Differential landscape of non-CpG methylation in embryonic stem cells and neurons caused by DNMT3s.

abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

journal_title：Scientific reports

authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

更新日期：2019-04-04 00:00:00

abstract：:The SELEX (Systematic Evolution of Ligands by EXponential enrichment) method has been used successfully since 1990, but work is still required to obtain highly specific aptamers. Here, we present a novel approach called 'Competitive non-SELEX' (and termed as 'SELCOS' (Systematic Evolution of Ligands by COmpetitive Sel...

journal_title：Scientific reports

authors： Kushwaha A,Takamura Y,Nishigaki K,Biyani M

更新日期：2019-04-30 00:00:00

abstract：:Accurate intraocular lens (IOL) power calculation is always a challenge in ophthalmology, and unoptimized process may lead to inaccurate refractive outcomes. Quality control circle (QCC) has shown its success in many fields as a process management tool. However, its efficacy in ophthalmology remains unclear. Here we u...

journal_title：Scientific reports

authors： Lin L,Chang P,Xie J,Li Z,Zhang H,Lu F,Zhao YE

更新日期：2017-11-01 00:00:00

abstract：:The need for sensitive, robust, portable, and inexpensive biosensing platforms is of significant interest in clinical applications for disease diagnosis and treatment monitoring at the point-of-care (POC) settings. Rapid, accurate POC diagnostic assays play a crucial role in developing countries, where there are limit...

journal_title：Scientific reports

authors： Shafiee H,Asghar W,Inci F,Yuksekkaya M,Jahangir M,Zhang MH,Durmus NG,Gurkan UA,Kuritzkes DR,Demirci U

更新日期：2015-03-06 00:00:00

abstract：:Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss in mammals become paramount for hearing protection. Here we reported that, by using a well-established gentamicin-induced hair cell loss mode...

journal_title：Scientific reports

authors： Quan Y,Xia L,Shao J,Yin S,Cheng CY,Xia W,Gao WQ

更新日期：2015-02-02 00:00:00

abstract：:Post-transplant cyclophosphamide has become a promising medical option after allogeneic HSCT. In this study we aimed to evaluate the efficacy of cyclophosphamide and cyclosporine combination in acute and chronic graft-versus-host disease (GvHD) prophylaxis in acute myeloid leukemia (AML) cases scheduled for allogeneic...

journal_title：Scientific reports

authors： Namdaroglu S,Kaya AH,Batgi H,Kayikci O,Dal MS,Iskender D,Kizil Cakar M,Tekgunduz E,Altuntas F

更新日期：2019-02-14 00:00:00

abstract：:Mapping near-field profiles and dynamics of surface plasmon polaritons is crucial for understanding their fundamental optical properties and designing miniaturized photonic devices. This requires a spatial resolution on the sub-wavelength scale because the effective polariton wavelength is shorter than free-space exci...

journal_title：Scientific reports

authors： Du L,Lei DY,Yuan G,Fang H,Zhang X,Wang Q,Tang D,Min C,Maier SA,Yuan X

更新日期：2013-10-29 00:00:00

abstract：:Core-shell Nb2O5/TiO2 composite with hierarchical heterostructure is successfully synthesized In-situ by a facile template-free and acid-free solvothermal method based on the mechanism of liquid phase epitaxy. The chemical circumstance change induced by the alcoholysis of NbCl5 is utilized tactically to trigger core-s...

journal_title：Scientific reports

authors： Wen Z,Wang G

更新日期：2016-04-28 00:00:00

abstract：:Occlusion of the middle cerebral artery (MCA) by an intraluminal filament is widely used to study focal brain ischemia in male Sprague-Dawley rats. However, permanent occlusion goes along with a high fatality. To overcome this drawback we designed a new filament carrying a bowling pin-shaped tip (BP-tip) and compared ...

journal_title：Scientific reports

authors： Shanbhag NC,Henning RH,Schilling L

更新日期：2016-06-22 00:00:00

abstract：:Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy ...

