Role of PARP1-mediated autophagy in EGFR-TKI resistance in non-small cell lung cancer.

abstract：:Accumulating evidences have suggested the potential association between Int7G24A (rs334354) polymorphism and cancer risk. However, results from epidemiological studies are controversial. We thus conducted this meta-analysis to clarify the association. Relevant studies were identified on electronic databases according ...

journal_title：Scientific reports

authors： Wu W,Tong Y,Wei X,Zhao Q,Pan X,Yu G,Lu Q

更新日期：2015-06-15 00:00:00

abstract：:In 2010, a pathogenic flavivirus termed duck Tembusu virus (DTMUV) caused widespread outbreak of egg-drop syndrome in domesticated ducks in China. Although the glycoprotein E of DTMUV is an important structural component of the virus, the B-cell epitopes of this protein remains uncharacterized. Using phage display and...

journal_title：Scientific reports

authors： Li C,Bai X,Meng R,Shaozhou W,Zhang Q,Hua R,Liu JH,Liu M,Zhang Y

更新日期：2016-11-08 00:00:00

abstract：:To characterize the molecular mechanisms underlying life-stage transitions in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhibitor of morphological development from microbial culture extracts prepared mostly from actinomycetes from soil in Japan. Of the more tha...

journal_title：Scientific reports

authors： Tani S,Nishio N,Kai K,Hagiwara D,Ogata Y,Tojo M,Sumitani JI,Judelson HS,Kawaguchi T

更新日期：2020-12-18 00:00:00

abstract：:Aditoprim (ADP) is a newly developed antibacterial agent in veterinary medicine. The metabolism and disposition of ADP in swine, broilers, carp and rats were investigated by using a radio tracer method combined with a radioactivity detector and a liquid chromatography/ion trap/time-of-flight mass spectrometry. After a...

journal_title：Scientific reports

authors： Wang L,Huang L,Pan Y,Kuča K,Klímová B,Wu Q,Xie S,Ahmad I,Chen D,Tao Y,Wan D,Liu Z,Yuan Z

更新日期：2016-02-03 00:00:00

abstract：:Impedance, or oscillometry, measurements of the respiratory system can generate information about the function of the respiratory system not possible with traditional spirometry. There are currently several instruments on the market using different perturbations. We have compared a new respiratory oscillometry instrum...

journal_title：Scientific reports

authors： Lundblad LKA,Miletic R,Piitulainen E,Wollmer P

更新日期：2019-08-12 00:00:00

abstract：:Meaningful, reliable and valid mRNA expression analyses by real-time quantitative PCR (RT-qPCR) can only be achieved, if suitable reference genes are chosen for normalization and if appropriate RT-qPCR quality standards are met. Human periodontal ligament (hPDL) fibroblasts play a major mediating role in orthodontic t...

journal_title：Scientific reports

authors： Kirschneck C,Batschkus S,Proff P,Köstler J,Spanier G,Schröder A

更新日期：2017-11-07 00:00:00

abstract：:Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

journal_title：Scientific reports

authors： Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

更新日期：2012-01-01 00:00:00

abstract：:Insecticides are the main method of controlling lepidopteran pests of eucalyptus plantations and those selective to natural enemies, such as the endoparasitoid Palmistichus elaeisis Delvare et LaSalle (Hymenoptera: Eulophidae), are preferable. The objective of this study was to evaluate the selectivity and effects on ...

journal_title：Scientific reports

authors： Pereira Costa ES,Soares MA,Caldeira ZV,Von Dos Santos Veloso R,da Silva LA,da Silva DJH,de Lima Santos IC,de Castro E Castro BM,Zanuncio JC,Legaspi JC

更新日期：2020-07-24 00:00:00

abstract：:Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

journal_title：Scientific reports

authors： Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

更新日期：2021-01-21 00:00:00

abstract：:The presence of non-poplar extracts, cutin, and wax layer in the wheat straw outer surface (WOS) greatly limit its application in bio-composite preparation. In this study, a dielectric-barrier-discharge plasma using water vapor as feeding gas was used to fast modify the WOS. The morphology, free radical concentrations...

