Abstract:
:Fruit ripening is a complex and genetically programmed process. Brassinosteroids (BRs) play an essential role in plant growth and development, including fruit ripening. As a central component of BR signaling, the transcription factor BZR1 is involved in fruit development in tomato. However, the transcriptional network through which BZR1 regulates fruit ripening is mostly unknown. In this study, we use isobaric tags for relative and absolute quantitation (iTRAQ) labeling technology to explore important proteins regulated by BZR1 in two independent tomato transgenic lines over-expressing BZR1-1D at four ripening stages, identifying 411 differentially expressed proteins. These proteins were implicated in light reaction, plant hormone pathways and cell-wall-related metabolism, etc. The 'light reaction' metabolic pathway was identified as a markedly enhanced pathway by BZR1 during tomato fruit ripening. The protein level of a probable 2-oxoglutarate-dependent dioxygenase 2-ODD2, involved in gibberellin biosynthesis was significantly increased at all four developmental and ripening stages. The results reveal molecular links between BR signaling pathway and downstream components involved in multiple ripening-associated events during tomato fruit ripening, which will provide new insights into the molecular mechanisms underlying tomato ripening regulatory networks, and be potential in understanding BR-regulated fruit ripening.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu L,Liu H,Li S,Zhang X,Zhang M,Zhu N,Dufresne CP,Chen S,Wang Qdoi
10.1038/srep33635subject
Has Abstractpub_date
2016-09-29 00:00:00pages
33635issn
2045-2322pii
srep33635journal_volume
6pub_type
杂志文章abstract::Transparent Er3+-doped germanotellurite glass ceramics (GCs) with variable Te/Ge ratio were prepared by controllable heat-treated process. X-ray diffraction (XRD) and transmission electron microscope (TEM) confirmed the formation of nanocrystals in glass matrix. Raman spectra were used to investigate the evolution of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43186
更新日期:2017-03-07 00:00:00
abstract::This study aimed to evaluate the effect of brain atrophy on the functional outcome of patients with moderate-volume basal ganglia hemorrhage. Of 1003 patients with spontaneous intracerebral hemorrhage, 124 with moderate-volume basal ganglia hemorrhage (hematoma volume of 20-50 mL) were enrolled. The intercaudate dista...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22916-3
更新日期:2018-03-19 00:00:00
abstract::This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79836-4
更新日期:2021-01-12 00:00:00
abstract::A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50320-y
更新日期:2019-10-01 00:00:00
abstract::There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38428-z
更新日期:2019-02-18 00:00:00
abstract::Ocular involvement in leukemia is considered rare. Ocular symptoms can be the presenting signs of leukemia, they can appear after diagnosis has been established, or they can be the first manifestation of a relapse after remission. We report, to the best of our knowledge for the first time, the ocular manifestation of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58654-8
更新日期:2020-02-06 00:00:00
abstract::Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role o...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-03573-4
更新日期:2017-06-16 00:00:00
abstract::Inflammatory processes have been implicated in the pathogenesis of Parkinson's disease (PD), including the development of PD-associated cognitive impairment. Whether genetic variants of inflammatory cytokine genes influence the risk of cognitive impairment in PD is unknown. In this study, we investigated single nucleo...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep19021
更新日期:2016-02-02 00:00:00
abstract::Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-langua...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-68082-3
更新日期:2020-07-06 00:00:00
abstract::To master linguistic communication, humans must acquire large vocabularies quickly and effortlessly. Efficient word learning might be facilitated by the ability to rapidly acquire novel word forms even outside the focus of attention, occurring within minutes of repetitive exposure and suggesting fast and automatic lex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34029-y
更新日期:2018-10-25 00:00:00
abstract::T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor involved in Th17 cell differentiation through direct transcriptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16355
更新日期:2015-11-09 00:00:00
abstract::To determine levels of change in risk factors for cardiovascular disease among people with and without a previous diagnosis of diabetes from 2007 to 2016 in Iran. Data were obtained from five rounds of the World Health Organization STEPwise approach to Surveillance (STEPS) cross-sectional surveys. Participants were 76...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-68640-9
