Abstract:
:High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced vasodilation (NID), brachial intima media thickness (IMT), and brachial-ankle pulse wave velocity (baPWV) in 807 men. The subjects were divided into six groups according to the levels of Hct, Hb and RBCs. NID was highest in the 46.0-48.9% Hct group among the six groups according to Hct levels. Brachial IMT was lowest in the 46.0-48.9% Hct group among the six groups. There were no significant differences in FMD and baPWV among the six groups. We used 46.0-48.9% Hct as a reference to define the lower tertile. The adjusted odds ratio of being in the low tertile of NID was significantly higher in the < 42.9% and ≥ 49.0% Hct groups. Adjusted odds ratio of being in the low tertile of brachial IMT was significantly lower in the < 39.9% Hct groups. Similar results were obtained for Hb and RBCs. Low and high levels of Hct, Hb and RBCs were associated with vascular smooth muscle dysfunction, and low Hct levels were associated with abnormal vascular structure. Increases in the levels of Hct, Hb and RBCs within normal ranges may have beneficial effects on the vasculature.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kishimoto S,Maruhashi T,Kajikawa M,Matsui S,Hashimoto H,Takaeko Y,Harada T,Yamaji T,Han Y,Kihara Y,Chayama K,Goto C,Yusoff FM,Nakashima A,Higashi Ydoi
10.1038/s41598-020-68319-1subject
Has Abstractpub_date
2020-07-10 00:00:00pages
11467issue
1issn
2045-2322pii
10.1038/s41598-020-68319-1journal_volume
10pub_type
杂志文章abstract::Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 healthy controls and constructed a functional lncRNA-mRNA co-expression network. We revealed two distinctive co-e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32731
更新日期:2016-09-06 00:00:00
abstract::In this study, we have employed graphene oxide as a matrix to simultaneously and directly quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted laser/desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS). Twelve serum nonesterified FAs combined...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34201
更新日期:2016-09-30 00:00:00
abstract::Identifying communities in complex networks is an effective means for analyzing complex systems, with applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of nodes and finding communities of links are two popular schemes for network analysis. These schemes, howev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08638
更新日期:2015-03-02 00:00:00
abstract::Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63533-3
更新日期:2020-04-14 00:00:00
abstract::Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36248
更新日期:2016-10-26 00:00:00
abstract::Mulching with organic materials is a management practice with long history for weed suppression, soil water conservation and erosion control. Its potential impact on crop pests is less well explored. Here we report its utility for reducing crop damage by the serious pest, sweetpotato weevil (Cylas formicarius). Labora...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50521-5
更新日期:2019-10-16 00:00:00
abstract::The rise of antibiotic resistance (AMR) is one of the most important public health threats worldwide.Today, increasing attention is being paid to multidrug resistant staphylococci isolated from healthcare and non-healthcare environments as the treatment of these bacteria has become increasingly difficult. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45886-6
更新日期:2019-08-01 00:00:00
abstract::Ion pumps and channels are responsible for a wide variety of biological functions. Ion pumps transport only one ion during each stimulus-dependent reaction cycle, whereas ion channels conduct a large number of ions during each cycle. Ion pumping rhodopsins such as archaerhodopsin-3 (Arch) are often utilized as light-d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44308-x
更新日期:2019-05-27 00:00:00
abstract::This study aimed to investigate the basilar artery (BA) geometric changes in a longitudinal study. 154 subjects with normal vertebrobasilar arterial systems on magnetic resonance angiography were assigned into two groups: 1) non-dominant vertebral artery (VA) and 2) VA dominance. We defined the dominant VA as either t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65682-x
更新日期:2020-06-01 00:00:00
abstract::Breaking Continuous Flash Suppression (bCFS) has been adopted as an appealing means to study human visual awareness, but the literature is beclouded by inconsistent and contradictory results. Although previous reviews have focused chiefly on design pitfalls and instances of false reasoning, we show in this study that ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03396-3
更新日期:2017-06-07 00:00:00
abstract::Thaumarchaeota and the gene encoding for a subunit of ammonia monooxygenase (amoA) are ubiquitous in Polar Seas, and some Thaumarchaeota also have a gene coding for ureC, diagnostic for urease. Using quantitative PCR we investigated the occurrence of genes and transcripts of ureC and amoA in Arctic samples from winter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04661
更新日期:2014-04-11 00:00:00
abstract::Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32725-3
更新日期:2018-09-28 00:00:00
