Abstract：
:Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult-to-treat infection. Increasing efforts have been taken to mitigate the epidemics and to avoid potential outbreaks in low endemic settings. Understanding the population dynamics of MRSA is essential to identify the causal mechanisms driving the epidemics and to generalise conclusions to different contexts. Previous studies neglected the temporal structure of contacts between patients and assumed homogeneous behaviour. We developed a high-resolution data-driven contact network model of interactions between 743,182 patients in 485 hospitals during 3,059 days to reproduce the exact contact sequences of the hospital population. Our model captures the exact spatial and temporal human contact behaviour and the dynamics of referrals within and between wards and hospitals at a large scale, revealing highly heterogeneous contact and mobility patterns of individual patients. A simulation exercise of epidemic spread shows that heterogeneous contacts cause the emergence of super-spreader patients, slower than exponential polynomial growth of the prevalence, and fast epidemic spread between wards and hospitals. In our simulated scenarios, screening upon hospital admittance is potentially more effective than reducing infection probability to reduce the final outbreak size. Our findings are useful to understand not only MRSA spread but also other hospital-acquired infections.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Rocha LEC,Singh V,Esch M,Lenaerts T,Liljeros F,Thorson Adoi
10.1038/s41598-020-66270-9subject
Has Abstractpub_date
2020-06-09 00:00:00pages
9336issue
1issn
2045-2322pii
10.1038/s41598-020-66270-9journal_volume
10pub_type
杂志文章abstract：:Soil respiration (Rs) is an important source of atmospheric CO2 flux and is sensitive to changes in soil nutrient and water contents. Despite extensive studies on the effects of enhanced atmospheric nitrogen (N) deposition and changes in precipitation (P) on Rs, few studies have taken into account the effects of inter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34969-5
更新日期：2018-11-08 00:00:00
abstract：:It has been recently shown that scores of physical and chemical phenomena (including spontaneous emission, scattering and Förster energy transfer) can be controlled by nonlocal dielectric environments provided by metamaterials with hyperbolic dispersion and simpler metal/dielectric structures. At this time, we have re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27834
更新日期：2016-06-21 00:00:00
abstract：:High stable C/S composites are fabricated by a novel high-temperature sulfur infusion into micro-mesoporous carbon method following with solvent cleaning treatment. The C/S composite cathodes show high Coulombic efficiency, long cycling stability and good rate capability in the electrolyte of 1.0 M LiPF6 + EC/DEC (1:1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04842
更新日期：2014-04-29 00:00:00
abstract：:We present a comprehensive study of a magnetic sensor system that benefits from a new technique to substantially increase the magnetoelastic coupling of surface acoustic waves (SAW). The device uses shear horizontal acoustic surface waves that are guided by a fused silica layer with an amorphous magnetostrictive FeCoS...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18441-4
更新日期：2018-01-10 00:00:00
abstract：:The voltage-gated sodium channel isoform NaV1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission. Genetic gain-of-function and loss-of-function NaV1.7 mutations have been identified in select individuals, and are associated with episodic extreme pain disorders a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71135-2
更新日期：2020-09-09 00:00:00
abstract：:Although differentiated thyroid carcinoma (DTC) has a good prognosis and survival rate, long-term medication and recurrence monitoring might be needed. The factors that affect postoperative health-related quality of life (HRQoL) in patients with DTC in different regions remain unclear or conflicting. The purpose of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62731-3
更新日期：2020-04-01 00:00:00
abstract：:SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants are associated with abnormally low milk Zn levels and can lead to severe infa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21505-8
更新日期：2018-02-23 00:00:00
abstract：:Dairy cows are often fed a high-concentrate (HC) diet to meet lactation demands; however, long-term concentrate feeding is unhealthy and decreases milk fat. Therefore, we investigated the effects of liver lipid metabolism on milk fat synthesis. Ten lactating Holstein cows were assigned randomly into HC and LC (low-con...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44217
更新日期：2017-03-13 00:00:00
abstract：:Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32993
更新日期：2016-09-12 00:00:00
abstract：:A classic example of solid-state topochemical reactions is the ultraviolet-light induced photodimerization of α-trans-cinnamic acid (CA). Here, we report the first observation of an X-ray-induced dimerization of CA and monitor it in situ using nonresonant inelastic X-ray scattering spectroscopy (NRIXS). The time-evolu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15851
更新日期：2015-11-16 00:00:00
abstract：:Pre-clinical monitoring of tumor growth and identification of distal metastasis requires a balance between accuracy and expediency. Bioluminescence imaging (BLI) is often used to track tumor growth but is primarily limited to planar 2-dimensional (2D) imaging. Consistent subject placement within a standard top-mounted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21668-4
