Abstract:
:This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mallorquí-Bagué N,Lozano-Madrid M,Toledo E,Corella D,Salas-Salvadó J,Cuenca-Royo A,Vioque J,Romaguera D,Martínez JA,Wärnberg J,López-Miranda J,Estruch R,Bueno-Cavanillas A,Alonso-Gómez Á,Tur JA,Tinahones FJ,Serra-Majem Ldoi
10.1038/s41598-018-33843-8subject
Has Abstractpub_date
2018-10-31 00:00:00pages
16128issue
1issn
2045-2322pii
10.1038/s41598-018-33843-8journal_volume
8pub_type
杂志文章,多中心研究,随机对照试验abstract::Silver nanoparticles (AgNPs) have been extensively used and are considered as an emerging contaminant in the ocean. The environmental contamination of AgNPs is expected to increase greatly over time, and cetaceans, as the top ocean predators, will suffer the negative impacts of AgNPs. In the present study, we investig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23737-0
更新日期:2018-04-04 00:00:00
abstract::Land use, habitat, and forage quality have emerged as critical factors influencing the health, productivity, and survival of honey bee colonies. However, characterization of the mechanistic relationship between differential land-use conditions and ultimate outcomes for honey bee colonies has been elusive. We assessed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52485-y
更新日期:2019-11-07 00:00:00
abstract::The cumulative effects of hepatic injury due to hepatitis B virus (HBV) infections and aflatoxin-B1 (AFB1) exposure are the major risk factors of HCC. Understanding early metabolic changes involving these risk factors in an animal model closely resembling human hepatocellular carcinoma (HCC) is critical for biomarker ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20299
更新日期:2016-02-02 00:00:00
abstract::Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32657
更新日期:2016-09-07 00:00:00
abstract::In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35549
更新日期:2016-10-17 00:00:00
abstract::Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intak...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24238
更新日期:2016-04-07 00:00:00
abstract::Glycoprotein nonmetastatic melanoma protein B (GPNMB) plays important roles in various types of cancer and amyotrophic lateral sclerosis (ALS). The details of GPNMB function and its interacting protein have not been clarified. Therefore, to identify GPNMB binding partners on the cell membrane, we used membrane protein...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23241
更新日期:2016-03-18 00:00:00
abstract::Most people with diabetes suffer some deterioration of the feet. Diabetic foot syndrome causes ulceration in about 15% of cases and such deterioration leads to amputation in about 2.5% of diabetic patients, diminishing their quality of life and generating extraordinary costs for patients and public health systems. Cur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42124
更新日期:2017-02-06 00:00:00
abstract::The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05525
更新日期:2014-07-02 00:00:00
abstract::Protein kinase B (PKB) also known as Akt is involved in many signal transduction pathways. As alterations of the PKB pathway are found in a number of human malignancies, PKB is considered an important drug target for cancer therapy. However, production of sufficient amounts of active PKB for biochemical and structural...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06016
更新日期:2014-08-15 00:00:00
abstract::The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental procedure for Kd determination using a quantitative FRET method. Here we report a new development of Kd de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35535-9
更新日期:2019-02-14 00:00:00
abstract::The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtaine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41042-2
更新日期:2019-03-12 00:00:00
abstract::The full length human histone 3 lysine 4 demethylase KDM5B (PLU-1/Jarid1B) has been studied using Hydrogen/Deuterium exchange mass spectrometry, homology modelling, sequence analysis, small angle X-ray scattering and electron microscopy. This first structure on an intact multi-domain Jumonji histone demethylase reveal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40573-y
更新日期:2019-03-11 00:00:00
abstract::The LiBH4/CaH2 composite are firstly studied as Concentrating Solar Power Thermal Storage Material. The LiBH4/CaH2 composite according to the stoichiometric ratio are synthesized by high-energy ball milling method. The kinetics, thermodynamics and cycling stability of LiBH4/CaH2 composite are investigated by XRD (X-ra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41754
更新日期:2017-01-31 00:00:00
abstract::We introduce a simple method to characterize the topological charge associated with the orbital angular momentum of a m-order elliptic light beam. This method consists in the observation of the far field pattern of the beam carrying orbital angular momentum, diffracted from a triangular aperture. We show numerically a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24928-5
