Abstract:
:Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species have very high mean blubber PCB concentrations likely to cause population declines and suppress population recovery. In a large pan-European meta-analysis of stranded (n = 929) or biopsied (n = 152) cetaceans, three out of four species:- striped dolphins (SDs), bottlenose dolphins (BNDs) and killer whales (KWs) had mean PCB levels that markedly exceeded all known marine mammal PCB toxicity thresholds. Some locations (e.g. western Mediterranean Sea, south-west Iberian Peninsula) are global PCB "hotspots" for marine mammals. Blubber PCB concentrations initially declined following a mid-1980s EU ban, but have since stabilised in UK harbour porpoises and SDs in the western Mediterranean Sea. Some small or declining populations of BNDs and KWs in the NE Atlantic were associated with low recruitment, consistent with PCB-induced reproductive toxicity. Despite regulations and mitigation measures to reduce PCB pollution, their biomagnification in marine food webs continues to cause severe impacts among cetacean top predators in European seas.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jepson PD,Deaville R,Barber JL,Aguilar À,Borrell A,Murphy S,Barry J,Brownlow A,Barnett J,Berrow S,Cunningham AA,Davison NJ,Ten Doeschate M,Esteban R,Ferreira M,Foote AD,Genov T,Giménez J,Loveridge J,Llavona Á,Martdoi
10.1038/srep18573subject
Has Abstractpub_date
2016-01-14 00:00:00pages
18573issn
2045-2322pii
srep18573journal_volume
6pub_type
杂志文章abstract::Superresolution microscopy offers the advantage of imaging biological structures within cells at the nano-scale. Here we apply two superresolution microscopy techniques, specifically 3D structured illumination microscopy (3D-SIM) and direct stochastic optical reconstruction microscopy (dSTORM), a type of single molecu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38851-w
更新日期:2019-02-21 00:00:00
abstract::During interpersonal interactions, people perform actions with different forms of vitality, communicating their positive or negative attitude toward others. For example, a handshake can be "soft" or "vigorous", a caress can be 'kind' or 'rushed'. While previous studies have shown that the dorso-central insula is a key...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73728-3
更新日期:2020-10-09 00:00:00
abstract::Novel-morphological Fe3O4 nanosheets with magnetochromatic property have been prepared by a modified solvothermal method. Such nanosheets could form one-dimension photonic crystal under an external magnetic field. The Fe3O4 nanosheets suspension could strongly diffract visible light and display varied colors with chan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09320
更新日期:2015-03-23 00:00:00
abstract::A novel type of sub-lattice of the Jahn-Teller (JT) centers was arranged in Ti-doped barium hexaferrite BaFe12O19. In the un-doped crystal all iron ions, sitting in five different crystallographic positions, are Fe3+ in the high-spin configuration (S = 5/2) and have a non-degenerate ground state. We show that the elec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63915-7
更新日期:2020-04-27 00:00:00
abstract::The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.76, SD = 0.59) with s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37753-7
更新日期:2019-02-04 00:00:00
abstract::Recently, electromagnetic (EM) waves carrying orbital angular momentum (OAM) has received considerable attention in increasingly many different realms, such as communication systems, super-resolution imaging, optical communications and quantum state manipulation. In this paper, two different kinds of two dimensional (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64278-9
更新日期:2020-04-30 00:00:00
abstract::Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26161
更新日期:2016-05-17 00:00:00
abstract::Although the association between visual acuity (VA) and vision-related quality of life (VRQoL) has been well reported in patients with type 2 diabetes mellitus (T2DM), little is known about how unilateral and bilateral VA affects daily performance in such patients. For this cross-sectional study, patients were recruit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79483-9
更新日期:2021-01-11 00:00:00
abstract::The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and spec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25199-w
更新日期:2018-05-17 00:00:00
abstract::Diabetes mellitus (DM) exhibits a higher sensitivity to myocardial ischemia/reperfusion (I/R) injury and may compromise the effectiveness of cardioprotective interventions, including ischemic preconditioning. We previously found that liver ischemic preconditioning (RLIPC) could limit infarct size post I/R in non-diabe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81422-1
更新日期:2021-01-21 00:00:00
abstract::As a class, 'BET' inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to inhibit gene transcription. As such, BET inhibitors may be useful ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46516-x
更新日期:2019-07-16 00:00:00
abstract::A junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux. It breaks the time-reversal symmetry at the boundary of the sample. The persistent current is dete...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07492-2