journal_title：Scientific reports

authors： Wang M,Gong Q,Zhang J,Chen L,Zhang Z,Lu L,Yu D,Han Y,Zhang D,Chen P,Zhang X,Yuan Z,Huang J,Zhang X

更新日期：2017-03-06 00:00:00

abstract：:Urbanization-driven landscape changes are harmful to many species. Negative effects can be mitigated through habitat preservation and restoration, but it is often difficult to prioritize these conservation actions. This is due, in part, to the scarcity of species response data, which limit the predictive accuracy of m...

journal_title：Scientific reports

authors： Ettinger AK,Buhle ER,Feist BE,Howe E,Spromberg JA,Scholz NL,Levin PS

更新日期：2021-01-12 00:00:00

abstract：:In South American societies, domesticated camelids were of great cultural importance and subject to trade and translocation. South American camelids were even found on remote and hard to reach islands, emphasizing their importance to historic and pre-historic South American populations. Isla Mocha, a volcanic island 3...

journal_title：Scientific reports

authors： Westbury M,Prost S,Seelenfreund A,Ramírez JM,Matisoo-Smith EA,Knapp M

更新日期：2016-12-08 00:00:00

abstract：:Clinical practice guides recommend delayed clamping of the umbilical cord. If this is not possible, some authors suggest milking as an alternative. The objective of this study was to determine the variability in professional practice in the management of umbilical cord clamping and milking and to identify factors or c...

journal_title：Scientific reports

authors： Ortiz-Esquinas I,Gómez-Salgado J,Pascual-Pedreño AI,Rodríguez-Almagro J,Ballesta-Castillejos A,Hernández-Martínez A

更新日期：2020-02-03 00:00:00

abstract：:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an...

journal_title：Scientific reports

authors： Fan Q,Zhang Y,Hu L,Sun Q,Cui H,Yan D,Sikandaner H,Tang H,Wang D,Zhu Z,Zhu S,Xu W

更新日期：2015-12-21 00:00:00

abstract：:The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sam...

journal_title：Scientific reports

authors： Frühbeck G,Catalán V,Rodríguez A,Ramírez B,Becerril S,Salvador J,Portincasa P,Colina I,Gómez-Ambrosi J

更新日期：2017-07-26 00:00:00

abstract：:Ultrasound imaging is affected by coherent noise or speckle, which reduces contrast and overall image quality and degrades the diagnostic precision of the collected images. Elevational angular compounding (EAC) is an attractive means of addressing this limitation, since it reduces speckle noise while operating in real...

journal_title：Scientific reports

authors： Afshari P,Zakian C,Ntziachristos V

更新日期：2020-10-23 00:00:00

abstract：:Nanoscale real-time molecular sensing requires large signal enhancement, small background, short detection time and high spectral resolution. We demonstrate a new vibrational spectroscopic technique which satisfies all of these conditions. This time-resolved surface-enhanced coherent anti-Stokes Raman scattering (tr-S...

journal_title：Scientific reports

authors： Voronine DV,Sinyukov AM,Hua X,Wang K,Jha PK,Munusamy E,Wheeler SE,Welch G,Sokolov AV,Scully MO

更新日期：2012-01-01 00:00:00

abstract：:Self-assembly of biological molecules on solid materials is central to the "bottom-up" approach to directly integrate biology with electronics. Inspired by biology, exquisite biomolecular nanoarchitectures have been formed on solid surfaces. We demonstrate that a combinatorially-selected dodecapeptide and its variants...

journal_title：Scientific reports

authors： Hayamizu Y,So CR,Dag S,Page TS,Starkebaum D,Sarikaya M

更新日期：2016-09-22 00:00:00

abstract：:Ossification of the posterior longitudinal ligament (OPLL) can occur throughout the entire spine and can sometimes lead to spinal disorder. Although patients with OPLL sometimes develop physical limitations because of pain, the characteristics of pain and effects on activities of daily living (ADL) have not been preci...

