Extraspinal findings prevalence and clinical significance in 4250 lumbar spine MRI exams.

Abstract:

:To assess extraspinal findings (ESFs) prevalence in lumbar spine MRI, including clinically significant findings using a systematic approach, and to determine their reporting rate. Lumbar spine MRI scans were retrospectively reviewed over 18 months by two radiologists. Reading discrepancies were resolved by consensus. ESFs were classified according to the involved system, clinical diagnosis, and clinical significance. The reporting rate was estimated by referring to the original report. There were 1509 ESFs in 1322/4250 patients with a substantial agreement between the two radiologists (kappa = 0.8). Almost half (621/1322) were in the 45-60 age group. Females represented 56.6% (748/1322). 74.2% (1120/1509) of the ESFs involved the urinary system among which 79.6% (892/1120) were renal cysts. Clinically significant findings represented 8.7% (131/1509) among which hydronephrosis represented 23% (30/131). First time detected malignant lesions represented 4.6% (6/131). ESFs reporting rate was 47.3%. 58.8% of the clinically significant ESFs were not reported. ESFs prevalence was 31.1%. The Urinary system was the most commonly involved. Most ESFs were benign warranting no further workup. However, clinically significant ESF were not infrequently detected. More than half of the clinically significant findings were not reported. A systematic review of MRI images is highly recommended to improve patient's outcome.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Khasawneh RA,Mohaidat Z,Khasawneh FA,Farah A,Gharaibeh M,El-Heis M

doi

10.1038/s41598-021-81069-y

subject

Has Abstract

pub_date

2021-01-13 00:00:00

pages

1190

issue

1

issn

2045-2322

pii

10.1038/s41598-021-81069-y

journal_volume

11

pub_type

杂志文章
  • Construction of a High-Density Genetic Map and Quantitative Trait Locus Mapping in the Sea Cucumber Apostichopus japonicus.

    abstract::Genetic linkage maps are critical and indispensable tools in a wide range of genetic and genomic research. With the advancement of genotyping-by-sequencing (GBS) methods, the construction of a high-density and high-resolution linkage maps has become achievable in marine organisms lacking sufficient genomic resources, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14852

    authors: Tian M,Li Y,Jing J,Mu C,Du H,Dou J,Mao J,Li X,Jiao W,Wang Y,Hu X,Wang S,Wang R,Bao Z

    更新日期:2015-10-06 00:00:00

  • Dynamics of the lung microbiome in intensive care patients with chronic obstructive pulmonary disease and community-acquired pneumonia.

    abstract::Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68100-4

    authors: Huang WC,Wu MF,Huang CC,Liu SY,Chen HC,Chen YY,Hsu JY,Huang CC

    更新日期:2020-07-06 00:00:00

  • Neural predictors of cognitive improvement by multi-strategic memory training based on metamemory in older adults with subjective memory complaints.

    abstract::Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such memory trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19390-2

    authors: Park S,Ryu SH,Yoo Y,Yang JJ,Kwon H,Youn JH,Lee JM,Cho SJ,Lee JY

    更新日期:2018-01-18 00:00:00

  • Enhanced high-frequency absorption of anisotropic Fe3O4/graphene nanocomposites.

    abstract::Anisotropic Fe3O4 nanoparticle and a series of its graphene composites have been successfully prepared as high-frequency absorbers. The crystal structure, morphology and magnetic property of the samples were detailed characterized through X-ray diffractometer (XRD), transmission electron microscopy (TEM) and vibrating...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25075

    authors: Yin Y,Zeng M,Liu J,Tang W,Dong H,Xia R,Yu R

    更新日期:2016-05-04 00:00:00

  • Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis.

    abstract::Toll-like receptor 7 (TLR7) mediates autoantigen and viral RNA-induced cytokine production. Increased TLR7 expression in human atherosclerotic lesions suggests its involvement in atherogenesis. Here we demonstrated TLR7 expression in macrophages, smooth muscle cells (SMCs), and endothelial cells from mouse atheroscler...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00977-0

    authors: Liu CL,Santos MM,Fernandes C,Liao M,Iamarene K,Zhang JY,Sukhova GK,Shi GP

    更新日期:2017-04-12 00:00:00

  • Interleukin-36β provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses.

    abstract::Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05363-4

    authors: Milora KA,Uppalapati SR,Sanmiguel JC,Zou W,Jensen LE

    更新日期:2017-07-19 00:00:00

  • Chimeric yellow fever 17D-Zika virus (ChimeriVax-Zika) as a live-attenuated Zika virus vaccine.

    abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31375-9

    authors: Giel-Moloney M,Goncalvez AP,Catalan J,Lecouturier V,Girerd-Chambaz Y,Diaz F,Maldonado-Arocho F,Gomila RC,Bernard MC,Oomen R,Delagrave S,Burdin N,Kleanthous H,Jackson N,Heinrichs J,Pugachev KV

    更新日期:2018-09-04 00:00:00

  • Effect of Water Compressibility, Sea-floor Elasticity, and Field Gravitational Potential on Tsunami Phase Speed.

