Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer.

abstract：:The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the re...

journal_title：Scientific reports

authors： Kou Y,Xu X,Zhu Z,Dai L,Tan Y

更新日期：2020-12-08 00:00:00

abstract：:In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport ...

journal_title：Scientific reports

authors： Kanazawa N,Goto T,Sekiguchi K,Granovsky AB,Ross CA,Takagi H,Nakamura Y,Uchida H,Inoue M

更新日期：2017-08-11 00:00:00

abstract：:Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. live...

journal_title：Scientific reports

authors： Korenčič A,Košir R,Bordyugov G,Lehmann R,Rozman D,Herzel H

更新日期：2014-07-22 00:00:00

abstract：:Transcriptomic analysis showed that the central circadian pathway genes had significantly altered expression in fracture calluses from mice fed a low phosphate diet. This led us to hypothesize that phosphate deficiency altered the circadian cycle in peripheral tissues. Analysis of the expression of the central clock g...

journal_title：Scientific reports

authors： Noguchi T,Hussein AI,Horowitz N,Carroll D,Gower AC,Demissie S,Gerstenfeld LC

更新日期：2018-09-13 00:00:00

abstract：:Diabetes is expected to accelerate age-related ganglion cell-inner plexiform layer (GC-IPL) loss, but there is limited information on the rate of reduction in GC-IPL thicknesses. We aimed to evaluate the reduction rate of GC-IPL thickness in diabetic patients, and to compare the rates between patients without and with...

journal_title：Scientific reports

authors： Lim HB,Shin YI,Lee MW,Koo H,Lee WH,Kim JY

更新日期：2020-01-30 00:00:00

abstract：:We examined the associations of age and serum magnesium, iron, lead, copper, and zinc levels with bone mineral density (BMD) in 2412 children under 3 years of age in order to find a tool to monitor BMD in children without the use of expensive imaging techniques. One-way ANOVA and chi-square tests were used to determin...

journal_title：Scientific reports

authors： Wu Z,Yuan Y,Tian J,Long F,Luo W

更新日期：2021-01-21 00:00:00

abstract：:Oviposition site-selection in insects is mediated through innate recognition templates (IRTs) tuned to specific chemical cues. These cues aid gravid insects in choosing suitable oviposition sites and may even enhance the fitness of their offspring by warding off predators and parasitoids. However, studies on the evolu...

journal_title：Scientific reports

authors： Damodaram KJ,Kempraj V,Aurade RM,Rajasekhar SB,Venkataramanappa RK,Nandagopal B,Verghese A

更新日期：2014-12-15 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Lee SH,Ryu S,Lee JY,Seo DC,Kim BJ,Sung KC

更新日期：2019-06-05 00:00:00

abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...

journal_title：Scientific reports

authors： Spadacenta S,Dicke PW,Thier P

更新日期：2019-10-25 00:00:00

abstract：:Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as...

journal_title：Scientific reports

authors： Pletsch-Borba L,Grafetstätter M,Hüsing A,González Maldonado S,Kloss M,Groß ML,Johnson T,Sookthai D,Bugert P,Kaaks R,Kühn T

更新日期：2019-02-28 00:00:00

abstract：:This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients w...

journal_title：Scientific reports

authors： Kamiya K,Kobashi H,Igarashi A,Shoji N,Shimizu K

更新日期：2016-04-18 00:00:00

abstract：:Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-ce...

journal_title：Scientific reports

authors： Munakata Y,Yamada T,Imai J,Takahashi K,Tsukita S,Shirai Y,Kodama S,Asai Y,Sugisawa T,Chiba Y,Kaneko K,Uno K,Sawada S,Hatakeyama H,Kanzaki M,Miyazaki JI,Oka Y,Katagiri H

更新日期：2018-01-24 00:00:00

abstract：:MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3'untranslated regions of its target genes. Machine learning based miRNA target prediction algorithms first extract a set of features from potential binding sites (PBSs) in the mRNA and then train a classifier to distinguish targets from no...

journal_title：Scientific reports

authors： Bandyopadhyay S,Ghosh D,Mitra R,Zhao Z

更新日期：2015-01-23 00:00:00

abstract：:Human corneal endothelial cells (HCECs) easily become fibroblastic-like when cultured, rendering them unsuitable for tissue engineering of the cornea. Transforming growth factor β (TGF-β) could be a key factor in this phenomenon; however, TGF-β is also known to maintain the endothelium in a quiescent state in vivo. Th...

journal_title：Scientific reports

authors： Beaulieu Leclerc V,Roy O,Santerre K,Proulx S

更新日期：2018-03-13 00:00:00

abstract：:This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...

journal_title：Scientific reports

authors： Roy S,Liu HY,Jaeson MI,Deimel LP,Ranasinghe C

更新日期：2020-01-23 00:00:00

abstract：:An appropriate tillage method must be implemented by maize growers to improve phosphorus dynamics in the soil in order to increase phosphorus uptake by plant. The objective of this study was to investigate the effects of tillage systems on phosphorus and its fractions in rhizosphere and non-rhizosphere soils under mai...

