Abstract：
:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide composite would curl into capsules under a strongly acidic saturated solution of heavy metallic salt solution at low temperature. Secondly, L-amino acids exhibited higher reactivity than D-amino acids on graphene oxides to form peptides, and the formed peptides in the influence of graphene would be transformed into a secondary structure, promoting the formation of left-handed proteins. Lastly, monolayer nanoporous graphene, prepared by unfocused (84)Kr(25+), has a high selectivity for permeation of the monovalent metal ions ( Rb(+) > K(+) > Cs(+) > Na(+) > Li(+), based on permeation concentration), but does not allow Cl(-) go through. It is similar to K(+) channels, which would cause an influx of K(+) into capsule of graphene with the increase of pH in the primitive ocean, creating a suitable inner condition for the origin of life. Therefore, we built a model cell of graphene, which would provide a route for reproducing the origin of life.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen Adoi
10.1038/srep10258subject
Has Abstractpub_date
2015-05-19 00:00:00pages
10258issn
2045-2322pii
srep10258journal_volume
5pub_type
杂志文章abstract：:Therapies targeting somatic bystander genetic events represent a new avenue for cancer treatment. We recently identified a subset of colorectal cancer (CRC) patients who are heterozygous for a wild-type and a low activity allele (NAT2*6) but lack the wild-type allele in their tumors due to loss of heterozygosity (LOH)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80288-z
更新日期：2020-12-31 00:00:00
abstract：:Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69303-5
更新日期：2020-07-28 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-020-70805-5
更新日期：2020-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00031
更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-018-27753-y
更新日期：2018-06-22 00:00:00
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pub_type： 杂志文章
doi：10.1038/srep36950
更新日期：2016-11-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36488-9
更新日期：2019-01-23 00:00:00
abstract：:Homocysteine (Hcy) has been shown to have a neurotoxic effect on ischemic brain cells; however, the underlying mechanisms remain incompletely understood. Here, we examined whether Hcy treatment influences mitochondria injury, oxidative stress, and mitochondrial STAT3 (mitoStat3) expression in rat ischemic brain. Our r...
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pub_type： 杂志文章
doi：10.1038/s41598-017-07112-z
更新日期：2017-07-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37163
更新日期：2016-11-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17898
更新日期：2015-12-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15805
更新日期：2015-10-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48195-0
更新日期：2019-08-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24538-1
更新日期：2018-04-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42854-y
更新日期：2019-04-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27143-4
更新日期：2018-06-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28137-y
更新日期：2018-06-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12785-7
更新日期：2017-10-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51983-3
更新日期：2019-10-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36232-3
更新日期：2018-12-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36914-y
更新日期：2019-01-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09320
更新日期：2015-03-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27183-w
更新日期：2018-06-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30331-x
更新日期：2018-08-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34703
更新日期：2016-10-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64872-x
更新日期：2020-05-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01160
更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58826-6
更新日期：2020-02-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05000-0
更新日期：2017-07-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41786
更新日期：2017-02-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35927-x
更新日期：2019-01-24 00:00:00