更新日期:2017-08-02 00:00:00
abstract::Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70259-9
更新日期:2020-08-07 00:00:00
abstract::This work demonstrates an anisotropic increase in resistivity with decreasing width in single crystal tungsten (W) nanowires having a height of 21 nm. Nanowire-widths were in the range of 15-451 nm, with the anisotropy observed for widths below 50 nm. The longitudinal directions of the nanowires coincided with the <10...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02591
更新日期:2013-01-01 00:00:00
abstract::Development of new antimicrobial agents is required against the causative agent for listeriosis, Listeria monocytogenes, as the number of drug resistant strains continues to increase. A promising target is the β-ketoacyl-acyl carrier protein synthase FabF, which participates in the catalysis of fatty acid synthesis an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39277
更新日期:2017-01-03 00:00:00
abstract::Although graphene is a typical two dimensional materials, it has converted to multi-dimensional materials with many unique properties. As an example, the one dimensional graphene fiber is fabricated by utilizing ionic liquid as coagulation and functional diamines as cross-linkers to connect graphene oxide layers. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29534
更新日期:2016-07-08 00:00:00
abstract::The Great Amazon Reef (GARS) is an extensive mesophotic reef ecosystem between Brazil and the Caribbean. Despite being considered as one of the most important mesophotic reef ecosystems of the South Atlantic, recent criticism on the existence of a living reef in the Amazon River mouth was raised by some scientists and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50245-6
更新日期:2019-09-23 00:00:00
abstract::Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72494-6
更新日期:2020-09-28 00:00:00
abstract::Body mass index (BMI) is associated with increased future risk of inflammatory bowel disease(IBD) particularly Crohn's disease(CD), where associations with high and low BMI have been observed. Most studies are based on adult women. We aimed to explore the impact of BMI in men entering adult life on their long-term ris...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42642-8
更新日期:2019-04-23 00:00:00
abstract::Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77117-8
更新日期:2020-11-20 00:00:00
abstract::In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10469
更新日期:2015-05-28 00:00:00
abstract::Loss of cardiomyocyte proliferative capacity after birth is a major obstacle for therapeutic heart regeneration in adult mammals. We and others have recently shown the importance of hypoxic in utero environments for active foetal cardiomyocyte proliferation. Here, we report the unexpected expression of novex-3, the sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30886-9
更新日期:2018-08-17 00:00:00
abstract::Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58430-8
更新日期:2020-01-30 00:00:00
abstract::Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mitomycin-C or olaparib and (iii) reduced RAD51 loading at IR-induced DSBs upon PTEN knockdown. No association w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22289-7
更新日期:2018-03-02 00:00:00
abstract::We have designed a fully automated optical microscope running at high-speed and achieving a very high spatial resolution. In order to overcome the resolution limit of optical microscopes, it exploits the localized surface plasmon resonance phenomenon. The customized setup using a polarization analyzer, based on liquid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75883-z
更新日期:2020-11-02 00:00:00
abstract::Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21896
更新日期:2016-02-23 00:00:00
abstract::Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, stati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13373
更新日期:2015-08-24 00:00:00
abstract::We present a new model of ESR1 network regulation based on analysis of Doxorubicin, Estradiol, and TNFα combination treatment in MCF-7. We used Doxorubicin as a therapeutic agent, TNFα as marker and mediator of an inflammatory microenvironment and 17β-Estradiol (E2) as an agonist of Estrogen Receptors, known predispos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51349-9
更新日期:2019-10-23 00:00:00
abstract::Identification of hot spots, a small portion of protein-protein interface residues that contribute the majority of the binding free energy, can provide crucial information for understanding the function of proteins and studying their interactions. Based on our previous method (PredHS), we propose a new computational a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32511-1
更新日期:2018-09-24 00:00:00
abstract::Water-saving and drought-resistantce rice (WDR) breeding practices have greatly increased grain yield and drought resistance. To study the genetic basis of adaptation to drought, transcriptome sequences from the WDR maintainer line HuHan2B and the recurrent parent HanFengB were analyzed for alternative splicing (AS) c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12020-3
更新日期:2017-09-15 00:00:00