abstract::The human cytomegalovirus developed distinct evasion mechanisms from the cellular antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellular apoptosis but also to inhibit signalling downstream from mitochondrial MAVS. vMIA has been shown to localize at mitochondria and to tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26028
更新日期:2016-05-16 00:00:00
abstract::Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14675
更新日期:2015-09-30 00:00:00
abstract::Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29474-8
更新日期:2018-07-23 00:00:00
abstract::Gaucher disease (GD) is a rare inherited metabolic disease caused by pathogenic variants in the GBA1 gene. So far, the pathomechanism of GD was investigated mainly in animal models. In order to delineate the molecular changes in GD cells we analysed gene expression profile in cultured skin fibroblasts from GD patients...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42584-1
更新日期:2019-04-15 00:00:00
abstract::Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46318-1
更新日期:2019-07-08 00:00:00
abstract::The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic myelogenous leukemia (CML), CCL3 is critical for the maintenance of a leukemia stem cell population, and leukemia progression. With CCL3 implicated as a potentially via...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32978-y
更新日期:2018-10-02 00:00:00
abstract::Bovine milk is vital for infant nutrition and is a major component of the human diet. Bovine mastitis is a common inflammatory disease of mammary gland in cattle. It alters the immune profile of the animal and lowers the quality and yield of milk causing huge economic losses to dairy industry. The incidence of sub-cli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66211-6
更新日期:2020-06-09 00:00:00
abstract::Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05360-7
更新日期:2017-07-10 00:00:00
abstract::Pandanus odorifer (Forssk) Kuntze grows naturally along the coastal regions and withstands salt-sprays as well as strong winds. A combination of omics approaches and enzyme activity studies was employed to comprehend the mechanistic basis of high salinity tolerance in P. odorifer. The young seedlings of P. odorifer we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37039-y
更新日期:2019-01-30 00:00:00
abstract::Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer cell invasion and metastatic potential. However, the underlying mechanisms of how it is implica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37425-6
更新日期:2019-01-30 00:00:00
abstract::Little is known about the combined effects of stressors on social immunity of honey bees (Apis mellifera) and related gene expression. The interaction between sublethal doses of a neurotoxin, clothianidin, and the ectoparasite, Varroa destructor, was examined by measuring differentially expressed genes (DEGs) in brain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41365-0
更新日期:2019-03-26 00:00:00
abstract::We present a method by which the spectral intensity of an ultrafast laser pulse can be accumulated at selected frequencies by a controllable amount. Using a 4-f pulse shaper we modulate the phase of the frequency components of a femtosecond laser. By inducing femtosecond filamentation with the modulated pulse, we can ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43367
更新日期:2017-03-07 00:00:00
abstract::Feedback information is essential for us to adapt appropriately to the environment. The feedback-related negativity (FRN), a frontocentral negative deflection after the delivery of feedback, has been found to be larger for outcomes that are worse than expected, and it reflects a reward prediction error derived from th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34032
更新日期:2016-10-03 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-37133-1
更新日期:2018-12-14 00:00:00
abstract::Aquaculture is a burgeoning industry, requiring diversification into new farmed species, which are often at risk from infectious disease. We used a mesocosm technique to investigate the susceptibility of sharpsnout seabream (Diplodus puntazzo) larvae to potential environmental pathogens in seawater compared to control...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17609
更新日期:2015-12-07 00:00:00
abstract::The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression and its mechanism. The mechanical stretch downregulated SO2/AAT1 pathway and increased collagen I and III protein expression. Importantly, AA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21112
更新日期:2016-02-16 00:00:00
abstract::Balancing stomata-dependent CO2 assimilation and transpiration is a key challenge for increasing crop productivity and water use efficiency under drought stress for sustainable crop production worldwide. Here, we show that cucumber and luffa plants with luffa as rootstock have intrinsically increased water use efficie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20212
更新日期:2016-02-02 00:00:00
abstract::Until now, the only kind of practical quantum private query (QPQ), quantum-key-distribution (QKD)-based QPQ, focuses on the retrieval of a single bit. In fact, meaningful message is generally composed of multiple adjacent bits (i.e., a multi-bit block). To obtain a message a1a2···al from database, the user Alice has t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07537
更新日期:2014-12-18 00:00:00