Abstract：
:Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here, using BALB/c mice intravenously infected with DENV-2 strain 66985, we demonstrated that the virus is capable of invading and damaging the host's central nervous system (CNS). Brain and cerebellum of infected animals revealed histological alterations such as the presence of inflammatory infiltrates, thickening of pia matter and disorganization of white matter. Additionally, it was also seen that infection lead to altered morphology of neuroglial cells and apoptotic cell death. Such observations highlighted possible alterations that DENV may promote in the host's CNS during a natural infection, hence, helping us to better understand the neuropathological component of the disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Salomão NG,Rabelo K,Póvoa TF,Alves AMB,da Costa SM,Gonçalves AJS,Amorim JF,Azevedo AS,Nunes PCG,Basílio-de-Oliveira CA,Basílio-de-Oliveira RP,Geraldo LHM,Fonseca CG,Lima FRS,Mohana-Borges R,Silva EM,Dos Santos FB,Oliveidoi
10.1038/s41598-018-28137-ysubject
Has Abstractpub_date
2018-06-27 00:00:00pages
9754issue
1issn
2045-2322pii
10.1038/s41598-018-28137-yjournal_volume
8pub_type
杂志文章abstract：:A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23698
更新日期：2016-03-24 00:00:00
abstract：:FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14124-2
更新日期：2017-10-23 00:00:00
abstract：:Most dogs worldwide are free-ranging animals that form relationships mainly with conspecifics, yet research has focused mainly on the dog-human bond, leading to the hypothesis that dogs evolved specific abilities to form a unique relationship with humans. Although widespread, this hypothesis has not, as yet, been test...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40164-x
更新日期：2019-03-05 00:00:00
abstract：:Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). The present study investigated the participation of the Notch receptor, NOTCH2, in the Jagged1-induced osteogenic differentiation in hPDLs. NOTCH2 and NOTCH4 mRNA expression levels increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70277-7
更新日期：2020-08-07 00:00:00
abstract：:The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29600
更新日期：2016-07-12 00:00:00
abstract：:CD26 displays variable levels between effector (TH17 ≫ TH1 > TH2 > Treg) and naïve/memory (memory > naïve) CD4+ T lymphocytes. Besides, IL-6/IL-6R is associated with TH17-differentiation and asthma severity. Allergic/atopic asthma (AA) is dominated by TH2 responses, while TH17 immunity might either modulate the TH2-de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43622-8
更新日期：2019-05-17 00:00:00
abstract：:The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15218-7
更新日期：2017-11-13 00:00:00
abstract：:Infestation of phosphine (PH3) resistant insects threatens global grain reserves. PH3 fumigation controls rice weevil (Sitophilus oryzae) but not highly resistant insect pests. Here, we investigated naturally occurring strains of S. oryzae that were moderately resistant (MR), strongly resistant (SR), or susceptible (w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50972-w
更新日期：2019-10-10 00:00:00
abstract：:Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09365-0
更新日期：2017-08-18 00:00:00
abstract：:We investigated the relationship between aqueous cytokine levels, changes in ocular blood flow, and morphological and functional improvements after intravitreal ranibizumab injection (IRI) in treatment-naïve eyes with center-involving diabetic macular edema (DME). Thirty-three eligible patients with DME (33 eyes) were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78792-3
更新日期：2020-12-10 00:00:00
abstract：:Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39641-0
更新日期：2019-02-25 00:00:00
abstract：:Collagen, the dominating material in the extracellular matrix, provides the strength, elasticity and mechanical stability to the organisms. The mechanical property of collagen is mainly dominated by its surrounding environments. However, the variation and origin of the mechanics of collagen fibril under different conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46042
更新日期：2017-04-05 00:00:00
abstract：:Oral squamous cell carcinoma (OSCC) is a common human malignancy with a high incidence rate and poor prognosis. Although astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in carcinogenesis and tumour progression, the impact of AEG-1 on the development and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15805-8
更新日期：2017-11-13 00:00:00
abstract：:Functional DNA sub-sequences and genome elements are spatially clustered through the genome just as keywords in literary texts. Therefore, some of the methods for ranking words in texts can also be used to compare different DNA sub-sequences. In analogy with the literary texts, here we claim that the distribution of d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41543
更新日期：2017-01-27 00:00:00
abstract：:Languages may differ in terms of the functional units of word-form encoding used in spoken word production. It is widely accepted that segments are the primary units used in Indo-European languages. However, it is controversial what the functional units (syllables or segments) in Chinese spoken word production are. In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48033-3
更新日期：2019-08-13 00:00:00
