Nafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model.

abstract：:A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibit...

journal_title：Scientific reports

authors： Lu L,Wang M,Mao Z,Kang TS,Chen XP,Lu JJ,Leung CH,Ma DL

更新日期：2016-03-02 00:00:00

abstract：:We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1-42), tTau and pTau CSF concentrat...

journal_title：Scientific reports

authors： Blennow K,Shaw LM,Stomrud E,Mattsson N,Toledo JB,Buck K,Wahl S,Eichenlaub U,Lifke V,Simon M,Trojanowski JQ,Hansson O

更新日期：2019-12-13 00:00:00

abstract：:Guanylate binding proteins (GBPs) belongs to the interferons (IFNs) induced guanylate-binding protein family (Guanosine triphosphatases, GTPases) consisting of seven homologous members, termed GBP1 to GBP7. We used multidimensional survey ways to explore GBPs expression, regulation, mutations, immune infiltration and ...

journal_title：Scientific reports

authors： Wu ZH,Cai F,Zhong Y

更新日期：2020-04-08 00:00:00

abstract：:The endoplasmic reticulum (ER) is the main site of protein synthesis in eukaryotic cells and requires a high concentration of luminal chaperones to function. During protein synthesis, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell viability. ER protein retrieval is a...

journal_title：Scientific reports

authors： Wu Z,Newstead S,Biggin PC

更新日期：2020-10-09 00:00:00

abstract：:Due to the different craniocervical structures in humans and cetaceans, a standardised method assessing the normal craniocervical relationship in cetaceans is lacking, causing difficulties in defining the presence of atlanto-occipital dissociation (AOD) in cetaceans. The present study aimed to 1) describe a novel stan...

journal_title：Scientific reports

authors： Kot BCW,Chan DKP,Yuen AHL,Tsui HCL

更新日期：2018-05-31 00:00:00

abstract：:The modern Asian monsoonal systems are currently believed to have originated around the end of the Oligocene following a crucial step of uplift of the Tibetan-Himalayan highlands. Although monsoon possibly drove the evolution of many mammal lineages during the Neogene, no evidence thereof has been provided so far. We ...

journal_title：Scientific reports

authors： López-Antoñanzas R,Knoll F,Wan S,Flynn LJ

更新日期：2015-03-11 00:00:00

abstract：:Steep-slope transistors allow to scale down the supply voltage and the energy per computed bit of information as compared to conventional field-effect transistors (FETs), due to their sub-60 mV/decade subthreshold swing at room temperature. Currently pursued approaches to achieve such a subthermionic subthreshold swin...

journal_title：Scientific reports

authors： Vitale WA,Casu EA,Biswas A,Rosca T,Alper C,Krammer A,Luong GV,Zhao QT,Mantl S,Schüler A,Ionescu AM

更新日期：2017-03-23 00:00:00

abstract：:Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel-Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis in an organ- and cell-specific way. In this study, human liver samples were collected from hepatitis C-, alcoholic-, and cholestatic-associated fibrotic an...

journal_title：Scientific reports

authors： Wang J,Lu Z,Xu Z,Tian P,Miao H,Pan S,Song R,Sun X,Zhao B,Wang D,Ma Y,Song X,Zhang S,Liu L,Jiang H

更新日期：2017-01-23 00:00:00

abstract：:Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the roles of individual regions within more complex asymmetrical cha...

journal_title：Scientific reports

authors： Penny CJ,Rahman T,Sula A,Miles AJ,Wallace BA,Patel S

更新日期：2016-12-12 00:00:00

abstract：:A large volcanic sulfate increase observed in ice core records around 1450 C.E. has been attributed in previous studies to a volcanic eruption from the submarine Kuwae caldera in Vanuatu. Both EPMA-WDS (electron microprobe analysis using a wavelength dispersive spectrometer) and SEM-EDS (scanning electron microscopy a...

journal_title：Scientific reports

authors： Hartman LH,Kurbatov AV,Winski DA,Cruz-Uribe AM,Davies SM,Dunbar NW,Iverson NA,Aydin M,Fegyveresi JM,Ferris DG,Fudge TJ,Osterberg EC,Hargreaves GM,Yates MG

更新日期：2019-10-08 00:00:00

abstract：:The western North-Atlantic coast experienced major coastal floods in recent years. Coastal floods are primarily composed of tides and storm surges due to tropical (TCs) and extra-tropical cyclones (ETCs). We present a reanalysis from 1988 to 2015 of extreme sea levels that explicitly include TCs for the western North-...

