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Mendelian randomisation study of the relationship between vitamin D and risk of glioma.

Abstract：

:To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for 25(OH)D levels with glioma using SNP-glioma estimates from 12,488 cases and 18,169 controls, using inverse-variance weighted (IVW) and maximum likelihood estimation (MLE) methods. A non-significant association between 25(OH)D levels and glioma risk was shown using both the IVW (OR = 1.21, 95% confidence interval [CI] = 0.90-1.62, P = 0.201) and MLE (OR = 1.20, 95% CI = 0.98-1.48, P = 0.083) methods. In an exploratory analysis of tumour subtype, an inverse relationship between 25(OH)D levels and glioblastoma (GBM) risk was identified using the MLE method (OR = 0.62, 95% CI = 0.43-0.89, P = 0.010), but not the IVW method (OR = 0.62, 95% CI = 0.37-1.04, P = 0.070). No statistically significant association was shown between 25(OH)D levels and non-GBM glioma. Our results do not provide evidence for a causal relationship between 25(OH)D levels and all forms of glioma risk. More evidence is required to explore the relationship between 25(OH)D levels and risk of GBM.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Takahashi H,Cornish AJ,Sud A,Law PJ,Kinnersley B,Ostrom QT,Labreche K,Eckel-Passow JE,Armstrong GN,Claus EB,Il'yasova D,Schildkraut J,Barnholtz-Sloan JS,Olson SH,Bernstein JL,Lai RK,Schoemaker MJ,Simon M,Hoffmann P,

doi

10.1038/s41598-018-20844-w

subject

Has Abstract

pub_date

2018-02-05 00:00:00

pages

2339

issue

1

issn

2045-2322

pii

10.1038/s41598-018-20844-w

journal_volume

8

pub_type

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