abstract：:Thymol, as a dietary monoterpene, is a phenol derivative of cymene, which is the major component of the essential oil of Trachyspermum ammi (L.). It shows multiple biological activities: antifungal, antibacterial, antivirus and anti-inflammatory. T. ammi, commonly known as ajowan, belongs to Apiaceae and is an importa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31618-9
更新日期：2018-09-07 00:00:00
abstract：:Almost half of the groundwater in the Pearl River Delta (PRD) contains salt water originally derived from paleo-seawater due to the Holocene transgression, which then generates intense physicochemical gradients in the mixing zone between freshwater and saltwater. Although some studies have been conducted on the hydrol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35350-2
更新日期：2018-11-23 00:00:00
abstract：:The incidence and mortality of primary liver cancer are very high and resection of tumor is the most crucial treatment for it. We aimed to assess the efficacy and safety of combined use of transversus abdominis plane (TAP) block and laryngeal mask airway (LMA) during implementing Enhanced Recovery After Surgery (ERAS)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71477-x
更新日期：2020-09-10 00:00:00
abstract：:Clustered regularly interspaced short palindromic repeats (CRISPR) in conjunction with CRISPR-associated proteins (Cas) can be employed to introduce double stand breaks into mammalian genomes at user-defined loci. The endonuclease activity of the Cas complex can be targeted to a specific genomic region using a single ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14987
更新日期：2015-10-08 00:00:00
abstract：:The Law of the Minimum is often implemented using t-norm or fuzzy intersection. We propose the use of t-conorm or fuzzy union for climate suitability assessment of a grass species using annual ryegrass (Lolium multiflorum Lam.) as an example and evaluate the performance for alfalfa (Medicago sativa L.) and sorghum (So...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28291-3
更新日期：2018-07-05 00:00:00
abstract：:The Field Effect sensors are broadly used for detecting various target analytes in chemical and biological solutions. We report the conditions under which the pH sensitivity of an Ion Sensitive Field Effect transistor (ISFET) sensor can be significantly enhanced. Our theory and simulations show that by using pH buffer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41305
更新日期：2017-02-02 00:00:00
abstract：:While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis. The results of molecular dynamic studies supported by the strong hydrogen-bonding equilibria of the participating atoms, radical stabilization...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67655-6
更新日期：2020-07-01 00:00:00
abstract：:This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabol...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/s41598-018-33843-8
更新日期：2018-10-31 00:00:00
abstract：:Trimethylation on H3K27 mediated by Polycomb Repressive Complex 2 (PRC2) is required to control gene repression programs involved in development, regulation of tissue homeostasis or maintenance and lineage specification of stem cells. In Drosophila, the PRC2 catalytic subunit is the single protein E(z), while in mamma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40738-9
更新日期：2019-03-13 00:00:00
abstract：:Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in Asia and its spread to Europe and North America has caused great concern for human health. Although the H5N8 virus has been only moderately pathogenic to mammalian hosts, virulence can still increase. We evaluated the pathogenic potential of several...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40667
更新日期：2017-01-17 00:00:00
abstract：:Crops have different strategies to acquire poorly-available soil phosphorus (P) which are dependent on their architectural, morphological, and physiological root traits, but their capacity to enhance P acquisition varies with the type of fertilizer applied. The objective of this study was to examine how P-acquisition ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51204-x
更新日期：2019-10-16 00:00:00
abstract：:Recently, development of Adeno-associated virus (AAV) vectors has been focusing on expanding the genetic diversity of vectors from existing sequences via directed evolution or epitope remapping. Apart from intelligent design, AAV isolation from natural sources remains an important source of new AAVs with unique biolog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06644
更新日期：2014-10-22 00:00:00
abstract：:Enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) with different physicochemical properties were developed to enhance activity against intracellular Salmonella. Their cellular uptake, intracellular elimination and antibacterial activity were studied in RAW 264.7 cells. During the experimental period...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41104
更新日期：2017-01-23 00:00:00
abstract：:Epidemiological studies using saliva have revealed relationships between the oral microbiome and many oral and systemic diseases. However, when collecting from a large number of participants such as a large-scale cohort study, the time it takes to collect saliva can be a problem. Mouth-rinsed water, which is water tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52445-6
更新日期：2019-11-06 00:00:00
abstract：:Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18573
更新日期：2016-01-14 00:00:00
