Abstract：
:Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes in microbial airway composition and its variations between COPD patients with different weaning outcomes. Fifty-one endotracheal aspirate samples from 21 participants and 5 saline samples were collected as the patient and control group, respectively. Sequence analysis revealed significant increases and upward trends in the relative abundance of the Acinetobacter genus and Acinetobacter baumannii complex species in paired comparisons of sampling points and over time, respectively, in patients with failed weaning (p for trend = 0.012 and 0.012, respectively) but not in those with successful weaning (p for trend = 0.335 and 0.426, respectively). Furthermore, significant changes in the composition of the bacterial community were observed in paired comparisons of sampling points in patients with failed weaning compared with those with successful weaning. The alpha diversity did not differ between the patients with different weaning outcomes. These results further the understanding of longitudinal airway microbiome structure analysis and its clinical implications when managing critically ill patients with and without COPD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huang WC,Wu MF,Huang CC,Liu SY,Chen HC,Chen YY,Hsu JY,Huang CCdoi
10.1038/s41598-020-68100-4subject
Has Abstractpub_date
2020-07-06 00:00:00pages
11046issue
1issn
2045-2322pii
10.1038/s41598-020-68100-4journal_volume
10pub_type
杂志文章abstract：:Synthesis of homogenous glycans in quantitative yields represents a major bottleneck to the production of molecular tools for glycoscience, such as glycan microarrays, affinity resins, and reference standards. Here, we describe a combined biological/enzymatic synthesis that is capable of efficiently converting microbi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15891-8
更新日期：2017-11-21 00:00:00
abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-56530-8
更新日期：2020-01-23 00:00:00
abstract：:Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51095-y
更新日期：2019-10-11 00:00:00
abstract：:Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22643
更新日期：2016-03-04 00:00:00
abstract：:Treatment of decompensated heart failure often includes administration of levosimendan. Myeloperoxidase (MPO) is released during polymorphonuclear neutrophil (PMN) degranulation, and mediates dysregulation of vascular tone in heart failure. We evaluated the effects of levosimendan-treatment on MPO in patients with acu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09704
更新日期：2015-04-13 00:00:00
abstract：:Animal behavior is highly structured. Yet, structured behavioral patterns-or "statistical ethograms"-are not immediately apparent from the full spatiotemporal data that behavioral scientists usually collect. Here, we introduce a framework to quantitatively characterize rodent behavior during spatial (e.g., maze) navig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79744-7
更新日期：2021-01-11 00:00:00
abstract：:High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68319-1
更新日期：2020-07-10 00:00:00
abstract：:The recent reaching of 20% of conversion efficiency by solar cells based on metal hybrid perovskites (MHP), e.g., the methylammonium (MA) lead iodide, CH3NH3PbI3 (MAPbI3), has excited the scientific community devoted to the photovoltaic materials. However, the toxicity of Pb is a hindrance for large scale commercial o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47192-7
更新日期：2019-07-30 00:00:00
abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23009
更新日期：2016-03-11 00:00:00
abstract：:Vitamin D deficiency has been related with metabolic alterations in polycystic ovary syndrome (PCOS). As well, hyperactivation of adrenal axis can be programmed early in life and could be related later with PCOS development. Our aim was to establish the relationship between vitamin D and adrenal parameters with metabo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40653-z
更新日期：2019-03-08 00:00:00
abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05518
更新日期：2014-07-01 00:00:00
abstract：:Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle tracking, mean-squared displacement (MSD), turning angle, ergodic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30384-y
更新日期：2018-08-10 00:00:00
abstract：:Nonstructural protein 1 (NS1) is secreted by dengue virus in the first days of infection and acts as an excellent dengue biomarker. Here, the direct electrical detection of NS1 from dengue type 2 virus has been achieved by the measurement of variations in open circuit potential (OCP) between a reference electrode and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07865
更新日期：2015-01-19 00:00:00
abstract：:It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29588
更新日期：2016-07-12 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54657-2