更新日期:2020-07-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-35952-w
更新日期:2018-11-29 00:00:00
abstract::Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58126-z
更新日期:2020-03-12 00:00:00
abstract::SiO2 is the most significantly used insulator layer in semiconductor devices. Its functionality was recently extended to resistance switching random access memory, where the defective SiO2 played an active role as the resistance switching (RS) layer. In this report, the bias-polarity-dependent RS behaviours in the top...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22216
更新日期:2016-02-26 00:00:00
abstract::Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37425-6
更新日期:2019-01-30 00:00:00
abstract::Topoisomerases II (Top2s) are a group of essential enzymes involved in replication, transcription, chromosome condensation, and segregation via altering DNA topology. The mechanism of the Top2s poisons such as etoposide (VP-16) was reported as stabilizing the Top2-DNA complex and engendering permanent DNA breakage. As...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33366-2
更新日期:2018-10-08 00:00:00
abstract::Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Insecticide-susceptib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68121-z
更新日期:2020-07-07 00:00:00
abstract::To comprehensively assess whether p75ECD in urine could be a candidate biomarker for ALS evaluation. Urine samples were collected from 101 ALS patients, 108 patients with other neurological disease (OND) and 97 healthy controls. 61 ALS patients were followed up with clinical data including ALSFRS-r every 6 to 12 month...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05430-w
更新日期:2017-07-11 00:00:00
abstract::Renal fibrosis is one of the important pathways involved in end-stage renal failure. Investigating the metabolic changes in the progression of disease may enhance the understanding of its pathogenesis and therapeutic information. In this study, (1)H-nuclear magnetic resonance (NMR)-based metabonomics was firstly used ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27194
更新日期:2016-06-03 00:00:00
abstract::Recently, quantum Hall state analogs in classical mechanics attract much attention from topological points of view. Topology is not only for mathematicians but also quite useful in a quantum world. Further it even governs the Newton's law of motion. One of the advantages of classical systems over solid state materials...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18107
更新日期:2015-12-15 00:00:00
abstract::Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14122
更新日期:2015-09-21 00:00:00
abstract::Surface plasmon polaritons (SPPs) are propagating excitations that arise from coupling of light with collective electron oscillations. Characterized by high field intensity and nanometric dimensions, SPPs fashion rapid expansion of interest from fundamental and applicative perspectives. However, high metallic losses a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17562
更新日期:2015-12-01 00:00:00
abstract::The microbial community during fermented vegetable production has a large impact on the quality of the final products. Lactic acid bacteria have been well-studied in such processes, but knowledge about the roles of non-lactic acid bacteria is limited. This study aimed to provide useful knowledge about the relationship...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81105-x
更新日期:2021-01-19 00:00:00
abstract::Investigation of physician-related causes of unscheduled revisits to the emergency department (ED) within 72 h with subsequent admission to the intensive care unit (ICU) is an important parameter of emergency care quality. Between 2012 and 2017, medical records of all adult patients who visited the ED and returned wit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70021-1
更新日期:2020-08-03 00:00:00
abstract::Next generation sequencing is becoming the method of choice for functional genomic studies that use pooled shRNA or CRISPR libraries. A key challenge in sequencing these mixed-oligo libraries is that they are highly susceptible to hairpin and/or heteroduplex formation. This results in polyclonal, low quality, and inco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01170-z
更新日期:2017-04-21 00:00:00
abstract::Hypothermic oxygenated machine perfusion (HOPE) was recently tested in preclinical trials in kidney transplantation (KT). Here we investigate the effects of HOPE on extended-criteria-donation (ECD) kidney allografts (KA). Fifteen ECD-KA were submitted to 152 ± 92 min of end-ischemic HOPE and were compared to a matched...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74839-7
更新日期:2020-10-20 00:00:00
abstract::Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21282-4
更新日期:2018-02-16 00:00:00
abstract::Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine ap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48028-0
更新日期:2019-08-12 00:00:00
abstract::Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22643
更新日期:2016-03-04 00:00:00