Systematic identification and characterization of Aedes aegypti long noncoding RNAs (lncRNAs).

Abstract:

:Long noncoding RNAs (lncRNAs) play diverse roles in biological processes. Aedes aegypti (Ae. aegypti), a blood-sucking mosquito, is the principal vector responsible for replication and transmission of arboviruses including dengue, Zika, and Chikungunya virus. Systematic identification and developmental characterisation of Ae. aegypti lncRNAs are still limited. We performed genome-wide identification of lncRNAs, followed by developmental profiling of lncRNA in Ae. aegypti. We identified a total of 4,689 novel lncRNA transcripts, of which 2,064, 2,076, and 549 were intergenic, intronic, and antisense respectively. Ae. aegypti lncRNAs share many characteristics with other species including low expression, low GC content, short in length, and low conservation. Besides, the expression of Ae. aegypti lncRNAs tend to be correlated with neighbouring and antisense protein-coding genes. A subset of lncRNAs shows evidence of maternal inheritance; hence, suggesting potential role of lncRNAs in early-stage embryos. Additionally, lncRNAs show higher tendency to be expressed in developmental and temporal specific manner. The results from this study provide foundation for future investigation on the function of Ae. aegypti lncRNAs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Azlan A,Obeidat SM,Yunus MA,Azzam G

doi

10.1038/s41598-019-47506-9

subject

Has Abstract

pub_date

2019-08-21 00:00:00

pages

12147

issue

1

issn

2045-2322

pii

10.1038/s41598-019-47506-9

journal_volume

9

pub_type

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