更新日期：2019-11-25 00:00:00
abstract：:Attending a location in space facilitates responses to targets at that location when the time between cue and target is short. Certain types of exogenous cues - such as sudden peripheral onsets - have been described as reflexive and automatic. Recent studies however, have been showing many cases where exogenous cues a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31633-w
更新日期：2018-09-05 00:00:00
abstract：:Recent increases in family planning (FP) use have been reported among women of reproductive age in union (WRAU) in Senegal. However, trends have not been monitored among harder-to-reach groups (including adolescents, unmarried and rural poor women), key to understanding whether FP progress is equitable. We combined da...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41006
更新日期：2017-01-20 00:00:00
abstract：:Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by the SFTS phlebovirus (SFTSV). SFTS patients were first reported in China, followed by Japan and South Korea. In 2017, cats were diagnosed with SFTS for the first time, suggesting that these animals are susceptible to SFTSV. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48317-8
更新日期：2019-08-19 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-35437-w
更新日期：2018-11-22 00:00:00
abstract：:Skin malignant melanoma is a highly angiogenic cancer, necessitating early diagnosis for positive prognosis. The current diagnostic standard of biopsy and histological examination inevitably leads to many unnecessary invasive excisions. Here, we propose a non-invasive method of identification of melanoma based on bloo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12825
更新日期：2015-08-11 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47506-9
更新日期：2019-08-21 00:00:00
abstract：:Triple-doped (Yb(3+)/Er(3+)/Tm(3+)) KMnF3 nanocubes with uniform sizes of 250 nm were synthesized by a facile hydrothermal route using the oleic acid as the capping agent. It was found that these nanocubes can simultaneously exhibited four-color (blue, green, red and NIR) upconversion emissions under a single 980 nm n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17088
更新日期：2015-11-26 00:00:00
abstract：:Superconductivity within layered crystal structures has attracted sustained interest among condensed matter community, primarily due to their exotic superconducting properties. EuBiS2F is a newly discovered member in the BiS2-based superconducting family, which shows superconductivity at 0.3 K without extrinsic doping...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37394
更新日期：2016-11-22 00:00:00
abstract：:Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28575-8
更新日期：2018-07-06 00:00:00
abstract：:Chaetosiphella stipae stipae is a xerothermophilous aphid, associated with Palaearctic temperate steppe zones or dry mountain valleys, where there are grasses from the genus Stipa. Its geographical distribution shows several populations that are spread from Spain, across Europe and Asia Minor, to Mongolia and China. G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43988
更新日期：2017-03-08 00:00:00
abstract：:For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39221
更新日期：2016-12-15 00:00:00
abstract：:A new approach for achieving two - dimensional (2D) atom localization microscopy based on the projection of three - dimensional (3D) localization in the plane of the detector is described in the present work. Spatial variation of the position-dependent 2D-localization pattern in the xy-plane is obtained with the shift...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57141-z
更新日期：2020-01-17 00:00:00
abstract：:The Disc Agarose Channel (DAC) system utilizes microfluidics and imaging technologies and is fully automated and capable of tracking single cell growth to produce Mycobacterium tuberculosis (MTB) drug susceptibility testing (DST) results within 3~7 days. In particular, this system can be easily used to perform DSTs wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26419-z
更新日期：2018-06-05 00:00:00
abstract：:Adaptation of visual responses enhances visual information processing mainly by preserving the full dynamic range of neuronal responses during changing light conditions and is found throughout the whole visual system. Although adaptation in the primate superior colliculus neurons has received much attention little is ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27331-2
更新日期：2018-06-12 00:00:00
abstract：:The 37 currently recognized Bemisia tabaci cryptic species are economically important species and contain both primary and secondary endosymbionts, but their diversity has never been mapped systematically across the group. To achieve this, PacBio sequencing of full-length bacterial 16S rRNA gene amplicons was carried ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42793-8
更新日期：2019-04-25 00:00:00
