A novel three-axis cylindrical hohlraum designed for inertial confinement fusion ignition.

abstract：:Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gene transfer efficiency, low immunogenicity, stable long-term expressio...

journal_title：Scientific reports

authors： Kimura T,Ferran B,Tsukahara Y,Shang Q,Desai S,Fedoce A,Pimentel DR,Luptak I,Adachi T,Ido Y,Matsui R,Bachschmid MM

更新日期：2019-09-19 00:00:00

abstract：:A better understanding of the structure and extent of genetic variability in a breeding population of a crop is essential for translating genetic diversity to genetic gain. We assessed the nature and pattern of genetic variability and differentiation in a panel of 100 winged-yam (Dioscorea alata) accessions using 24 p...

journal_title：Scientific reports

authors： Agre P,Asibe F,Darkwa K,Edemodu A,Bauchet G,Asiedu R,Adebola P,Asfaw A

更新日期：2019-12-03 00:00:00

abstract：:Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystallization and molecular...

journal_title：Scientific reports

authors： Liu T,Guo P,Zhou Y,Wang J,Chen L,Yang H,Qian X,Yang Q

更新日期：2014-08-26 00:00:00

abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...

journal_title：Scientific reports

authors： Ansari AA,Adil SF,Alam M,Ahmad N,Assal ME,Labis JP,Alwarthan A

更新日期：2020-09-14 00:00:00

abstract：:Recreational boating is an increasing activity in coastal areas and its spatiotemporal overlap with key habitats of marine species pose a risk for negative noise impacts. Yet, recreational vessels are currently unaccounted for in vessel noise models using Automatic Identification System (AIS) data. Here we conduct a c...

journal_title：Scientific reports

authors： Hermannsen L,Mikkelsen L,Tougaard J,Beedholm K,Johnson M,Madsen PT

更新日期：2019-10-29 00:00:00

abstract：:In recent years, the topic of noise in the sea and its effects on marine mammals has attracted considerable attention from both the scientific community and the general public. Since marine mammals rely heavily on acoustics as a primary means of communicating, navigating, and foraging in the ocean, any change in their...

journal_title：Scientific reports

authors： Frisk GV

更新日期：2012-01-01 00:00:00

abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...

journal_title：Scientific reports

authors： Huang L,Liu P,Yuan Z,Zhou T,Yu J

更新日期：2017-10-03 00:00:00

abstract：:The PDZ domain-containing scaffold protein, syntenin-1, binds to the transmembrane proteoglycan, syndecan-4, but the molecular mechanism/function of this interaction are unknown. Crystal structure analysis of syntenin-1/syndecan-4 cytoplasmic domains revealed that syntenin-1 forms a symmetrical pair of dimers anchored...

journal_title：Scientific reports

authors： Choi Y,Yun JH,Yoo J,Lee I,Kim H,Son HN,Kim IS,Yoon HS,Zimmermann P,Couchman JR,Cho HS,Oh ES,Lee W

更新日期：2016-11-10 00:00:00

abstract：:Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to directly treat the diagnostic materials to cells, multiple steps to optimize dose concentration and treatment time are necessary due to diversity i...

journal_title：Scientific reports

authors： Park KS,Shin SW,Jang MS,Shin W,Yang K,Min J,Cho SW,Oh BK,Bae JW,Jung S,Choi JW,Um SH

更新日期：2015-12-18 00:00:00

abstract：:Widely regarded as an imminent threat to our oceans, ocean acidification has been documented in all oceanic basins. Projected changes in seawater chemistry will have catastrophic biotic effects due to ocean acidification hindering biogenic carbonate production, which will in turn lead to substantial changes in marine ...

journal_title：Scientific reports

authors： Fox L,Stukins S,Hill T,Miller CG

更新日期：2020-01-31 00:00:00

abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

journal_title：Scientific reports

authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

更新日期：2016-02-10 00:00:00

abstract：:Laparoscopic cholecystectomy (LC) is the standard technique for treatment of gallbladder disease. In case of acute cholecystitis we can identify preoperative factors associated with an increased risk of conversion and intraoperative complications. The aim of our study was to detect preoperative laboratory and radiolog...

