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Altered cortical functional network during behavioral inhibition in individuals with childhood trauma.

Abstract：

:Individuals who have prior history of childhood traumatic experiences are at a high risk for a variety of psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether such individuals exhibit altered cortical functional networks during a behavioral inhibition task. One hundred fifty-three non-clinical individuals were recruited and instructed to perform a Go/NoGo task during an electroencephalograph. Source-level weighted functional networks based on the graph theory were analyzed for NoGo-P3 processing. Based on their total scores on the childhood trauma questionnaire (CTQ) participants were divided into three groups: low CTQ, middle CTQ, and high CTQ. Results at the global level indicated decreased strength, clustering coefficient, and efficiency for the low and gamma bands in the high CTQ group. In addition, the path length of the low beta band was observed to be longer in the high CTQ group than the low CTQ group. At the nodal level, the nodal clustering coefficient of high CTQ group was decreased in left primary somatosensory cortex and middle occipital gyrus for the low beta band, and in left superior temporal gyrus for the gamma band. The nodal clustering coefficient of the left primary somatosensory cortex showed a significant negative correlation with the total CTQ score for the low beta band. In addition, the nodal clustering coefficient of the left middle occipital gyrus for the low beta band and superior temporal gyrus for the gamma band showed significant negative correlations with the emotional neglect score. Our results demonstrate an altered cortical functional network in individuals who experienced childhood trauma. In particular, the left primary somatosensory cortex, middle occipital gyrus, and superior temporal gyrus were found to be vulnerable in individuals who experienced childhood trauma, especially emotional neglect.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim S,Kim JS,Shim M,Im CH,Lee SH

doi

10.1038/s41598-018-28329-6

subject

Has Abstract

pub_date

2018-07-04 00:00:00

pages

10123

issue

1

issn

2045-2322

pii

10.1038/s41598-018-28329-6

journal_volume

8

pub_type

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