journal_title：Scientific reports

authors： Hirai T,Yoshii T,Ushio S,Mori K,Maki S,Katsumi K,Nagoshi N,Takeuchi K,Furuya T,Watanabe K,Nishida N,Watanabe K,Kaito T,Kato S,Nagashima K,Koda M,Ito K,Imagama S,Matsuoka Y,Wada K,Kimura A,Ohba T,Katoh H,Mats

更新日期：2020-03-26 00:00:00

abstract：:Circulation through cerebral collaterals can maintain tissue viability until reperfusion is achieved. However, collateral circulation is time limited, and failure of collaterals is accelerated in the aged. Remote ischemic perconditioning (RIPerC), which involves inducing a series of repetitive, transient peripheral cy...

journal_title：Scientific reports

authors： Ma J,Ma Y,Shuaib A,Winship IR

更新日期：2020-07-24 00:00:00

abstract：:We have studied the intrinsic fluorescence spectra of a monomeric variant of human transthyretin (M-TTR), a protein involved in the transport of the thyroid hormone and retinol and associated with various forms of amyloidosis, extending our analysis to the second order derivative of the spectra. This procedure allowed...

journal_title：Scientific reports

authors： Jazaj D,Ghadami SA,Bemporad F,Chiti F

更新日期：2019-07-29 00:00:00

abstract：:The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...

journal_title：Scientific reports

authors： Behera MK,Williams LC,Pradhan SK,Bahoura M

更新日期：2020-02-04 00:00:00

abstract：:Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing 52gM...

journal_title：Scientific reports

authors： Graves SA,Hernandez R,Valdovinos HF,Ellison PA,Engle JW,Barnhart TE,Cai W,Nickles RJ

更新日期：2017-06-08 00:00:00

abstract：:Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...

journal_title：Scientific reports

authors： Lei X,Yu J,Niu Q,Liu J,Fraering PC,Wu F

更新日期：2015-11-16 00:00:00

abstract：:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a ...

journal_title：Scientific reports

authors： Huang X,Wei H,Wu S,Du Y,Liu L,Su J,Xu Y,Wang H,Li X,Wang Y,Liu G,Chen W,Klena JD,Xu B

更新日期：2015-03-10 00:00:00

abstract：:The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3 show that these proteins interact with TEAD via a conserved amino acid motif called the TONDU domain. Surprisingly, our stud...

journal_title：Scientific reports

authors： Mesrouze Y,Aguilar G,Bokhovchuk F,Martin T,Delaunay C,Villard F,Meyerhofer M,Zimmermann C,Fontana P,Wille R,Vorherr T,Erdmann D,Furet P,Scheufler C,Schmelzle T,Affolter M,Chène P

更新日期：2020-10-15 00:00:00

abstract：:Because of ubiquity of thioesters, thioesterases play a critical role in metabolism, membrane biosynthesis, signal transduction, and gene regulation. In many bacteria, YbgC is such an enzyme, whose coding gene mostly resides in the tol-pal cluster. Although all other proteins encoded in the tol-pal cluster are clearly...

journal_title：Scientific reports

authors： Gao T,Meng Q,Gao H

更新日期：2017-06-21 00:00:00

abstract：:A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether the...

journal_title：Scientific reports

authors： Zhang H,Shi X,Wang L,Li X,Zheng C,Gao B,Xu X,Lin X,Wang J,Lin Y,Shi J,Huang Q,Luo Z,Yang L

更新日期：2018-03-01 00:00:00

abstract：:A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a tech...

journal_title：Scientific reports

authors： Cao Y,Liao S,Zeng H,Ni S,Tintani F,Hao Y,Wang L,Wu T,Lu H,Duan C,Hu J

更新日期：2017-03-07 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that mediates phosphoinositide-3-kinase (PI3K)/AKT signalling. This pathway is involved in a plethora of cellular functions including protein and lipid synthesis, cell migration, cell proliferation and apoptosis. In this study, we proposed to ...

journal_title：Scientific reports

authors： Malik N,Dunn KM,Cassels J,Hay J,Estell C,Sansom OJ,Michie AM

更新日期：2019-11-15 00:00:00