Abstract:
:Several single-center studies have investigated whether narrow-band imaging (NBI) cystoscopy is more effective in detecting primary and recurrent non-muscle invasive bladder cancer (NMIBC) compared with white-light imaging (WLI) cystoscopy. In this study, we further evaluated the diagnostic value of NBI cystoscopy compared with WLI cystoscopy for primary NMIBC in a multi-center study. Suspected bladder cancer patients from 8 research centers received both NBI and WLI. Two experienced doctors in each center were responsible for the NBI and WLI assessments, respectively. The number of tumors and position of each tumor were recorded, and suspicious tissues were clamped and histologically examined. The sensitivity, specificity, and false-positive rate of NBI and WLI were evaluated. Of the 384 patients, 78 had a confirmed urothelial carcinoma (UC). The sensitivities of NBI and WLI were 97.70%, and 66.67%, respectively (P < 0.0001); the specificities were 50% and 25%, respectively; and the false positive rates were 50% and 75%, respectively. Based on 300 valid biopsy specimens, the NBI and WLI sensitivities were 98.80% and 75.45%, respectively (P < 0.0001). These results suggest that NBI has a high sensitivity and has superior early bladder tumor and carcinoma in situ (CIS) detection rates compared with WLI cystoscopy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ye Z,Hu J,Song X,Li F,Zhao X,Chen S,Wang X,He D,Fan J,Ye D,Xing J,Pan T,Wang Ddoi
10.1038/srep10905subject
Has Abstractpub_date
2015-06-05 00:00:00pages
10905issn
2045-2322pii
srep10905journal_volume
5pub_type
杂志文章,多中心研究,随机对照试验abstract::Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21923-8
更新日期:2018-02-27 00:00:00
abstract::The lignite biodegradation procedure to produce water-soluble humic materials (WSHM) with a Penicillium stain was established by previous studies in our laboratory. This study researched the effects of WSHM on the growth of Bradyrhizobium liaoningense CCBAU05525 and its nodulation on soybean. Results showed that WSHM ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10836
更新日期:2015-06-08 00:00:00
abstract::Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas data on brain-dead donors (DBD) are scarce. To assess the impact of end-ischemic HOPE i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45843-3
更新日期:2019-06-27 00:00:00
abstract::Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the population dynamics. While these sources are usually studied separately, we develop an agent-based framework that accounts for both factors while tracking every single cell of a growing population. Apart from the common intrinsic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35927-x
更新日期:2019-01-24 00:00:00
abstract::Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome At...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39812
更新日期:2017-01-03 00:00:00
abstract::Solid oxide fuel cells (SOFC) are the cleanest, most efficient, and cost-effective option for direct conversion to electricity of a wide variety of fuels. While significant progress has been made in anode materials with enhanced tolerance to coking and contaminant poisoning, cathodic polarization still contributes con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02426
更新日期:2013-01-01 00:00:00
abstract::Soil degradation due to erosion is a significant worldwide problem at different spatial (from pedon to watershed) and temporal scales. All stages and factors in the erosion process must be detected and evaluated to reduce this environmental issue and protect existing fertile soils and natural ecosystems. Laboratory st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76926-1
更新日期:2020-11-19 00:00:00
abstract::P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We charac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71753-w
更新日期:2020-09-24 00:00:00
abstract::We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the double-knockout (DKO) mice, as detected by immunofluorescence and immunoblots for urothelial proteins including uro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00317
更新日期:2012-01-01 00:00:00
abstract::Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of the bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications of the bacterial cell wall in the course of its biosynthesis, recycling, manifestation of virulence, inserti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22527-y
更新日期:2018-03-07 00:00:00
abstract::The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78700-9
更新日期:2020-12-10 00:00:00
abstract::Developmental changes in salamander skulls, before and after metamorphosis, affect the feeding capabilities of these animals. How changes in cranial morphology and tissue properties affect the function of the skull are key to decipher the early evolutionary history of the crown-group of salamanders. Here, 3D cranial b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10553-1
更新日期:2017-08-31 00:00:00
