Abstract：
:Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents (GBCAs) for MRI, prompting the European Medicines Agency to recommend discontinuing the use of over half of the GBCAs currently approved for clinical applications. To address this problem, we find that the orally-available metal decorporation agent 3,4,3-LI(1,2-HOPO) demonstrates superior efficacy at chelating and removing Gd from the body compared to diethylenetriaminepentaacetic acid, a ligand commonly used in the United States in the GBCA Gadopentetate (Magnevist). Using the radiotracer 153Gd to obtain precise biodistribution data, the results herein, supported by speciation simulations, suggest that the prophylactic or post-hoc therapeutic use of 3,4,3-LI(1,2-HOPO) may provide a means to mitigate Gd retention in patients requiring contrast-enhanced MRI.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rees JA,Deblonde GJ,An DD,Ansoborlo C,Gauny SS,Abergel RJdoi
10.1038/s41598-018-22511-6subject
Has Abstractpub_date
2018-03-13 00:00:00pages
4419issue
1issn
2045-2322pii
10.1038/s41598-018-22511-6journal_volume
8pub_type
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