P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency.

abstract：:More and more researchers are interested in and focused on how a limited repertoire of antibodies can bind and correspondingly protect against an almost limitless diversity of invading antigens. In this work, a series of 200-ns molecular dynamics (MD) simulations followed by principal component (PC) analysis and free ...

journal_title：Scientific reports

authors： Chen J,Wang J,Zhu W

更新日期：2016-11-10 00:00:00

abstract：:Al substitution in hematite is ubiquitous in soils. With the increase of Al amount, the hematite morphology changes from rhombohedral crystals to disk-shaped ones, but the underlying mechanism is poorly understood. Herein, a series of Al-substituted hematite were synthesized and characterized by synchrotron X-ray diff...

journal_title：Scientific reports

authors： Li W,Liang X,An P,Feng X,Tan W,Qiu G,Yin H,Liu F

更新日期：2016-10-27 00:00:00

abstract：:Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...

journal_title：Scientific reports

authors： Sgambato C,Faure Walker JP,Mildon ZK,Roberts GP

更新日期：2020-07-29 00:00:00

abstract：:Prospective observation of hemodynamic changes before and after the formation of atherosclerotic stenosis in the carotid artery is difficult. Thus, a vessel surface repairing method was used for retrospective hemodynamic study before and after atherosclerotic stenosis formation in carotid artery. The three-dimensional...

journal_title：Scientific reports

authors： Li X,Sun B,Zhao H,Ge X,Liang F,Li X,Xu J,Liu X

更新日期：2018-04-03 00:00:00

abstract：:Mucosal melanomas are primary malignant neoplasias originated from melanocytes within mucous membranes in any part of mucosal surface lining, more commonly, in the nasal cavity and accessory sinuses, oral cavity, lips, pharynx, vulvar, vaginal, cervix and anorectal mucosa. Epidemiology data regarding mucosal melanomas...

journal_title：Scientific reports

authors： Cohen Goldemberg D,de Melo AC,de Melo Pino LC,Thuler LCS

更新日期：2020-01-16 00:00:00

abstract：:Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we eval...

journal_title：Scientific reports

authors： Wang Q,Wang M,Lu X,Wang K,Fang L,Ren F,Lu G

更新日期：2017-11-09 00:00:00

abstract：:Aluminium alloys are re-evaluated as most feasible way to satisfy the industrial needs of light-weight structural materials. However, unlike conventional structural metals such as iron and titanium, aluminium does not have easily accessible secondary phases, which means that aluminium-based alloys cannot be strengthen...

journal_title：Scientific reports

authors： Tsuru T,Shimizu K,Yamaguchi M,Itakura M,Ebihara K,Bendo A,Matsuda K,Toda H

更新日期：2020-04-06 00:00:00

abstract：:Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...

journal_title：Scientific reports

authors： Fu J,He C,Xia B,Li Y,Feng Q,Yin Q,Shi X,Feng X,Wang H,Yao H

更新日期：2016-03-22 00:00:00

abstract：:Decreasing egg quality following oocyte ageing is a major restricting factor for the breeding programs. The mechanisms behind this process has not yet been clarified. To examine the possible involvement of oxidative stress in the oocyte ageing process, the relative mRNA abundance of specific transcripts were determine...

journal_title：Scientific reports

authors： Samarin AM,Samarin AM,Østbye TK,Ruyter B,Sampels S,Burkina V,Blecha M,Policar T

更新日期：2019-07-18 00:00:00

abstract：:Moisture in materials can be a source of future outgassing and exacerbate unwanted changes in physical and chemical properties. Here, we investigate the effect of sample size and shape on the moisture transport phenomena through a combined experimental and modeling approach. Several different materials varying in size...

journal_title：Scientific reports

authors： Sharma HN,Sun Y,Glascoe EA

更新日期：2020-10-20 00:00:00

abstract：:The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the fina...

journal_title：Scientific reports

authors： Yu G,Li L,Liu X,Liu G,Deng Z,Zabriskie MT,Jiang M,He X

更新日期：2015-12-01 00:00:00

abstract：:Malaria is among the major threats to global health with the main burden of disease being in rural areas of developing countries where accurate diagnosis based on non-invasive samples is in high demand. We here present a novel molecular assay for detection of malaria parasites based on technology that may be adapted f...

journal_title：Scientific reports

authors： Hede MS,Fjelstrup S,Lötsch F,Zoleko RM,Klicpera A,Groger M,Mischlinger J,Endame L,Veletzky L,Neher R,Simonsen AKW,Petersen E,Mombo-Ngoma G,Stougaard M,Ho YP,Labouriau R,Ramharter M,Knudsen BR

更新日期：2018-03-07 00:00:00

abstract：:The role of the different lymphocyte populations in liver microenvironment of chronic hepatitis C (CHC) patients is still matter of debate. Since Th17 and Treg have opposite functions, their balance could affect disease progression. The aim was to explore liver microenvironment and its peripheral blood counterpart in ...

journal_title：Scientific reports

authors： Rios DA,Valva P,Casciato PC,Frias S,Soledad Caldirola M,Gaillard MI,Bezrodnik L,Bandi J,Galdame O,Ameigeiras B,Krasniansky D,Brodersen C,Mullen E,Matteo EN,Preciado MV

更新日期：2017-10-16 00:00:00

abstract：:To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide associatio...

journal_title：Scientific reports

authors： Takahashi H,Cornish AJ,Sud A,Law PJ,Kinnersley B,Ostrom QT,Labreche K,Eckel-Passow JE,Armstrong GN,Claus EB,Il'yasova D,Schildkraut J,Barnholtz-Sloan JS,Olson SH,Bernstein JL,Lai RK,Schoemaker MJ,Simon M,Hoffmann P,