journal_title：Scientific reports

authors： Chen W,Xu Y,Shi S,Cao Y,Chen M,Zhou X

更新日期：2018-02-02 00:00:00

abstract：:We present a new method for the design of devices to manipulate the displacement field in Elastic materials. It consists of solving a nonlinear optimization problem where the objective function defines the error in matching a desired displacement field, and the design variables determine the required material distribu...

journal_title：Scientific reports

authors： Fachinotti VD,Peralta I,Albanesi AE

更新日期：2018-06-29 00:00:00

abstract：:In this study, we evaluated the sink and source of the surface water along the PRE using a mixing model method with salinity as tracer. The observational data showed that the decreasing of dissolved inorganic nitrogen (DIN) did not closely follow the physical mixing lines of freshwater and modified seawater. In the we...

journal_title：Scientific reports

authors： Wu ML,Hong YG,Yin JP,Dong JD,Wang YS

更新日期：2016-11-11 00:00:00

abstract：:We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...

journal_title：Scientific reports

authors： Yin L,Deng G,Mente A,Sun Y,Liu X,Zhang X,Wang X,Wang Y,Bo J,Chen H,Liu X,Gao N,Bai X,Rangarajan S,Li W

更新日期：2018-04-30 00:00:00

abstract：:Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital ...

journal_title：Scientific reports

authors： Kandimalla R,Das M,Barge SR,Sarma PP,Koiri DJ,Devi A,Karki AK,Kumar A,Devi R,Pal BC,Talukdar NC,Samanta SK

更新日期：2020-11-18 00:00:00

abstract：:Ruminococcus albus 8 is a specialist plant cell wall degrading ruminal bacterium capable of utilizing hemicellulose and cellulose. Cellulose degradation requires a suite of enzymes including endoglucanases, exoglucanases, and β-glucosidases. The enzymes employed by R. albus 8 in degrading cellulose are yet to be compl...

journal_title：Scientific reports

authors： Iakiviak M,Devendran S,Skorupski A,Moon YH,Mackie RI,Cann I

更新日期：2016-07-21 00:00:00

abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...

journal_title：Scientific reports

authors： Peng X,Zhou R,Wang B,Yu X,Yang X,Liu K,Mi M

更新日期：2014-09-01 00:00:00

abstract：:Lightweight metastructures are designed consisting of prismatic tensegrity building blocks which have excellent strength-to-weight ratio and also enable unique compression-torsion coupling. A theoretical model with a coupled axial-torsional stiffness is first developed to study the band structures of the proposed ligh...

journal_title：Scientific reports

authors： Wang YT,Liu XN,Zhu R,Hu GK

更新日期：2018-07-31 00:00:00

abstract：:Underutilization due to performance limitations imposed by species and charge transports is one of the key issues that persist with various lithium-ion batteries. To elucidate the relevant mechanisms, two groups of characteristic parameters were proposed. The first group contains three characteristic time parameters, ...

journal_title：Scientific reports

authors： Jiang F,Peng P

更新日期：2016-09-07 00:00:00

abstract：:Diet composition impacts metabolic and cardiovascular health with high caloric diets contributing to obesity related disorders. Dietary interventions such as caloric restriction exert beneficial effects in the cardiovascular system, but alteration of which specific nutrient is responsible is less clear. This study inv...

journal_title：Scientific reports

authors： Hennig M,Ewering L,Pyschny S,Shimoyama S,Olecka M,Ewald D,Magarin M,Uebing A,Thierfelder L,Jux C,Drenckhahn JD

更新日期：2019-10-22 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia characterized by the formation of amyloid plaques (Aβ). Over the last decade, the important role of the innate immune system for the disease development has been established. Chronic activation of microglial cells creates a proinflammatory environment, which...

journal_title：Scientific reports

authors： Boza-Serrano A,Yang Y,Paulus A,Deierborg T

更新日期：2018-01-24 00:00:00

abstract：:Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which ...