abstract::TiO2/graphene (TiO2-x/GR) composites, which are Ti(3+) self-doped TiO2 nanorods decorated on boron doped graphene sheets, were synthesized via a simple one-step hydrothermal method using low-cost NaBH4 as both a reducing agent and a boron dopant on graphene. The resulting TiO2 nanorods were about 200 nm in length with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05493
更新日期:2014-06-30 00:00:00
abstract::In a previous study, we proposed that age-related mitochondrial respiration defects observed in elderly subjects are partially due to age-associated downregulation of nuclear-encoded genes, including serine hydroxymethyltransferase 2 (SHMT2), which is involved in mitochondrial one-carbon (1C) metabolism. This assertio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52372-6
更新日期:2019-11-05 00:00:00
abstract::Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23984-1
更新日期:2018-04-04 00:00:00
abstract::The effects of biogeographical separation and parent material differences in soil bacterial structure and diversity in offshore islands remain poorly understood. In the current study, we used next-generation sequencing to characterize the differences in soil bacterial communities in five offshore subtropical granite i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41170-9
更新日期:2019-03-20 00:00:00
abstract::Globally, Aedes aegypti is one of the most dangerous mosquitoes that plays a crucial role as a vector for human diseases, such as yellow fever, dengue, and chikungunya. To identify (1) transcriptomic basis of midgut (2) key genes that are involved in the toxicity process by a comparative transcriptomic analysis betwee...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30741-x
更新日期:2018-08-23 00:00:00
abstract::Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30033-4
更新日期:2018-08-02 00:00:00
abstract:ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14708-y
更新日期:2017-10-27 00:00:00
abstract::Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the tw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05907-8
更新日期:2017-07-17 00:00:00
abstract::Herbs may contain pesticide residues which are an important discriminator of food security and food quality. The challenge of the research was to assess the fate of the herbicide clethodim (CLE) and the insecticide spirotetramat (SPI) applied in herbs (BBCH 11-21) during herb growth and processing under controlled gre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58130-3
更新日期:2020-01-28 00:00:00
abstract::The complete genome of a novel coronavirus was sequenced directly from the cloacal swab of a Canada goose that perished in a die-off of Canada and Snow geese in Cambridge Bay, Nunavut, Canada. Comparative genomics and phylogenetic analysis indicate it is a new species of Gammacoronavirus, as it falls below the thresho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42355-y
更新日期:2019-04-11 00:00:00
abstract::TET aminopeptidases are dodecameric particles shared in the three life domains involved in various biological processes, from carbon source provider in archaea to eye-pressure regulation in humans. Each subunit contains a dinuclear metal site (M1 and M2) responsible for the enzyme catalytic activity. However, the role...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20876
更新日期:2016-02-08 00:00:00
abstract::Up to now, full tunability of waveforms was possible only in electronics, up to radio-frequencies. Here we propose a new concept of producing few-cycle terahertz (THz) pulses with widely tunable waveforms. It is based on control of the phase delay between different parts of the THz wavefront using linear diffractive o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43852-w
更新日期:2019-05-15 00:00:00
abstract::A number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41161-w
更新日期:2019-03-14 00:00:00
abstract::Rice stripe virus-infected females of the small brown planthopper (SBPH, Laodelphax striatellus) usually lay fewer eggs with a longer hatch period, low hatchability, malformation and retarded or defective development compared with healthy females. To explore the molecular mechanism of those phenomena, we analyzed the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27216
更新日期:2016-06-09 00:00:00
abstract::Roselle-Hibiscus sabdariffa L. leaves at different stages of growth, calyces and seeds were analyzed for nutritional and anti-nutritional factors. All the treatments contained a good but varied proportion of carbohydrate in a range of 26.93-54.13%, crude protein from 5.7 to 27.06%, crude fat 1.16-13.09%, crude fibre 1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80433-8
更新日期:2021-01-13 00:00:00
abstract::With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23111-0
更新日期:2018-03-23 00:00:00
abstract::G-protein-coupled receptors (GPCRs) are important drug targets with diverse therapeutic applications. However, there are still more than a hundred orphan GPCRs, whose protein functions and biochemical features remain unidentified. Gpr176 encodes a class-A orphan GPCR that has a role in circadian clock regulation in mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61370-y
更新日期:2020-03-10 00:00:00
abstract::Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 mediates viral entry i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15577
更新日期:2015-10-20 00:00:00