Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field.

abstract：:Spinal Muscular Atrophy (SMA) is a monogenic neurodegenerative disorder and the leading genetic cause of infantile mortality. While several functions have been ascribed to the SMN (survival motor neuron) protein, their specific contribution to the disease has yet to be fully elucidated. We hypothesized that some, but ...

journal_title：Scientific reports

authors： Osman EY,Bolding MR,Villalón E,Kaifer KA,Lorson ZC,Tisdale S,Hao Y,Conant GC,Pires JC,Pellizzoni L,Lorson CL

更新日期：2019-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Tsuchiya K,Suzuki Y,Yoshimura K,Yasui H,Karayama M,Hozumi H,Furuhashi K,Enomoto N,Fujisawa T,Nakamura Y,Inui N,Yokomura K,Suda T

更新日期：2020-02-19 00:00:00

abstract：:Antibiotic resistance, a consequence of antibiotic use, is a threat to health, with severe consequences for resource constrained settings. If determinants for human antibiotic use in India, a lower middle income country, with one of the highest antibiotic consumption in the world could be understood, interventions cou...

journal_title：Scientific reports

authors： Tamhankar AJ,Karnik SS,Stålsby Lundborg C

更新日期：2018-04-23 00:00:00

abstract：:After injury to the mature central nervous system (CNS), myelin-derived inhibitory ligands bind to the Nogo-66 tripartite receptor complex expressed on axonal growth cones, comprised of LINGO-1 and p75NTR/TROY and induce growth cone collapse through the RhoA pathway. We have also shown that amphoterin-induced gene and...

journal_title：Scientific reports

authors： Almutiri S,Berry M,Logan A,Ahmed Z

更新日期：2018-07-16 00:00:00

abstract：:Animals that experience situations likely to induce negative emotions show changes in judgment associated with pessimism. Few studies have focused on whether animals express stable differences in pessimism and whether these differences are related to personality traits. The first aim of this study was to explore if da...

journal_title：Scientific reports

authors： Lecorps B,Weary DM,von Keyserlingk MAG

更新日期：2018-01-23 00:00:00

abstract：:Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-en...

journal_title：Scientific reports

authors： Wang Y,Duan Z,Qiu Z,Zhang P,Wu J,Zhang D,Xiang T

更新日期：2017-08-21 00:00:00

abstract：:Clostridial neurotoxins (CNTs), which include botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT), are the most potent toxins known to science and are the causative agents of botulism and tetanus, respectively. The evolutionary origins of CNTs and their relationships to other proteins remains an intriguing que...

journal_title：Scientific reports

authors： Mansfield MJ,Wentz TG,Zhang S,Lee EJ,Dong M,Sharma SK,Doxey AC

更新日期：2019-02-07 00:00:00

abstract：:The interest in nanostructures of silicon and its dopants has significantly increased. We report the creation of an ultimately-shallow junction at the surface of n-type silicon with excellent electrical and optical characteristics made by depositing an atomically thin boron layer at a relatively low temperature where ...

journal_title：Scientific reports

authors： Mohammadi V,Nihtianov S,Fang C

更新日期：2017-10-16 00:00:00

abstract：:Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly un...

journal_title：Scientific reports

authors： Matis BR,Houston BH,Baldwin JW

更新日期：2017-07-18 00:00:00

abstract：:High-quality GaN epitaxial films have been grown on Si substrates with Al buffer layer by the combination of molecular beam epitaxy (MBE) and pulsed laser deposition (PLD) technologies. MBE is used to grow Al buffer layer at first, and then PLD is deployed to grow GaN epitaxial films on the Al buffer layer. The surfac...

journal_title：Scientific reports

authors： Wang W,Wang H,Yang W,Zhu Y,Li G

更新日期：2016-04-22 00:00:00

abstract：:The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this stud...

journal_title：Scientific reports

authors： Cave R,Misra R,Chen J,Wang S,Mkrtchyan HV

更新日期：2019-08-01 00:00:00

abstract：:We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange resin) or differential precipitation (salting out), respectively. The choice of extraction kit had ...

journal_title：Scientific reports

authors： Becker L,Steglich M,Fuchs S,Werner G,Nübel U

更新日期：2016-06-17 00:00:00

abstract：:Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the n...

journal_title：Scientific reports

authors： Malabirade A,Partouche D,El Hamoui O,Turbant F,Geinguenaud F,Recouvreux P,Bizien T,Busi F,Wien F,Arluison V

更新日期：2018-11-14 00:00:00

abstract：:Hyperspectral imaging (HSI) is being explored in endoscopy as a tool to extract biochemical information that may improve contrast for early cancer detection in the gastrointestinal tract. Motion artefacts during medical endoscopy have traditionally limited HSI application, however, recent developments in the field hav...

journal_title：Scientific reports

authors： Grigoroiu A,Yoon J,Bohndiek SE

更新日期：2020-03-03 00:00:00

abstract：:The whale shark (Rhincodon typus) is an endangered species with a declining global population. The South Ari Atoll Marine Protected Area (SAMPA), Maldives, is one of few locations globally where year-long residency of individuals occurs. This SAMPA aggregation appears to consist almost exclusively of immature males. D...

journal_title：Scientific reports

authors： Harvey-Carroll J,Stewart JD,Carroll D,Mohamed B,Shameel I,Zareer IH,Araujo G,Rees R

更新日期：2021-01-13 00:00:00

abstract：:Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...