journal_title：Scientific reports

authors： Muis S,Lin N,Verlaan M,Winsemius HC,Ward PJ,Aerts JCJH

更新日期：2019-03-04 00:00:00

abstract：:In the last forty years therapy outcomes for depression have remained the same with approximately 50% of patients responding to treatments. Advances are urgently required. We hypothesised that a recent treatment, metacognitive therapy (MCT), might be more effective, by targeting mental control processes that directly ...

journal_title：Scientific reports

authors： Callesen P,Reeves D,Heal C,Wells A

更新日期：2020-05-12 00:00:00

abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...

journal_title：Scientific reports

authors： Saw WY,Liu X,Khor CC,Takeuchi F,Katsuya T,Kimura R,Nabika T,Ohkubo T,Tabara Y,Yamamoto K,Yokota M,Japanese Genome Variation Consortium.,Teo YY,Kato N

更新日期：2015-12-09 00:00:00

abstract：:This study proposed a novel method to heal microcrack within Mg alloy tubes using high density eddy current pulse treatment (ECPT). Through electromagnetic induction inside a copper coil connected with a high density pulse power source supply, the high density (greater than 5 × 109 A/m2) and short duration eddy curren...

journal_title：Scientific reports

authors： Xu W,Yang C,Yu H,Jin X,Guo B,Shan D

更新日期：2018-04-16 00:00:00

abstract：:ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...

journal_title：Scientific reports

authors： Vautrin A,Manchon L,Garcel A,Campos N,Lapasset L,Laaref AM,Bruno R,Gislard M,Dubois E,Scherrer D,Ehrlich JH,Tazi J

更新日期：2019-01-28 00:00:00

abstract：:By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm(2)/Vs with an electron density of 9.3 × 10...

journal_title：Scientific reports

authors： Cheng J,Yang X,Sang L,Guo L,Zhang J,Wang J,He C,Zhang L,Wang M,Xu F,Tang N,Qin Z,Wang X,Shen B

更新日期：2016-03-10 00:00:00

abstract：:Several single-center studies have investigated whether narrow-band imaging (NBI) cystoscopy is more effective in detecting primary and recurrent non-muscle invasive bladder cancer (NMIBC) compared with white-light imaging (WLI) cystoscopy. In this study, we further evaluated the diagnostic value of NBI cystoscopy com...

journal_title：Scientific reports

authors： Ye Z,Hu J,Song X,Li F,Zhao X,Chen S,Wang X,He D,Fan J,Ye D,Xing J,Pan T,Wang D

更新日期：2015-06-05 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...

journal_title：Scientific reports

authors： Giel-Moloney M,Goncalvez AP,Catalan J,Lecouturier V,Girerd-Chambaz Y,Diaz F,Maldonado-Arocho F,Gomila RC,Bernard MC,Oomen R,Delagrave S,Burdin N,Kleanthous H,Jackson N,Heinrichs J,Pugachev KV

更新日期：2018-09-04 00:00:00

abstract：:Drug resistance is a major issue in the treatment of glioblastoma. Almost all glioblastomas are intrinsically resistant to chemotherapeutic temozolomide (TMZ) or develop resistance during treatment. The interaction networks of microRNAs (miRNAs) and mRNAs likely regulate most biological processes and can be employed t...

journal_title：Scientific reports

authors： Hiddingh L,Raktoe RS,Jeuken J,Hulleman E,Noske DP,Kaspers GJ,Vandertop WP,Wesseling P,Wurdinger T

更新日期：2014-06-11 00:00:00

abstract：:Rodents are important reservoir hosts of many important zoonotic viruses. The family Picornaviridae contains clinically important pathogens that infect humans and animals, and increasing numbers of rodent picornaviruses have recently been associated with zoonoses. We collected 574 pharyngeal and anal swab specimens fr...

journal_title：Scientific reports

authors： Du J,Lu L,Liu F,Su H,Dong J,Sun L,Zhu Y,Ren X,Yang F,Guo F,Liu Q,Wu Z,Jin Q

更新日期：2016-09-29 00:00:00

abstract：:We report on a combined photoluminescence imaging and atomic force microscopy study of single, isolated self-assembled InAs quantum dots. The motivation of this work is to determine an approach that allows to assess single quantum dots as candidates for quantum nanophotonic devices. By combining optical and scanning p...

