Abstract:
:Alcohol consumption has been shown to cause dysbiosis, but the mechanism involved in it is unknown. Recurrent colitis is known to induce expression of α-defensins in the colon, but the effect of alcohol consumption on it is not known. We investigated the effect of ethanol on α-defensin expression in the small intestine and colitis-induced expression in colon in mice. Furthermore, we evaluated the effect of human defensin-5 (HD5) on ethanol and colitis-induced gut barrier dysfunction and mucosal damage. Recurrent colitis was induced by feeding dextran sulfate sodium (DSS), 3 cycles of 5-days each with 15 days intervals, followed by 30-days remission. Ethanol was fed during the intervals and recovery in a liquid diet with or without HD5. Expression of α-defensins, tight junction (TJ) integrity and cytokine/chemokine expression were analyzed. Chronic ethanol feeding reduced α-defensin expression in the small intestine and colitis-induced defensin expression in the colon. HD5 attenuated the growth of enterotoxigenic Bacteriodes fragilis and E. coli, but had no effect on non-toxigenic Bacteriodes fragilis or probiotics, the Lactobacilli. Ethanol and colitis elevated Enterobacteriaceae, Firmicutes and Firmicutes to Bacteriodetes ratio in colonic mucosa. HD5 feeding attenuated ethanol and colitis-induced dysbiosis, disruption of intestinal epithelial TJ, mucosal inflammation, expression of pro-inflammatory cytokines and chemokines in the small intestine and colon, and endotoxemia. These results demonstrate that ethanol suppresses intestinal α-defensin expression, leading to dysbiosis, barrier dysfunction, inflammation and endotoxemia. HD5 feeding attenuates intestinal injury caused by ethanol and colitis, indicating that defensin expression is a potential target for treatment of alcoholic tissue injury and colitis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shukla PK,Meena AS,Rao V,Rao RG,Balazs L,Rao Rdoi
10.1038/s41598-018-34263-4subject
Has Abstractpub_date
2018-11-02 00:00:00pages
16241issue
1issn
2045-2322pii
10.1038/s41598-018-34263-4journal_volume
8pub_type
杂志文章abstract::One way of expediting materials development is to decrease the need for new experiments by making greater use of published literature. Here, we use data mining and automated image analysis to gather new insights on nanoporous gold (NPG) without conducting additional experiments or simulations. NPG is a three-dimension...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25122-3
更新日期:2018-04-30 00:00:00
abstract::The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64203-0
更新日期:2020-04-29 00:00:00
abstract::Here we developed an orange light-absorbing chromoprotein named ShadowR as a novel acceptor for performing fluorescence lifetime imaging microscopy-based Förster resonance energy transfer (FLIM-FRET) measurement in living cells. ShadowR was generated by replacing hydrophobic amino acids located at the surface of the c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48604-4
更新日期:2019-08-19 00:00:00
abstract::Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39757-3
更新日期:2019-03-01 00:00:00
abstract::Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32411
更新日期:2016-08-30 00:00:00
abstract::Anoectochilus roxburghii and Anoectochilus formasanus are the major species of genus Anoectochilus used in traditional Chinese medicine for their abundant content of flavonoids and some other medicinal constituents. In recent years, their wild resources are gradually exhausted due to over-collection and ecological det...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56821-0
更新日期:2019-12-27 00:00:00
abstract::It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16054-5
更新日期:2017-11-24 00:00:00
abstract::Iron oxide nanoparticles (IONPs) are known to induce cytotoxicity in various cancer cell lines through the generation of reactive oxygen species (ROS). However, the studies on its potential to induce toxicity in normal cell lines and in vivo system are limited and ambiguity still exists. Additionally, small molecules ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43188-5
更新日期:2019-05-06 00:00:00
abstract::Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology (ART) used for the treatment of infertility. Conventional bright fiel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39523-5
更新日期:2019-03-05 00:00:00
abstract::Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of these biofilms is alginate, a homo- and hetero-polysaccharide that consists of β-D-mannuronate (M) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66293-2
更新日期:2020-06-10 00:00:00
abstract::In this work, a broadband and broad-angle polarization-independent random coding metasurface structure is proposed for radar cross section (RCS) reduction. An efficient genetic algorithm is utilized to obtain the optimal layout of the unit cells of the metasurface to get a uniform backscattering under normal incidence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40782
更新日期:2017-01-20 00:00:00
abstract::The mechanism by which the Earth's magnetic field is generated is thought to be thermal convection in the metallic liquid iron core. Here we present results of a suite of self-consistent spherical shell computations with ultra-low viscosities that replicate this mechanism, but using diffusivities of momentum and magne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30864-1
更新日期:2018-08-22 00:00:00
abstract::The trade of bumble bees started in the early nineties for pollinator-dependent greenhouse plants. Nowadays, its rearing and transport have received public attention, since managed bees can transfer pathogens to wild bee populations. Therefore, guaranteeing pathogen-free bumble bees is fundamental. The major protein s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40804-2
更新日期:2019-03-12 00:00:00