journal_title：Scientific reports

authors： Di Buono G,Romano G,Galia M,Amato G,Maienza E,Vernuccio F,Bonventre G,Gulotta L,Buscemi S,Agrusa A

更新日期：2021-01-28 00:00:00

abstract：:We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...

journal_title：Scientific reports

authors： Feng S,Zhang J,Su W,Bai S,Xiao L,Chen X,Lin J,Reddy RM,Chang AC,Beer DG,Chen G

更新日期：2017-06-07 00:00:00

abstract：:Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (VHHs) to the N-terminus of a human collagen XVIII trimerization domain (TIE(XVIII)) we produced monospecific...

journal_title：Scientific reports

authors： Alvarez-Cienfuegos A,Nuñez-Prado N,Compte M,Cuesta AM,Blanco-Toribio A,Harwood SL,Villate M,Merino N,Bonet J,Navarro R,Muñoz-Briones C,Sørensen KM,Mølgaard K,Oliva B,Sanz L,Blanco FJ,Alvarez-Vallina L

更新日期：2016-06-27 00:00:00

abstract：:The Hurst effect plays an important role in many areas such as physics, climate and finance. It describes the anomalous growth of range and constrains the behavior and predictability of these systems. The Hurst effect is frequently taken to be synonymous with Long-Range Dependence (LRD) and is typically assumed to be ...

journal_title：Scientific reports

authors： Franzke CL,Osprey SM,Davini P,Watkins NW

更新日期：2015-03-13 00:00:00

abstract：:Increased connectivity with the mainland has led to the arrival of many invasive species to the Galápagos Islands, including novel pathogens, threatening the archipelago's unique fauna. Here we consider the potential role of the mosquito Aedes taeniorhynchus in maintaining the flavivirus West Nile virus [WNV] should i...

journal_title：Scientific reports

authors： Eastwood G,Goodman SJ,Cunningham AA,Kramer LD

更新日期：2013-01-01 00:00:00

abstract：:Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...

journal_title：Scientific reports

authors： Kuwatani T,Nagata K,Okada M,Watanabe T,Ogawa Y,Komai T,Tsuchiya N

更新日期：2014-11-17 00:00:00

abstract：:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers...

journal_title：Scientific reports

authors： Kanodia P,Kaur G,Coshic P,Chatterjee K,Neeman T,George A,Rath S,Bal V,Prabhu SB

更新日期：2019-10-14 00:00:00

abstract：:There is a significant need to develop antibacterial materials that could be applied locally and directly to the places surrounded by large amount of bacteria, in order to address the problems of bacterial antibiotic-resistance or irreversible biofilm formation. Hydrogels are thought to be suitable candidates due to t...

journal_title：Scientific reports

authors： Xu C,Cai Y,Ren C,Gao J,Hao J

更新日期：2015-01-13 00:00:00

abstract：:The synaptic protein SHANK3 encodes a multidomain scaffold protein expressed at the postsynaptic density of neuronal excitatory synapses. We previously identified de novo SHANK3 mutations in patients with autism spectrum disorders (ASD) and showed that SHANK3 represents one of the major genes for ASD. Here, we analyze...

journal_title：Scientific reports

authors： Gouder L,Vitrac A,Goubran-Botros H,Danckaert A,Tinevez JY,André-Leroux G,Atanasova E,Lemière N,Biton A,Leblond CS,Poulet A,Boland A,Deleuze JF,Benchoua A,Delorme R,Bourgeron T,Cloëz-Tayarani I

更新日期：2019-01-14 00:00:00

abstract：:Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post v...

journal_title：Scientific reports

authors： Mold M,Shardlow E,Exley C

更新日期：2016-08-12 00:00:00

abstract：:Al substitution in hematite is ubiquitous in soils. With the increase of Al amount, the hematite morphology changes from rhombohedral crystals to disk-shaped ones, but the underlying mechanism is poorly understood. Herein, a series of Al-substituted hematite were synthesized and characterized by synchrotron X-ray diff...

