A mouse model of miR-96, miR-182 and miR-183 misexpression implicates miRNAs in cochlear cell fate and homeostasis.

abstract：:Vertical mixing modulates nutrient dynamics in lakes. However, surface warming reduces the range of vertical mixing and the probability of full circulation events. Important consequences of reduced vertical mixing include the sequestration of phosphorus (P) within a stagnant zone and the promotion of oligotrophication...

journal_title：Scientific reports

authors： Lau MP,Valerio G,Pilotti M,Hupfer M

更新日期：2020-07-31 00:00:00

abstract：:Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...

journal_title：Scientific reports

authors： Peng L,Sun J,Liu Y,Dai X,Ni BJ

更新日期：2017-04-03 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Park JH,Choi S,Moon HC,Seo H,Kim JY,Hong SP,Lee BS,Kang E,Lee J,Ryu DH,Choi IS

更新日期：2018-12-14 00:00:00

abstract：:Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or ...

journal_title：Scientific reports

authors： Cao H,Ma W

更新日期：2017-03-23 00:00:00

abstract：:Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...

journal_title：Scientific reports

authors： Niu L,Virani S,Bilheem S,Sriplung H

更新日期：2019-11-15 00:00:00

abstract：:Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression of TIE-1 was va...

journal_title：Scientific reports

authors： Ishibashi M,Toyoshima M,Zhang X,Hasegawa-Minato J,Shigeta S,Usui T,Kemp CJ,Grandori C,Kitatani K,Yaegashi N

更新日期：2018-09-04 00:00:00

abstract：:The synthesis and subsequent genomic integration of DNA that is complementary to the genomes of non-retroviral RNA viruses are rarely observed. However, upon infection of various human cell lines and primary fibroblasts with the vesicular stomatitis virus (VSV), we detected DNA complementary to the VSV RNA. The VSV DN...

journal_title：Scientific reports

authors： Shimizu A,Nakatani Y,Nakamura T,Jinno-Oue A,Ishikawa O,Boeke JD,Takeuchi Y,Hoshino H

更新日期：2014-05-30 00:00:00

abstract：:We design a soft infrared metamaterial absorber based on gold nanorods dispersed in liquid crystal (LC) placed on a gold film and theoretically investigate its total absorption character. Because the nanorods align with the LC molecule, the gold nanorods/LC hybrid exhibits different permittivity as a function of tilt ...

journal_title：Scientific reports

authors： Su Z,Yin J,Zhao X

更新日期：2015-11-18 00:00:00

abstract：:Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodontal pathogen, Porphyr...

journal_title：Scientific reports

authors： Ilievski V,Toth PT,Valyi-Nagy K,Valyi-Nagy T,Green SJ,Marattil RS,Aljewari HW,Wicksteed B,O'Brien-Simpson NM,Reynolds EC,Layden BT,Unterman TG,Watanabe K

更新日期：2020-06-19 00:00:00

abstract：:A novel three dimensional blood brain barrier (BBB) platform was developed by independently supplying different types of media to separate cell types within a single device. One channel (vascular channel, VC) is connected to the inner lumen of the vascular network while the other supplies media to the neural cells (ne...

journal_title：Scientific reports

authors： Bang S,Lee SR,Ko J,Son K,Tahk D,Ahn J,Im C,Jeon NL

更新日期：2017-08-14 00:00:00

abstract：:One of the most important goals of condensed matter physics is materials by design, i.e. the ability to reliably predict and design materials with a set of desired properties. A striking example is the deterministic enhancement of the superconducting properties of materials. Recent experiments have demonstrated that t...

journal_title：Scientific reports

authors： Smolyaninova VN,Jensen C,Zimmerman W,Prestigiacomo JC,Osofsky MS,Kim H,Bassim N,Xing Z,Qazilbash MM,Smolyaninov II

更新日期：2016-09-23 00:00:00

abstract：:Sleep problems are considered a core symptom of depression. However, there is little information about the comorbidity of sleep problems and depression in low- and middle-income countries (LMICs), and whether sleep problems with depression confer additional risk for decrements in health compared to sleep problems alon...

journal_title：Scientific reports

authors： Stickley A,Leinsalu M,DeVylder JE,Inoue Y,Koyanagi A

更新日期：2019-08-19 00:00:00

abstract：:Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny...

journal_title：Scientific reports

authors： Choo SW,Ang MY,Dutta A,Tan SY,Siow CC,Heydari H,Mutha NV,Wee WY,Wong GJ

更新日期：2015-12-15 00:00:00

abstract：:Increasing human activity along the coast has amplified the extinction risk of inshore delphinids. Informed selection and prioritisation of areas for the conservation of inshore delphinids requires a comprehensive understanding of their distribution and habitat use. In this study, we applied an ensemble species distri...

journal_title：Scientific reports

authors： Hunt TN,Allen SJ,Bejder L,Parra GJ

更新日期：2020-09-01 00:00:00

abstract：:Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...