abstract::Perpendicularly magnetized tunnel junctions (p-MTJs) that contain synthetic antiferromagnetic (SAF) frames show promise as reliable building blocks to meet the demands of perpendicular magnetic anisotropy (PMA)-based spintronic devices. In particular, Co/Pd multilayer-based SAFs have been widely employed due to their ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21324
更新日期:2016-02-18 00:00:00
abstract::Birds play unique functional roles in the maintenance of ecosystems, such as pollination and seed dispersal, and thus monitoring bird species diversity is a first step towards avoiding undesirable consequences of anthropogenic impacts on bird communities. In the present study, we hypothesized that birds, regardless of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22817-5
更新日期:2018-03-14 00:00:00
abstract::Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07424
更新日期:2014-12-11 00:00:00
abstract::The temperature dependence of the resistivity (ρ) of Ag-doped Bi2Se3 (AgxBi2-xSe3) shows insulating behavior above 35 K, but below 35 K, ρ suddenly decreases with decreasing temperature, in contrast to the metallic behavior for non-doped Bi2Se3 at 1.5-300 K. This significant change in transport properties from metalli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41906-7
更新日期:2019-03-29 00:00:00
abstract::Coral reefs across the world's oceans are in the midst of the longest bleaching event on record (from 2014 to at least 2016). As many of the world's reefs are remote, there is limited information on how past thermal conditions have influenced reef composition and current stress responses. Using satellite temperature d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38402
更新日期:2016-12-06 00:00:00
abstract::The effect of annealing both in the oxygen atmosphere and at room temperatures on physical properties such as the pseudogap (Δ*(T)) and excess conductivity (σ'(T)) of untwined YBa2Cu3O7-δ (YBCO) single crystal with a small deviation from oxygen stoichiometry is studied. It was revealed that as the charge carrier densi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45286-w
更新日期:2019-06-25 00:00:00
abstract::This study for the first time examined the prophylactic role of Tungrymbai, a well-known fermented soybean food of North-East India, against hepatic steatosis. Treatment with hexane-isopropanolic (2:1, HIET) but not hydro-alcoholic (70% ethanol, HAET) extract dose-dependently (0.1, 0.2, or 0.3 µg/mL) reduced the intra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27607-7
更新日期:2018-07-03 00:00:00
abstract::Ziziphus is a genus of spiny shrubs and small trees in the Rhamnaceae family. This group has a controversial taxonomy, with more than 200 species described, including Chinese jujube (Ziziphus jujuba Mill. var. jujuba) and Indian jujube (Z. mauritiana), as well as several other important cultivated fruit crops. Using 2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31503
更新日期:2016-08-17 00:00:00
abstract::In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tiss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08458-0
更新日期:2017-08-15 00:00:00
abstract::Giant optical transmittance changes of over 300% in wide wavelength range from 500 nm to 2500 nm were observed in LaBaCo2O5.5+δ thin films annealed in air and ethanol ambient, respectively. The reduction process induces high density of ordered oxygen vacancies and the formation of LaBaCo2O5.5 (δ = 0) structure evidenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37496
更新日期:2016-11-23 00:00:00
abstract::Competing endogenous RNA (ceRNA) have received wide attention because they are a novel way to regulate genes through sharing microRNAs (miRNAs) that are crucial for complex processes in many diseases. However, no systematic analysis of ceRNA mechanism in cardiovascular disease (CVD) is known. To gain insights into the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10547-z
更新日期:2017-08-31 00:00:00
abstract::The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25445-1
更新日期:2018-05-14 00:00:00
abstract::The Gram-negative bacterium B. pertussis is the causative agent of whooping cough. This infection is re-emerging and new features related to Bordetella pathogenesis and microbiology could be relevant to defeat it. Therefore, we focused our attention on BP1253, a predicted exported protein from B. pertussis erroneously...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53171-9
更新日期:2019-11-19 00:00:00
abstract::Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development of obesity and insulin resistance upon aging or dietary c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20453
更新日期:2016-02-09 00:00:00
abstract::Plant chloroplasts proliferate through binary fission, and the stromal-side molecules that are involved in chloroplast division are bacterial derivatives. As in bacteria, the prokaryotic tubulin homolog FtsZ assembles into a ring-like structure (Z ring) at mid-chloroplast, and this process is followed by constriction....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03698-6
更新日期:2017-06-14 00:00:00
abstract::The limits of mammography have led to an increasing interest on possible alternatives such as the breast Computed Tomography (bCT). The common goal of all X-ray imaging techniques is to achieve the optimal contrast resolution, measured through the Contrast to Noise Ratio (CNR), while minimizing the radiological risks,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49351-2
更新日期:2019-09-11 00:00:00
abstract::Individuals who have prior history of childhood traumatic experiences are at a high risk for a variety of psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether such individuals exhibit altered cortical functional networks during a behavioral inhibition task. One hundr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28329-6
更新日期:2018-07-04 00:00:00