    abstract::Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52475-0

    authors: Abdolali A,Kadri U,Kirby JT

    更新日期:2019-11-14 00:00:00

  • Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease.

    abstract::Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel-Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis in an organ- and cell-specific way. In this study, human liver samples were collected from hepatitis C-, alcoholic-, and cholestatic-associated fibrotic an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41038

    authors: Wang J,Lu Z,Xu Z,Tian P,Miao H,Pan S,Song R,Sun X,Zhao B,Wang D,Ma Y,Song X,Zhang S,Liu L,Jiang H

    更新日期:2017-01-23 00:00:00

  • Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration.

    abstract::Doxorubicin (Dox) is a highly effective anticancer drug but cause acute ventricular dysfunction, and also induce late-onset cardiomyopathy and heart failure. Despite extensive studies, the pathogenic sequelae leading to the progression of Dox-associated cardiomyopathy remains unknown. We assessed temporal changes in a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37862-3

    authors: Abdullah CS,Alam S,Aishwarya R,Miriyala S,Bhuiyan MAN,Panchatcharam M,Pattillo CB,Orr AW,Sadoshima J,Hill JA,Bhuiyan MS

    更新日期:2019-02-14 00:00:00

  • Structure and distribution of chalky deposits in the Pacific oyster using x-ray computed tomography (CT).

    abstract::Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68726-4

    authors: Banker RMW,Sumner DY

    更新日期:2020-07-21 00:00:00

  • Global-scale river flood vulnerability in the last 50 years.

    abstract::The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36021

    authors: Tanoue M,Hirabayashi Y,Ikeuchi H

    更新日期:2016-10-26 00:00:00

  • Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles.

    abstract::In recent years, active targeting strategies by ligand modification have emerged to enhance tumor accumulation of NP, but their clinical application was strictly restricted due to the complex preparation procedures, poor stability and serious toxicity. An effective and clinical translational strategy is required to sa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27669

    authors: Hu G,Cun X,Ruan S,Shi K,Wang Y,Kuang Q,Hu C,Xiao W,He Q,Gao H

    更新日期:2016-06-08 00:00:00

  • Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer.

    abstract::Oxidative stress and the formation of plaques which contain amyloid-β (Aβ) peptides are two key hallmarks of Alzheimer's disease (AD). Dityrosine is found in the plaques of AD patients and Aβ dimers have been linked to neurotoxicity. Here we investigate the formation of Aβ dityrosine dimers promoted by Cu2+/+ Fenton r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33935-5

    authors: Gu M,Bode DC,Viles JH

    更新日期:2018-11-01 00:00:00

  • Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).

    abstract::N-α-acetyltransferase 10 (Naa10) displays alpha (N-terminal) acetyltransferase activity. It functions as a major modulator of cell growth and differentiation. Until now, a few downstream targets were found, but no studies have concerned about which gene is the early event of Naa10 downstream target. As we know, the ea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38508

    authors: Xu H,Han Y,Liu B,Li R

    更新日期:2016-12-02 00:00:00

  • Video-rate volumetric neuronal imaging using 3D targeted illumination.

    abstract::Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temporal resolution. Widefield fluorescence microscopy can image large 2D fields of view at high resolution and speed while remaining simple and costeffective. A focal sweep add-on can further extend the capacity of widefie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26240-8

    authors: Xiao S,Tseng HA,Gritton H,Han X,Mertz J

    更新日期:2018-05-21 00:00:00

  • Honeybee pupal length assessed by CT-scan technique: effects of Varroa infestation, developmental stage and spatial position within the brood comb.

    abstract::Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46474-4

    authors: Facchini E,Nalon L,Andreis ME,Di Giancamillo M,Rizzi R,Mortarino M

    更新日期:2019-07-23 00:00:00

  • Study on Average Housing Prices in the Inland Capital Cities of China by Night-time Light Remote Sensing and Official Statistics Data.

    abstract::In this paper, the annually average Defense Meteorological Satellite Program-Operational Linescan System (DMSP/OLS) night-time light data is first proposed as a surrogate indicator to mine and forecast the average housing prices in the inland capital cities of China. First, based on the time-series analysis of individ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64506-2

    authors: Li C,Zhu H,Ye X,Jiang C,Dong J,Wang D,Wu Y

    更新日期:2020-05-07 00:00:00

  • P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency.

    abstract::To determine whether p16 INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1 -/-) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16 INK4a double-knockout, and Bmi-1 -/- and wild-type mice. Fifth-passage ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06868-8

    authors: Jin J,Tao J,Gu X,Yu Z,Wang R,Zuo G,Li Q,Lv X,Miao D

    更新日期:2017-08-08 00:00:00

  • Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene.

    abstract::Green fluorescent protein (GFP) is one of the most used reporter genes. We have used next-generation sequencing (NGS) to analyse the genetic diversity of a recombinant influenza A virus that expresses GFP and found a remarkable coverage dip in the GFP coding sequence. This coverage dip was present when virus-derived R...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26314

    authors: Van den Hoecke S,Verhelst J,Saelens X

    更新日期:2016-05-19 00:00:00

  • Chocolate for breakfast prevents circadian desynchrony in experimental models of jet-lag and shift-work.

