Abstract：
:We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the double-knockout (DKO) mice, as detected by immunofluorescence and immunoblots for urothelial proteins including uroplakin IIIa. The AUAb-positive DKO mice showed degeneration of urothelial plaque and umbrella cells, along with infiltration of inflammatory cells in the suburothelial layer. TNFα and IL-1β were upregulated in the bladder and the urine of AUAb-positive DKO mice. Voiding behavior of mice was analyzed by the Voided Stain on Paper method. 10-week-old and older AUAb-positive DKO mice voided significantly less urine per void than did wild type (WT) mice. Furthermore, administration of the AUAb-containing serum to WT mice significantly reduced their urine volume per void. In summary, this report presents a novel comprehensive mouse model of autoimmune cystitis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sugino Y,Nishikawa N,Yoshimura K,Kuno S,Hayashi Y,Yoshimura N,Okazaki T,Kanematsu A,Ogawa Odoi
10.1038/srep00317subject
Has Abstractpub_date
2012-01-01 00:00:00pages
317issn
2045-2322journal_volume
2pub_type
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