更新日期：2018-02-05 00:00:00

abstract：:The morphology of hexagonal phase NaYF4:Er(3+) nanorods synthesized by hydrothermal method changed greatly after a continuing calcination, along with a phase transformation to cubic phase. Photoluminescence (PL) spectra indicated that mid-infrared (MIR) emission was obtained in both hexagonal and cubic phase NaYF4:Er(...

journal_title：Scientific reports

authors： Yang D,Chen D,He H,Pan Q,Xiao Q,Qiu J,Dong G

更新日期：2016-07-25 00:00:00

abstract：:New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vacc...

journal_title：Scientific reports

authors： Champredon D,Laskowski M,Charland N,Moghadas SM

更新日期：2018-04-24 00:00:00

abstract：:Plumbagin, an anti-cancer agent, is toxic to cells of multiple species. We investigated if plumbagin targets conserved biochemical processes. Plumbagin induced DNA damage and apoptosis in cells of diverse mutational background with comparable potency. A 3-5 fold increase in intracellular oxygen radicals occurred in re...

journal_title：Scientific reports

authors： Kapur A,Beres T,Rathi K,Nayak AP,Czarnecki A,Felder M,Gillette A,Ericksen SS,Sampene E,Skala MC,Barroilhet L,Patankar MS

更新日期：2018-01-18 00:00:00

abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...

journal_title：Scientific reports

authors： Bhowal A,Majumder S,Ghosh S,Basu S,Sen D,Roychowdhury S,Sengupta S,Chatterji U

更新日期：2017-08-29 00:00:00

abstract：:Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to date. In this study, we observed that the mRNA and protein levels of Exo70 were ...

journal_title：Scientific reports

authors： Xiao L,Zheng K,Lv X,Hou J,Xu L,Zhao Y,Song F,Fan Y,Cao H,Zhang W,Hong X,Zhan YY,Hu T

更新日期：2017-07-11 00:00:00

abstract：:Air-core magnetometers are amongst the most commonly used magnetic field detectors in biomedical instruments. They offer excellent sensitivity, low fabrication complexity and a robust, cost-effective solution. However, air-core magnetometers must be tailored to the specific application to achieve high sensitivity, whi...

journal_title：Scientific reports

authors： Pellicer-Guridi R,Vogel MW,Reutens DC,Vegh V

更新日期：2017-05-23 00:00:00

abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...

journal_title：Scientific reports

authors： Zou Y,Wang S

更新日期：2015-07-07 00:00:00

abstract：:Dissection of the neural circuits of the cerebral cortex is essential for studying mechanisms underlying brain function. Herein, combining a retrograde rabies tracing system with fluorescent micro-optical sectional tomography, we investigated long-range input neurons of corticotropin-releasing hormone containing neuro...

journal_title：Scientific reports

authors： Zhao P,Zhao M,Wang H,Jiang T,Jia X,Tian J,Li A,Gong H,Li X

更新日期：2020-07-22 00:00:00

abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

journal_title：Scientific reports

authors： Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

更新日期：2020-04-03 00:00:00

abstract：:The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but misclassification has been common due to similarities in their rDNA sequences and phenotypes. To better understand their evolutionary relationshi...

journal_title：Scientific reports

authors： Ke HM,Prachumwat A,Yu CP,Yang YT,Promsri S,Liu KF,Lo CF,Lu MJ,Lai MC,Tsai IJ,Li WH

更新日期：2017-02-01 00:00:00

abstract：:Protocadherin 19 (Pcdh19) is an X-linked gene belonging to the protocadherin superfamily, whose members are predominantly expressed in the central nervous system and have been implicated in cell-cell adhesion, axon guidance and dendrite self-avoidance. Heterozygous loss-of-function mutations in humans result in the ch...

journal_title：Scientific reports

authors： Pederick DT,Homan CC,Jaehne EJ,Piltz SG,Haines BP,Baune BT,Jolly LA,Hughes JN,Gecz J,Thomas PQ

更新日期：2016-05-31 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...

journal_title：Scientific reports

authors： You Y,Ramachandra SG,Jin T

更新日期：2020-09-08 00:00:00

abstract：:Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, ...

journal_title：Scientific reports

authors： Ujfaludi Z,Tuzesi A,Majoros H,Rothler B,Pankotai T,Boros IM

更新日期：2018-02-08 00:00:00

abstract：:Biofertilizer production and application for sustainable agriculture is already a reality. The methods for biofertilizers delivery in crop fields are diverse. Although foliar spray is gaining wide acceptance, little is known about the influence that the biochemical features of leaves have on the microbial colonization...

journal_title：Scientific reports

authors： Ramírez-Ordorica A,Valencia-Cantero E,Flores-Cortez I,Carrillo-Rayas MT,Elizarraraz-Anaya MIC,Montero-Vargas J,Winkler R,Macías-Rodríguez L

更新日期：2020-05-21 00:00:00

abstract：:There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subje...

journal_title：Scientific reports

authors： Chu X,Zhou Y,Hu Z,Lou J,Song W,Li J,Liang X,Chen C,Wang S,Yang B,Chen L,Zhang X,Song J,Dong Y,Chen S,He L,Xie Q,Chen X,Li W

更新日期：2016-09-09 00:00:00

abstract：:Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing in vivo remain unknown. Using a combination of RNA sequencing and...

journal_title：Scientific reports

authors： Reijntjes DOJ,Lee JH,Park S,Schubert NMA,van Tuinen M,Vijayakumar S,Jones TA,Jones SM,Gratton MA,Xia XM,Yamoah EN,Pyott SJ

更新日期：2019-02-22 00:00:00