Abstract：
:Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI). This study was performed to estimate the prognostic value of these factors in predicting survival and platinum resistance in ovarian cancer (OC), especially according to stage. Kaplan-Meier and multivariate analyses were performed to plot the survival curve and determine the independent prognostic factors. Additionally, the area under the receiver operating characteristic curve (AUC) was used to predict platinum resistance and prognosis by comparing the predictive ability of PNI and cancer antigen (CA)-125. In all patients, decreased PNI was significantly associated with platinum resistance and poor overall survival (OS) and progression-free survival (PFS). Regarding tumor stage, decreased PNI was significantly associated with poor PFS and OS only in stage III OC. Furthermore, the PNI also showed a significantly higher AUC value than CA-125 for predicting mortality and platinum resistance in all OC patients, but not in stage III patients. In conclusion, decreased PNI is a powerful predictor of a poor prognosis in OC, and especially for stage III cases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang W,Ye B,Liang W,Ren Ydoi
10.1038/s41598-017-10328-8subject
Has Abstractpub_date
2017-08-25 00:00:00pages
9548issue
1issn
2045-2322pii
10.1038/s41598-017-10328-8journal_volume
7pub_type
杂志文章abstract：:With the great development of sequencing technologies and systematic methods, our understanding of evolutionary relationships at deeper levels within the tree of life has greatly improved over the last decade. However, the current taxonomic methodology is insufficient to describe the growing levels of diversity in bot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28308
更新日期：2016-06-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-09-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22069-3
更新日期：2018-02-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/srep15796
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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