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...

journal_title：Scientific reports

authors： Khoshroo A,Fattahi A

更新日期：2020-09-03 00:00:00

abstract：:Charge densities of iso-structural metal hexaborides, a transparent metal LaB6 and a semiconductor BaB6, have been determined using the d > 0.22 Å ultra-high resolution synchrotron radiation X-ray diffraction data by a multipole refinement and a maximum entropy method (MEM). The quality of the experimental charge dens...

journal_title：Scientific reports

authors： Kasai H,Nishibori E

更新日期：2017-01-25 00:00:00

abstract：:In this paper, we study the influence of the fingerprint and sweat on the fingerprint on the friction between the hand and an object. When sweat contacts a finger or an object, it is sometimes easy to pick up the object. In particular, we can see this phenomenon when grasping a thin object such as paper and vinyl. The...

journal_title：Scientific reports

authors： Kim D,Yun D

更新日期：2019-11-12 00:00:00

abstract：:Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a compreh...

journal_title：Scientific reports

authors： Wang K,Wu D,Zhang H,Das A,Basu M,Malin J,Cao K,Hannenhalli S

更新日期：2018-07-19 00:00:00

abstract：:This retrospective study was undertaken to provide more modern data of real-life management of non-metastatic rectal cancer, to compare therapeutic strategies, and to identify prognostic factors of overall survival (OS) in a large cohort of patients. Data on efficacy and on acute/late toxicity were retrospectively col...

journal_title：Scientific reports

authors： Langrand-Escure J,Diao P,Garcia MA,Wang G,Guy JB,Espenel S,Guillaume E,Rehailia-Blanchard A,Pigné G,de Laroche G,Kaczmarek D,Muron T,Porcheron J,Phelip JM,Vallard A,Magné N

更新日期：2018-07-16 00:00:00

abstract：:Quantum coherence is one of the old but always important concepts in quantum mechanics, and now it has been regarded as a necessary resource for quantum information processing and quantum metrology. However, the question of how to quantify the quantum coherence has just been paid the attention recently (see, e.g., Bau...

journal_title：Scientific reports

authors： Feng XN,Wei LF

更新日期：2017-11-14 00:00:00

abstract：:Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts to improve commercial breeds. As a step toward this goal we identifie...

journal_title：Scientific reports

authors： Yurchenko AA,Daetwyler HD,Yudin N,Schnabel RD,Vander Jagt CJ,Soloshenko V,Lhasaranov B,Popov R,Taylor JF,Larkin DM

更新日期：2018-08-28 00:00:00

abstract：:Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...

journal_title：Scientific reports

authors： Chmyrov A,Leutenegger M,Grotjohann T,Schönle A,Keller-Findeisen J,Kastrup L,Jakobs S,Donnert G,Sahl SJ,Hell SW

更新日期：2017-03-20 00:00:00

abstract：:Eurasian Jay (Garrulus glandarius) feathers display periodic variations in the reflected colour from white through light blue, dark blue and black. We find the structures responsible for the colour are continuous in their size and spatially controlled by the degree of spinodal phase separation in the corresponding reg...

journal_title：Scientific reports

authors： Parnell AJ,Washington AL,Mykhaylyk OO,Hill CJ,Bianco A,Burg SL,Dennison AJ,Snape M,Cadby AJ,Smith A,Prevost S,Whittaker DM,Jones RA,Fairclough JP,Parker AR

更新日期：2015-12-21 00:00:00

abstract：:Reliable P wave detection is necessary for accurate and automatic electrocardiogram (ECG) analysis. Currently, methods for P wave detection in physiological conditions are well-described and efficient. However, methods for P wave detection during pathology are not generally found in the literature, or their performanc...

journal_title：Scientific reports

authors： Maršánová L,Němcová A,Smíšek R,Vítek M,Smital L

更新日期：2019-12-13 00:00:00

abstract：:Natural killer (NK) cells play a major role in anti-viral immunity as first line defense during hepatitis B infection, particularly in untreated patients whose T cells functions are profoundly impaired. Cytokine interferon (IFN)-γ and tumor necrosis factor (TNF)-α produced by NK cells are important anti-viral factors....

journal_title：Scientific reports

authors： Li X,Gu Y,Guo X,Gu L,Zhou L,Wu X,Wang X,Stamataki Z,Huang Y

更新日期：2017-07-19 00:00:00