journal_title：Scientific reports

authors： Sapienza L,Liu J,Song JD,Fält S,Wegscheider W,Badolato A,Srinivasan K

更新日期：2017-07-24 00:00:00

abstract：:The ability to observe chemical reactions at the molecular level convincingly demonstrates the physical and chemical phenomena occurring throughout a reaction mechanism. Videos obtained through in situ transmission electron microscopy (TEM) revealed the oxidation of catalytic soot under practical reaction conditions. ...

journal_title：Scientific reports

authors： Kamatani K,Higuchi K,Yamamoto Y,Arai S,Tanaka N,Ogura M

更新日期：2015-07-08 00:00:00

abstract：:Polarity-sensitive fluorescent probes are powerful chemical tools for studying biomolecular structures and activities both in vitro and in vivo. However, the lack of "off-on" polarity-sensing probes has limited the accurate monitoring of biological processes that involve an increase in local hydrophilicity. Here, we d...

journal_title：Scientific reports

authors： Zhu H,Fan J,Mu H,Zhu T,Zhang Z,Du J,Peng X

更新日期：2016-10-21 00:00:00

abstract：:The current anaesthesia information management system (AIMS) has limited capability for the acquisition of high-quality vital signs data. We have developed a Vital Recorder program to overcome the disadvantages of AIMS and to support research. Physiological data of surgical patients were collected from 10 operating ro...

journal_title：Scientific reports

authors： Lee HC,Jung CW

更新日期：2018-01-24 00:00:00

abstract：:Alveolar type II epithelial cells (ATII) are instrumental in early wound healing in response to lung injury, restoring epithelial integrity through spreading and migration. We previously reported in separate studies that focal adhesion kinase-1 (FAK) and the chemokine receptor CXCR4 promote epithelial repair mechanism...

journal_title：Scientific reports

authors： Ghosh MC,Makena PS,Kennedy J,Teng B,Luellen C,Sinclair SE,Waters CM

更新日期：2017-05-19 00:00:00

abstract：:Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer's disease. Chemical genetic screening of endothelial tube formation provides a robust approach for identifying signalling components that impact microvascular network morphology as well as endothelial cell biol...

journal_title：Scientific reports

authors： Sailem HZ,Al Haj Zen A

更新日期：2020-08-14 00:00:00

abstract：:S-resistin, a non-secretable resistin isoform, acts as an intracrine factor that regulates adipocyte maduration, inflammatory and insulin response in 3T3-L1 cells. However, its intracellular function in vivo is still unknown. In this study, we analyze the central role of s-resistin, decreasing its hypothalamic express...

journal_title：Scientific reports

authors： Rodríguez M,Pintado C,Moltó E,Gallardo N,Fernández-Martos CM,López V,Andrés A,Arribas C

更新日期：2018-03-02 00:00:00

abstract：:Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and postnatal (11 months old) pancreatic structure and function. Of thre...

journal_title：Scientific reports

authors： Ramaswamy S,Grace C,Mattei AA,Siemienowicz K,Brownlee W,MacCallum J,McNeilly AS,Duncan WC,Rae MT

更新日期：2016-06-06 00:00:00

abstract：:Existing understanding of molecular composition of sputum and its role in tuberculosis patients is variously limited to its diagnostic potential. We sought to identify infection induced sputum proteome alteration in active/non tuberculosis patients (A/NTB) and their role in altered lung patho-physiology. Out of the st...

journal_title：Scientific reports

authors： Bishwal SC,Das MK,Badireddy VK,Dabral D,Das A,Mahapatra AR,Sahu S,Malakar D,Singh II,Mazumdar H,Patgiri SJ,Deka T,Kapfo W,Liegise K,Kupa RU,Debnath S,Bhowmik R,Debnath R,Behera RK,Pillai MG,Deuri P,Nath R,Khal

更新日期：2019-01-31 00:00:00

abstract：:Previous studies have investigated the use of mesenchymal stem cells (MSCs) to treat damaged kidneys. However, the effect of adipose-derived MSCs (ASCs) on vascular calcification in chronic kidney disease (CKD) is still poorly understood. In the present study, we explored the potential of ASCs for the treatment of CKD...

journal_title：Scientific reports

authors： Yokote S,Katsuoka Y,Yamada A,Ohkido I,Yokoo T

更新日期：2017-10-25 00:00:00