更新日期:2018-04-23 00:00:00
abstract::Viral nervous necrosis (VNN) certainly represents the biggest challenge for the sustainability and the development of aquaculture. A large number of economically relevant fish species have proven to be susceptible to the disease. Conversely, gilthead sea bream has generally been considered resistant to VNN, although i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46755
更新日期:2017-05-02 00:00:00
abstract::Hedgehog (Hh) signaling plays a broad role in the development of many organs including bone and teeth. It is noted that sustained Hh activity in osteoblasts negatively regulates postnatal development in mice. However, it remains unknown whether Hh signaling contributes to cementum formation. In this study, to define t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64188-w
更新日期:2020-04-29 00:00:00
abstract::We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22025
更新日期:2016-02-25 00:00:00
abstract::Species are chronically exposed to ionizing radiation, a natural phenomenon which can be enhanced by human activities. The induced toxicity mechanisms still remain unclear and seem depending on the mode of exposure, i.e. acute and chronic. To better understand these phenomena, studies need to be conducted both at the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29033-1
更新日期:2018-07-27 00:00:00
abstract::The ability to obtain three-dimensional (3-D) information about morphologies of nanostructures elucidates many interesting properties of materials in both physical and biological sciences. Here we demonstrate a novel method in scanning transmission electron microscopy (STEM) that gives a fast and reliable assessment o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07537-6
更新日期:2017-09-06 00:00:00
abstract::Challenges in social communication and interaction are core features of autism spectrum disorder (ASD) for which social skills group training (SSGT) is a commonly used intervention. SSGT has shown modest and heterogeneous effects. One of the major genetic risk factors in ASD is rare copy number variation (CNV). Howeve...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-46396-1
更新日期:2019-07-08 00:00:00
abstract::Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13930-y
更新日期:2017-10-25 00:00:00
abstract::Phase estimation represents a crucial challenge in many fields of Physics, ranging from Quantum Metrology to Quantum Information Processing. This task is usually pursued by means of interferometric schemes, in which the choice of the input states and of the detection apparatus is aimed at minimizing the uncertainty in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26025
更新日期:2016-05-18 00:00:00
abstract::Space radiation brings uneven damages to cells. The detection of the distribution of cell damage plays a very important role in radiation medicine and the related research. In this paper, a new hand-held microfluidic flow cytometer was developed to evaluate the degree of radiation damage of cells. The device we propos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23165
更新日期:2016-03-17 00:00:00
abstract::Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46166
更新日期:2017-04-11 00:00:00
abstract::Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the potential of damnacanthal as a natural antitumor compound. The direct effect of damnacanthal on c-Met was tested by in vitro activity assays. Additio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08021
更新日期:2015-01-26 00:00:00
abstract::Sealed-bid auction is an important tool in modern economic especially concerned with networks. However, the bidders still lack the privacy protection in previously proposed sealed-bid auction schemes. In this paper, we focus on how to further protect the privacy of the bidders, especially the non-winning bidders. We f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44030-8
更新日期:2019-05-20 00:00:00
abstract::This work presents a method of grouping the electron spinors and the phonon modes of metal oxide crystals such as vanadium dioxide into an SU(2) gauge theory. The gauge "charge" is the electron spin, which is assumed to couple to the transverse acoustic phonons on the basis of spin ordering phenomena in [Formula: see ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68958-4
更新日期:2020-07-27 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58227-9
更新日期:2020-01-24 00:00:00
abstract::The sulfur-selenium doped carbon quantum dots (S,Se-CQDs) were synthesized by one-step through hydrothermal method in this study, which have high fluorescence quantum yield (43%) and advanced ability to scavenge reactive oxygen species (ROS). They were characterized by transmission electron microscope (TEM), nuclear m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55996-w
更新日期:2019-12-23 00:00:00