更新日期：2018-02-20 00:00:00
abstract：:Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10328-8
更新日期：2017-08-25 00:00:00
abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27630
更新日期：2016-06-08 00:00:00
abstract：:This study investigated the efficacy of a biphasic synthetic β-tricalcium phosphate/calcium sulfate (β-TCP/CS) bone graft substitute for compatibility with vancomycin (V) in combination with tobramycin (T) or gentamicin (G) evidenced by the duration of potency and the prevention and killing efficacies of P. aeruginosa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80764-6
更新日期：2021-01-14 00:00:00
abstract：:Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22643
更新日期：2016-03-04 00:00:00
abstract：:Adult stem cells are considered promising candidates for cellular therapies due to their capacity to differentiate and self-renew. Differentiation leads to changes in the metabolism, structure, and gene expression patterns of cells. Hedgehog is one of the pathways that is involved in the enhancement of osteogenesis an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26533-y
更新日期：2018-05-30 00:00:00
abstract：:Both between- and within-individual variation in behaviour can be important in determining mating opportunities and reproductive outcomes. Such behavioural variability can be induced by environmental conditions, especially if individuals vary in their tolerance levels or resource allocation patterns. We tested the eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27651-3
更新日期：2018-06-19 00:00:00
abstract：:Temporal precision is a determinant of performance in various motor activities. Although the accuracy and precision of timing in activities have been previously measured and quantified, temporal dynamics with flexible precision have not been considered. Here, we examined the temporal dynamics in timed motor activities...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76953-y
更新日期：2020-11-18 00:00:00
abstract：:The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. Analysis of cross-sectional self-report and faecal microbial data from 274 patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19171
更新日期：2016-01-13 00:00:00
abstract：:Pre-stimulus alpha (8-12 Hz) and beta (16-20 Hz) oscillations have been frequently linked to the prediction of upcoming sensory input. Do these frequency bands serve as a neural marker of linguistic prediction as well? We hypothesized that if pre-stimulus alpha and beta oscillations index language predictions, their p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56600-x
更新日期：2019-12-27 00:00:00
abstract：:Melon (Cucumis melo L.) is a very important crop throughout the world and has great economic importance, in part due to its nutritional properties. It prefers well-drained soil with low acidity and has a strong demand for water during fruit set. Therefore, a correct water balance-involving aquaporins-is necessary to m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79250-w
更新日期：2020-12-17 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is an important component of neuroendocrine stress regulation and coping behavior. Transcriptome profiles of the hypothalamus and adrenal gland were assessed to identify molecular pathways and candidate genes for coping behavior in pigs. Ten each of high- (HR) and low- (LR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49521-2
更新日期：2019-09-10 00:00:00
abstract：:We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3- effector T-cells (Teff), when CD4+ T-cells are co-cultured with GM-CSF derived bone marrow dendritic cells (G-BMDCs). Events downstream of OX40L/OX40 interaction in Tregs respons...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05254-8
更新日期：2017-07-26 00:00:00
abstract：:The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37567
更新日期：2016-11-23 00:00:00
abstract：:In the northeastern United States, chronic wasting disease has recently been detected in white-tailed deer (Odocoileus virginianus) populations, and understanding the relationship between landscape configuration and home range may improve disease surveillance and containment efforts. The objectives of our study were t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32937-7
更新日期：2018-10-02 00:00:00
abstract：:The damping properties and specifically the bend losses of polymer optical fibres (POFs) have so far only been documented by experimental work, investigating bending parameters such as bending radius, length, and distance of the bends. Even though damping mechanisms and causes are well-known, no simple, generally vali...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68568-0
更新日期：2020-07-17 00:00:00
abstract：:Pyrophosphate (PPi) is produced by anabolic reactions and serves as an energy donor in the cytosol of plant cells; however, its accumulation to toxic levels disrupts several common biosynthetic pathways and is lethal. Before acquiring photosynthetic capacity, young seedlings must endure a short but critical heterotrop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32894-1
更新日期：2018-10-02 00:00:00
abstract：:Neuropathic pain is characterized by an uncertain etiology and by a poor response to common therapies. The ineffectiveness and the frequent side effects of the drugs used to counteract neuropathic pain call for the discovery of new therapeutic strategies. Laser therapy proved to be effective for reducing pain sensitiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45469-5
更新日期：2019-06-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23237-1
更新日期：2018-04-24 00:00:00
abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01200
更新日期：2013-01-01 00:00:00