journal_title：Scientific reports

authors： Puerma E,Orengo DJ,Aguadé M

更新日期：2016-10-26 00:00:00

abstract：:In addition to its role in the treatment of pancreatitis, the serine protease inhibitor nafamostat exhibits a retinal protective effect. However, the exact mechanisms underlying this effect are unknown. In this study, the neuroprotective effects of nafamostat and its orally active derivative sepimostat against excitot...

journal_title：Scientific reports

authors： Fuwa M,Kageyama M,Ohashi K,Sasaoka M,Sato R,Tanaka M,Tashiro K

更新日期：2019-12-31 00:00:00

abstract：:Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

journal_title：Scientific reports

authors： Ha SJ,Moon JH

更新日期：2014-07-09 00:00:00

abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...

journal_title：Scientific reports

authors： Zhong J,Liu W,Kong L,Morais PC

更新日期：2014-10-15 00:00:00

abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...

journal_title：Scientific reports

authors： Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH

更新日期：2016-01-18 00:00:00

abstract：:Venous thromboembolism (VTE) is an important postoperative complication. We investigated and analyzed the current inguinal hernia treatment methods and occurrence of early postoperative VTE in Chinese adults. This study involved data for patients with inguinal hernia hospitalized in 58 general hospitals in mainland Ch...

journal_title：Scientific reports

authors： Wang M,Zhang G,Chen J,Li J,Che Y,Tang J,Li H,Li J,Ma Y

更新日期：2020-07-29 00:00:00

abstract：:The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patien...

journal_title：Scientific reports

authors： Malagnino V,Cerva C,Maffongelli G,Teti E,Foroghi Biland L,Cesta N,De Masi M,Stingone C,Armenia D,Svicher V,Salpini R,Andreoni M,Sarmati L

更新日期：2019-08-16 00:00:00

abstract：:In northern Iceland the European-North American plate boundary is broad and complex but includes a remarkable subaerial triple-junction intersection between the Husavik-Flatey Fault (HFF) dextral transform and rifting in the Northern Volcanic Zone. Fortuitously, the triple junction occurs in a sheet of ~12 ka pahoehoe...

journal_title：Scientific reports

authors： Rust D,Whitworth M

更新日期：2019-07-04 00:00:00

abstract：:Geriatric trauma is a major socio-economic problem, especially among the aging Japanese society. Geriatric people are more vulnerable to trauma than younger people; thus, their outcomes are often severe. This study evaluates the characteristics of geriatric trauma divided by age in the Japanese population. We evaluate...

journal_title：Scientific reports

authors： Miyoshi Y,Kondo Y,Hirano Y,Ishihara T,Sueyoshi K,Okamoto K,Tanaka H

更新日期：2020-11-05 00:00:00

abstract：:Histone deacetylase inhibition (HDACi) has been suggested as a promising approach to bolster TLR-mediated induction of antimicrobial peptides such as human β-defensin 2 (hBD2). In inflammatory bowel disease (IBD), Crohn's disease (CD) patients display an attenuated expression of hBD2 as compared to ulcerative colitis ...

journal_title：Scientific reports

authors： Stebe-Frick S,Ostaff MJ,Stange EF,Malek NP,Wehkamp J

更新日期：2018-08-27 00:00:00

abstract：:NGS (Next Generation Sequencing) technologies allows us to determine key gene expression signatures that correlate with resistance (and responsiveness) to anti-cancer therapeutics. We have undertaken a transcriptomic and chromatin immunoprecipitation followed by sequencing (ChIP-seq) approach to describe differences i...

journal_title：Scientific reports

authors： Nava M,Dutta P,Farias-Eisner R,Vadgama JV,Wu Y

更新日期：2019-03-26 00:00:00

abstract：:Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous works focused on fin...

journal_title：Scientific reports

authors： Hu M,Shen L,Zan X,Shang X,Liu W

更新日期：2016-05-19 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In...

journal_title：Scientific reports

authors： Park HW,Park CG,Park M,Lee SH,Park HR,Lim J,Paek SH,Choy YB

更新日期：2020-06-12 00:00:00

abstract：:Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...

journal_title：Scientific reports

authors： Mahlangeni NT,Moodley R,Jonnalagadda SB

更新日期：2020-06-17 00:00:00

abstract：:Although large populations feel fatigue, the standardized medicinal therapy is currently absent. In this study, we determined whether 5-aminolevulinic acid (5-ALA) supplementation alleviates the feeling of fatigue in healthy subjects who feel chronic physical tiredness. Males and females between ages of 20 and 64 who ...

journal_title：Scientific reports

authors： Higashikawa F,Kanno K,Ogata A,Sugiyama M

更新日期：2020-09-29 00:00:00

abstract：:Molecular dynamics (MD) simulations lasting 500 ns were performed in explicit water to investigate the effect of polarization on the binding of ligands to human α-thrombin based on the standard nonpolarizable AMBER force field and the quantum-derived polarized protein-specific charge (PPC). The PPC includes the electr...

journal_title：Scientific reports

authors： Duan LL,Feng GQ,Zhang QG

更新日期：2016-08-10 00:00:00