journal_title：Scientific reports

authors： Kang S,Kim J,Chang KA

更新日期：2021-01-14 00:00:00

abstract：:Despite growing acknowledgement of the role of oxidized fatty acids (oxFA) as cellular signaling molecules and in the pathogenesis of disease, developing methods to measure these species in biological samples has proven challenging. Here we describe a novel method utilizing HPLC-ESI-MS/MS to identify and quantify mult...

journal_title：Scientific reports

authors： Ahern KW,Serbulea V,Wingrove CL,Palas ZT,Leitinger N,Harris TE

更新日期：2019-08-01 00:00:00

abstract：:The SLRP opticin (OPTC) has been demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here, we investigated the in vivo effect of OPTC deficiency in OA cartilage. OA was induced in 10-week-old Optc -/- and Optc +/+ mice. Ten weeks post-surgery, cartilage was processed for histology and immu...

journal_title：Scientific reports

authors： Farrán A,Valverde-Franco G,Tío L,Lussier B,Fahmi H,Pelletier JP,Bishop PN,Monfort J,Martel-Pelletier J

更新日期：2018-01-11 00:00:00

abstract：:Sensitive in situ detection of organic molecules is highly demanded in environmental monitoring. In this work, the surface enhanced Raman spectroscopy (SERS) is adopted in microfluidics to detect the organic molecules with high accuracy and high sensitivity. Here the SERS substrate in microchannel consists of Ag nanop...

journal_title：Scientific reports

authors： Zhang X,Zhang H,Yan S,Zeng Z,Huang A,Liu A,Yuan Y,Huang Y

更新日期：2019-11-27 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend i...

journal_title：Scientific reports

authors： Tanoue M,Hirabayashi Y,Ikeuchi H

更新日期：2016-10-26 00:00:00

abstract：:The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumou...

journal_title：Scientific reports

authors： Girigoswami A,Yassine W,Sharmiladevi P,Haribabu V,Girigoswami K

更新日期：2018-11-07 00:00:00

abstract：:Methane concentration in caves is commonly much lower than the external atmosphere, yet the cave CH4 depletion causal mechanism is contested and dynamic links to external diurnal and seasonal temperature cycles unknown. Here, we report a continuous 3-year record of cave methane and other trace gases in Jenolan Caves, ...

journal_title：Scientific reports

authors： Waring CL,Hankin SI,Griffith DWT,Kertesz MA,Kobylski V,Wilson NL,Coleman NV,Kettlewell G,Zlot R,Bosse M,Bell G

更新日期：2017-08-16 00:00:00

abstract：:Since its recent foundation, phase-coherent caloritronics has sparkled continuous interest giving rise to numerous concrete applications. This research field deals with the coherent manipulation of heat currents in mesoscopic superconducting devices by mastering the Josephson phase difference. Here, we introduce a new...

journal_title：Scientific reports

authors： Guarcello C,Solinas P,Braggio A,Giazotto F

更新日期：2018-08-16 00:00:00

abstract：:We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...

journal_title：Scientific reports

authors： Guazzini A,Stefanelli F,Imbimbo E,Vilone D,Bagnoli F,Levnajić Z

更新日期：2019-04-02 00:00:00

abstract：:The potency of cellular immune responses strongly depends on T cell avidity to antigen. Yet, functional avidity measurements are rarely performed in patients, mainly due to the technical challenges of characterizing heterogeneous T cells. The mean functional T cell avidity can be determined by the IFN-γ Elispot assay,...

journal_title：Scientific reports

authors： Ioannidou K,Baumgaertner P,Gannon PO,Speiser MF,Allard M,Hebeisen M,Rufer N,Speiser DE

更新日期：2017-03-13 00:00:00

abstract：:Vaccines have become fundamental in the control and elimination of Glässer Disease, a systemic disease of pigs caused by Haemophilus parasuis. The classic vaccines available for prevention of this infection were developed without a robust knowledge about host immunological mechanisms. In this study, we demonstrated th...

journal_title：Scientific reports

authors： Barasuol BM,Guizzo JA,Fegan JE,Martínez-Martínez S,Rodríguez-Ferri EF,Gutiérrez-Martín CB,Kreutz LC,Schryvers AB,Frandoloso R

更新日期：2017-09-04 00:00:00

abstract：:Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites were synthesised by co-precipitating iron salts onto GO sheets in basic solution. The results showed that formation of two distinct structures was dependent upon the GO loading. The first structure corresponds to a low GO loading up to 10 wt%, associated with the ben...

journal_title：Scientific reports

authors： Zubir NA,Yacou C,Motuzas J,Zhang X,Diniz da Costa JC

更新日期：2014-04-04 00:00:00

abstract：:Automated vehicles (AVs) will change the role of the driver, from actively controlling the vehicle to primarily monitoring it. Removing the driver from the control loop could fundamentally change the way that drivers sample visual information from the scene, and in particular, alter the gaze patterns generated when un...

journal_title：Scientific reports

authors： Mole C,Pekkanen J,Sheppard WEA,Markkula G,Wilkie RM

更新日期：2021-01-08 00:00:00

abstract：:Clinical differentiation between cystic lesions of endodontic and non-endodontic origin is of importance because correct diagnosis may affect treatment decision making. Most radicular cysts are treated with conservative approaches and, therefore, are not surgically removed. The objective of this study was to determine...

journal_title：Scientific reports

authors： Tsesis I,Krepel G,Koren T,Rosen E,Kfir A

更新日期：2020-08-25 00:00:00