journal_title：Scientific reports

authors： Xomphoutheb T,Jiao S,Guo X,Mabagala FS,Sui B,Wang H,Zhao L,Zhao X

更新日期：2020-04-20 00:00:00

abstract：:In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associat...

journal_title：Scientific reports

authors： Watanabe T,Wang X,Tan Z,Frahm J

更新日期：2019-03-25 00:00:00

abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

journal_title：Scientific reports

authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

更新日期：2015-06-10 00:00:00

abstract：:Inflammatory reactions activated by pattern recognition receptors (PRRs) on the membrane of innate immune cells play an important role in atherosclerosis. Whether the PRRs of the C-type lectin receptor (CLR) family including Dectin-2 may be involved in the pathogenesis of atherosclerosis remains largely unknown. Recen...

journal_title：Scientific reports

authors： Thiem K,Hoeke G,van den Berg S,Hijmans A,Jacobs CWM,Zhou E,Mol IM,Mouktaroudi M,Bussink J,Kanneganti TD,Lutgens E,Stienstra R,Tack CJ,Netea MG,Rensen PCN,Berbée JFP,van Diepen JA

更新日期：2019-03-13 00:00:00

abstract：:Abnormal cardiac fibrosis indicates cardiac dysfunction and poor prognosis in myocardial infarction (MI) patients. Many studies have demonstrated that the ubiquitin proteasome system (UPS) plays a significant role in the pathogenesis of fibrosis. Ubiquitin C-terminal hydrolase L1 (UCHL1), a member of the UPS, is relat...

journal_title：Scientific reports

authors： Lei Q,Yi T,Li H,Yan Z,Lv Z,Li G,Wang Y

更新日期：2020-06-30 00:00:00

abstract：:The structure of bonds in biomolecules, such as base pairs in RNA chains or native interactions in proteins, can be presented in the form of a chord diagram. A given biomolecule is then characterized by the genus of an auxiliary two-dimensional surface associated to such a diagram. In this work we introduce the notion...

journal_title：Scientific reports

authors： Zając S,Geary C,Andersen ES,Dabrowski-Tumanski P,Sulkowska JI,Sułkowski P

更新日期：2018-12-03 00:00:00

abstract：:CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and ...

journal_title：Scientific reports

authors： Wu G,Sun Y,Wang K,Chen Z,Wang X,Chang F,Li T,Feng P,Xia Z

更新日期：2016-07-22 00:00:00

abstract：:The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(-)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse...

journal_title：Scientific reports

authors： Fang YW,Yang SS,Cheng CJ,Tseng MH,Hsu HM,Lin SH

更新日期：2016-01-05 00:00:00

abstract：:Enterovirus A71 (EV-A71), which belongs to the family Picornaviridae, can invade the central nervous system (CNS) and cause severe CNS complications or death. The EV-A71 antigen has been detected in the neurons in the brains of humans who died from EV-A71 infection. However, the effect of EV-A71 infection on human neu...

journal_title：Scientific reports

authors： Lin JY,Huang HI

更新日期：2020-09-17 00:00:00

abstract：:Multifunctional nanocarriers harbouring specific targeting moieties and with pH-responsive properties offer great potential for targeted cancer therapy. Several synthetic drug carriers have been studied extensively as drug delivery systems but not much information is available on the application of virus-like nanopart...

journal_title：Scientific reports

authors： Biabanikhankahdani R,Alitheen NBM,Ho KL,Tan WS

更新日期：2016-11-24 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Saldaña L,Vallés G,Bensiamar F,Mancebo FJ,García-Rey E,Vilaboa N

更新日期：2018-03-06 00:00:00

abstract：:Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright fiel...

journal_title：Scientific reports

authors： Dubey V,Popova D,Ahmad A,Acharya G,Basnet P,Mehta DS,Ahluwalia BS

更新日期：2019-03-05 00:00:00

abstract：:Vaccine trials and cohort studies in Plasmodium falciparum endemic areas indicate that naturally-acquired and vaccine-induced antibodies to merozoite surface protein 2 (MSP2) are associated with resistance to malaria. These data indicate that PfMSP2 has significant potential as a component of a multi-antigen malaria v...

journal_title：Scientific reports

authors： Eacret JS,Gonzales DM,Franks RG,Burns JM Jr

更新日期：2019-06-21 00:00:00

abstract：:Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-e...

journal_title：Scientific reports

authors： Wu W,Wagner EK,Hao Y,Rao X,Dai H,Han J,Chen J,Storniolo AMV,Liu Y,He C

更新日期：2016-09-06 00:00:00

abstract：:Meteorite impacts have caused catastrophic perturbations to the global environment and mass extinctions throughout the Earth's history. Here, we present petrographic and geochemical evidence of a possible impact ejecta layer, dating from about 11 Ma, in deep-sea clayey sediment in the Northwest Pacific. This clay laye...

journal_title：Scientific reports

authors： Nozaki T,Ohta J,Noguchi T,Sato H,Ishikawa A,Takaya Y,Kimura JI,Chang Q,Shimada K,Ishibashi JI,Yasukawa K,Kimoto K,Iijima K,Kato Y

更新日期：2019-11-20 00:00:00