    abstract::Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63227-w

    authors: Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RM

    更新日期:2020-04-10 00:00:00

  • An experimental study on the impacts of inspiratory and expiratory muscles activities during mechanical ventilation in ARDS animal model.

    abstract::In spite of intensive investigations, the role of spontaneous breathing (SB) activity in ARDS has not been well defined yet and little has been known about the different contribution of inspiratory or expiratory muscles activities during mechanical ventilation in patients with ARDS. In present study, oleic acid-induce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42785

    authors: Zhang X,Du J,Wu W,Zhu Y,Jiang Y,Chen R

    更新日期:2017-02-23 00:00:00

  • The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis.

    abstract::Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57192-2

    authors: Miyano K,Eto M,Hitomi S,Matsumoto T,Hasegawa S,Hirano A,Nagabuchi K,Asai N,Uzu M,Nonaka M,Omiya Y,Kaneko A,Ono K,Fujii H,Higami Y,Kono T,Uezono Y

    更新日期:2020-01-17 00:00:00

  • Three-dimensional structure analysis and percolation properties of a barrier marine coating.

    abstract::Artificially structured coatings are widely employed to minimize materials deterioration and corrosion, the annual direct cost of which is over 3% of the gross domestic product (GDP) for industrial countries. Manufacturing higher performance anticorrosive coatings is one of the most efficient approaches to reduce this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01177

    authors: Chen B,Guizar-Sicairos M,Xiong G,Shemilt L,Diaz A,Nutter J,Burdet N,Huo S,Mancuso J,Monteith A,Vergeer F,Burgess A,Robinson I

    更新日期:2013-01-01 00:00:00

  • Relationship between subjective sleep disturbances and glycaemia in Chinese adults with type 2 diabetes: findings from a 1.5-year follow-up study.

    abstract::We wanted to determine whether subjective sleep disturbance was associated with serum glycated hemoglobin (HbA1c) in people with type 2 diabetes mellitus. In total, 944 randomly-selected people with diabetes completed the Chinese version of the Pittsburgh Sleep Quality Index (PSQI). Participants' glycaemia was assesse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50814-9

    authors: Xu C,Zhang P,Xiang Q,Chang G,Zhang M,Zhang L,Li T,Qiao C,Qin Y,Lou P

    更新日期:2019-10-03 00:00:00

  • Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma.

    abstract::Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is now a widely-used modality for glioblastoma (GBM) treatment. However, intratumoral heterogeneity of fluorescence intensity may reflect different onco-metabolic programs. Here, we investigated the metabolic mechanism underlying the heterogeneity of 5-AL...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12557-3

    authors: Kim S,Kim JE,Kim YH,Hwang T,Kim SK,Xu WJ,Shin JY,Kim JI,Choi H,Kim HC,Cho HR,Choi A,Chowdhury T,Seo Y,Dho YS,Kim JW,Kim DG,Park SH,Kim H,Choi SH,Park S,Lee SH,Park CK

    更新日期:2017-09-22 00:00:00

  • Exotic superfluidity and pairing phenomena in atomic Fermi gases in mixed dimensions.

    abstract::Atomic Fermi gases have been an ideal platform for simulating conventional and engineering exotic physical systems owing to their multiple tunable control parameters. Here we investigate the effects of mixed dimensionality on the superfluid and pairing phenomena of a two-component ultracold atomic Fermi gas with a sho...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13321-3

    authors: Zhang L,Che Y,Wang J,Chen Q

    更新日期:2017-10-11 00:00:00

  • Genetic dissection of host immune response in pneumonia development and progression.

    abstract::The role of host genetic variation in pneumonia development and outcome is poorly understood. We studied common polymorphisms in the genes of proinflammatory cytokines (IL6 rs1800795, IL8 rs4073, IL1B rs16944), anti-inflammatory cytokines (IL10 rs1800896, IL4 rs2243250, IL13 rs20541) and toll-like receptors (TLR2 rs57...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep35021

    authors: Smelaya TV,Belopolskaya OB,Smirnova SV,Kuzovlev AN,Moroz VV,Golubev AM,Pabalan NA,Salnikova LE

    更新日期:2016-10-11 00:00:00

  • Health-related quality of life amongst people diagnosed with abdominal aortic aneurysm and peripheral artery disease and the effect of fenofibrate.

    abstract::The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate impro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71454-4

    authors: Golledge J,Pinchbeck J,Rowbotham SE,Yip L,Jenkins JS,Quigley F,Moxon JV

    更新日期:2020-09-03 00:00:00

  • Elevated plasma abscisic acid is associated with asymptomatic falciparum malaria and with IgG-/caspase-1-dependent immunity in Plasmodium yoelii-infected mice.

    abstract::Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27073-1

    authors: Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

    更新日期:2018-06-11 00:00:00