Abstract:
:In this study, we have employed graphene oxide as a matrix to simultaneously and directly quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted laser/desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS). Twelve serum nonesterified FAs combined with their individual esterified FAs (i.e., C16:0, C16:1, C18:0, C18:1, C18:2, C18:3, C20:2, C20:3, C20:4, C20:5, C22:5, and C22:6) were quantified based on their calibration curves with the correlation coefficients of >0.99, along with the analytical time of <1 min each sample. As a result, serum levels of twelve total FAs (TFAs) in 1440 serum samples from 487 healthy controls (HCs), 479 patients with benign lung diseases (BLDs) and 474 patients with lung cancer (LC) were determined. Statistical analysis indicated that significantly increased levels of C16:0, C16:1, C18:0, C18:1, C18:3, C20:3, and C22:6 and decreased levels of C20:5 were observed in LC patients compared with BLDs. Receiver operating characteristic (ROC) analysis revealed that panel a (C18:2, C20:3, C20:4, C20:5, C22:5, and C22:6), panel b (C18:0, C20:4, C20:5, and C22:6), and panel c (C16:1, C18:0, C18:1, C20:3, and C22:6) have exhibited good diagnostic ability to differentiate BLDs from LC relative to clinical uses of tumor markers (CEA and Cyfra 21-1).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ren J,Zhang D,Liu Y,Zhang R,Fang H,Guo S,Zhou D,Zhang M,Xu Y,Qiu L,Li Zdoi
10.1038/srep34201subject
Has Abstractpub_date
2016-09-30 00:00:00pages
34201issn
2045-2322pii
srep34201journal_volume
6pub_type
杂志文章abstract::At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analogue of anandamide, a widely studied endocannabinoid derived from arachid...
journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2021-01-12 00:00:00
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journal_title:Scientific reports
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-01-21 00:00:00
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pub_type: 杂志文章
doi:10.1038/srep29880
更新日期:2016-07-19 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-13 00:00:00
abstract::This paper reports on 3D phase field simulations of IMC growth in Co/Sn and Cu/Sn solder systems. In agreement with experimental micrographs, we obtain uniform growth of the CoSn3 phase in Co/Sn solder joints and a non-uniform wavy morphology for the Cu6Sn5 phase in Cu/Sn solder joints. Furthermore, simulations were p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51179-9
更新日期:2019-10-16 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32993
更新日期:2016-09-12 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70954-7
更新日期:2020-08-18 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45126
更新日期:2017-03-27 00:00:00
abstract::Three dimensional (3D) co-cultures to mimic cellular dynamics have brought significant impacts in tissue engineering approaches for biomedical research. Herein, we present a novel sample holder combined with time-lapse fluorescence imaging technique, referred as 4D live cell imaging, allowing direct visualization of v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28206-2
更新日期:2018-06-29 00:00:00
abstract::At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-41619-x
更新日期:2019-03-25 00:00:00
abstract::Unlike the constant nature of elastic coefficients of isotropic bulk materials, the Young's (E) and shear (μ) moduli of nano-structured (NS) gyroid metamaterials change with relative density (ρ), but at different rates depending on the cell size of the structure. These elastic behaviors displayed by E and μ cause cros...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10978-8
更新日期:2017-09-05 00:00:00
abstract::Dirt and microorganisms are the major problems in textiles which can generate unpleasant odor during their growth. Here, zinc oxide (ZnO) nanoparticles prepared by sol-gel method were loaded on the cotton fabrics using spin coating technique to enhance their antimicrobial properties and water repellency. The effects o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22324-7
更新日期:2018-03-02 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39443
更新日期:2016-12-19 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28448-0
更新日期:2018-07-04 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10521
更新日期:2015-05-21 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63598-0
更新日期:2020-04-20 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49946-9
更新日期:2019-09-16 00:00:00
abstract::Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice rece...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43035
更新日期:2017-02-21 00:00:00
abstract::Although it is well known that mean annual rainfall (MAR) and rainfall seasonality have a key role in influencing the distribution of tree and grass cover in African tropical grassy biomes (TGBs), the impact of intra-seasonal rainfall variability on these distributions is less agreed upon. Since the prevalent mechanis...
journal_title:Scientific reports
pub_type: 杂志文章
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更新日期:2019-02-20 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21753-8
更新日期:2018-02-23 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16235-2
更新日期:2017-11-22 00:00:00
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journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44855-3
更新日期:2019-06-18 00:00:00
abstract::We study the dynamics of an ultrafast single photon pulse in a one-dimensional waveguide two-point coupled with a Jaynes-Cummings system. We find that for any single photon input the transmissivity depends periodically on the separation between the two coupling points. For a pulse containing many plane wave components...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33867
更新日期:2016-09-22 00:00:00