Abstract：
:Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance over conventional biomarkers were investigated. The T-AN and H-AN assays had high reproducibility, good linearity, and sufficient sensitivity to detect trace amounts of adiponectin in the urine. Urine samples after gel filtration were analyzed for the presence of different molecular isoforms. Low molecular weight (LMW) forms and monomers were the major components (93%) of adiponectin in the urine from a diabetic patient with normoalbuminuria. Urine from a microalbuminuria patient contained both high molecular weight (HMW) (11%) and middle molecular weight (MMW) (28%) adiponectin, although the LMW level was still high (52%). The amount of HMW (32%) and MMW (42%) were more abundant than that of LMW (24%) in a diabetic patient with macroalbuminuria. T-AN (r = - 0.43) and H-AN (r = - 0.38) levels showed higher correlation with estimated GFR (eGFR) than UAER (r = - 0.23). Urinary levels of both T-AN and H-AN negatively correlated with renal function in diabetic patients and they may serve as new biomarkers for diabetic kidney disease.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Watanabe T,Fujimoto Y,Morimoto A,Nishiyama M,Kawai A,Okada S,Aiba M,Kawano T,Kawahigashi M,Ishizu M,Mori H,Matsuhisa M,Hata A,Funaki M,Hashida Sdoi
10.1038/s41598-020-72494-6subject
Has Abstractpub_date
2020-09-28 00:00:00pages
15869issue
1issn
2045-2322pii
10.1038/s41598-020-72494-6journal_volume
10pub_type
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