journal_title：Scientific reports

authors： Kisu I,Emoto K,Masugi Y,Yamada Y,Matsubara K,Obara H,Matoba Y,Banno K,Kato Y,Saiki Y,Itagaki I,Kawamoto I,Iwatani C,Murase M,Nakagawa T,Tsuchiya H,Ishigaki H,Urano H,Ema M,Ogasawara K,Aoki D,Nakagawa K,Shiina

更新日期：2020-08-17 00:00:00

abstract：:Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of these lines with their other properties. The analysis revealed a r...

journal_title：Scientific reports

authors： Zielinski DC,Jamshidi N,Corbett AJ,Bordbar A,Thomas A,Palsson BO

更新日期：2017-01-25 00:00:00

abstract：:In the dominant livestock systems of Sahelian countries herds have to move across territories. Their mobility is often a source of conflict with farmers in the areas crossed, and helps spread diseases such as Rift Valley Fever. Knowledge of the routes followed by herds is therefore core to guiding the implementation o...

journal_title：Scientific reports

authors： Jahel C,Lenormand M,Seck I,Apolloni A,Toure I,Faye C,Sall B,Lo M,Diaw CS,Lancelot R,Coste C

更新日期：2020-05-20 00:00:00

abstract：:Landscape's spatial structure has vast implications for the dynamics and distribution of species populations and ecological communities. However, the characterization of the structure of spatial networks has not received nearly as much attention as networks of species interactions counterparts. Recent experiments show...

journal_title：Scientific reports

authors： Gilarranz LJ

更新日期：2020-05-26 00:00:00

abstract：:If the components of a battery, including electrodes, separator, electrolyte and the current collectors can be designed as paints and applied sequentially to build a complete battery, on any arbitrary surface, it would have significant impact on the design, implementation and integration of energy storage devices. Her...

journal_title：Scientific reports

authors： Singh N,Galande C,Miranda A,Mathkar A,Gao W,Reddy AL,Vlad A,Ajayan PM

更新日期：2012-01-01 00:00:00

abstract：:Self-aggregated Li4Ti5O12 particles sandwiched between graphene nanosheets (GNSs) and single-walled carbon nanotubes (SWCNTs) network are reported as new hybrid electrodes for high power Li-ion batteries. The multi-layer electrodes are fabricated by sequential process comprising air-spray coating of GNSs layer and the...

journal_title：Scientific reports

authors： Choi JH,Ryu WH,Park K,Jo JD,Jo SM,Lim DS,Kim ID

更新日期：2014-12-05 00:00:00

abstract：:During the Final Eneolithic the Corded Ware Complex (CWC) emerges, chiefly identified by its specific burial rites. This complex spanned most of central Europe and exhibits demographic and cultural associations to the Yamnaya culture. To study the genetic structure and kin relations in CWC communities, we sequenced th...

journal_title：Scientific reports

authors： Linderholm A,Kılınç GM,Szczepanek A,Włodarczak P,Jarosz P,Belka Z,Dopieralska J,Werens K,Górski J,Mazurek M,Hozer M,Rybicka M,Ostrowski M,Bagińska J,Koman W,Rodríguez-Varela R,Storå J,Götherström A,Krzewińska M

更新日期：2020-04-14 00:00:00

abstract：:Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...

journal_title：Scientific reports

authors： Buscardo E,Geml J,Schmidt SK,Freitas H,da Cunha HB,Nagy L

更新日期：2018-03-12 00:00:00

abstract：:Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk...

journal_title：Scientific reports

authors： Zhong X,Guo L,Zhang L,Li Y,He R,Cheng G

更新日期：2017-07-25 00:00:00

abstract：:Alcohol consumption has been shown to cause dysbiosis, but the mechanism involved in it is unknown. Recurrent colitis is known to induce expression of α-defensins in the colon, but the effect of alcohol consumption on it is not known. We investigated the effect of ethanol on α-defensin expression in the small intestin...

journal_title：Scientific reports

authors： Shukla PK,Meena AS,Rao V,Rao RG,Balazs L,Rao R

更新日期：2018-11-02 00:00:00