journal_title：Scientific reports

authors： Li W,Liang X,An P,Feng X,Tan W,Qiu G,Yin H,Liu F

更新日期：2016-10-27 00:00:00

abstract：:The present study aimed to determine the effect of thyroid hormone dysfunction on brown adipose tissue activity and white adipose tissue browning in mice. Twenty randomized female C57BL/6NTac mice per treatment group housed at room temperature were rendered hypothyroid or hyperthyroid. In-vivo small animal 18F-FDG PET...

journal_title：Scientific reports

authors： Weiner J,Kranz M,Klöting N,Kunath A,Steinhoff K,Rijntjes E,Köhrle J,Zeisig V,Hankir M,Gebhardt C,Deuther-Conrad W,Heiker JT,Kralisch S,Stumvoll M,Blüher M,Sabri O,Hesse S,Brust P,Tönjes A,Krause K

更新日期：2016-12-12 00:00:00

abstract：:Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...

journal_title：Scientific reports

authors： Ghita M,McMahon SJ,Taggart LE,Butterworth KT,Schettino G,Prise KM

更新日期：2017-03-16 00:00:00

abstract：:Layered-structure materials are currently relevant given their quasi-2D nature. Knowledge of their physical properties is currently of major interest. Niobium ditelluride possesses a monoclinic layered-structure with a distortion in the tellurium planes. This structural complexity has hindered the determination of its...

journal_title：Scientific reports

authors： Barajas-Aguilar AH,Irwin JC,Garay-Tapia AM,Schwarz T,Paraguay Delgado F,Brodersen PM,Prinja R,Kherani N,Jiménez Sandoval SJ

更新日期：2018-11-19 00:00:00

abstract：:Nano-suspensions (NS) exhibit unusual thermophysical behaviors once interparticle aggregations and the shear flows are imposed, which occur ubiquitously in applications but remain poorly understood, because existing theories have not paid these attentions but focused mainly on stationary NS. Here we report the critica...

journal_title：Scientific reports

authors： Sui J,Zhao P,Bin-Mohsin B,Zheng L,Zhang X,Cheng Z,Chen Y,Chen G

更新日期：2016-12-20 00:00:00

abstract：:The effective differentiation between multiple primary lung tumors (MPs) and intrapulmonary metastases (IMs) in patients is imperative to discover the exact disease stage and to select the most appropriate treatment. In this study, the authors was to evaluate the efficacy and validity of large-scale targeted sequencin...

journal_title：Scientific reports

authors： Duan J,Ge M,Peng J,Zhang Y,Yang L,Wang T,Qin T,Yuan R,Zhang Y,Cheng W

更新日期：2020-11-02 00:00:00

abstract：:Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg1MDW), which overexpress this neurosensory-specific miRNA cluster in the inner ear, were developed as...

journal_title：Scientific reports

authors： Weston MD,Tarang S,Pierce ML,Pyakurel U,Rocha-Sanchez SM,McGee J,Walsh EJ,Soukup GA

更新日期：2018-02-23 00:00:00

abstract：:3β-Hydroxysteroid-Δ24 reductase (DHCR24), the final enzyme of the cholesterol biosynthetic pathway, has been associated with urogenital neoplasms. However, the function of DHCR24 in endometrial cancer (EC) remains largely elusive. Here, we analyzed the expression profile of DHCR24 and the progesterone receptor (PGR) i...

journal_title：Scientific reports

authors： Dai M,Zhu XL,Liu F,Xu QY,Ge QL,Jiang SH,Yang XM,Li J,Wang YH,Wu QK,Ai ZH,Teng YC,Zhang ZG

更新日期：2017-01-23 00:00:00

abstract：:The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...

journal_title：Scientific reports

authors： Fujikura K

更新日期：2016-03-02 00:00:00