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Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure.

Abstract：

:This study investigated the effect of various prebiotics (indigestible dextrin, α-cyclodextrin, and dextran) on human colonic microbiota at a dosage corresponding to a daily intake of 6 g of prebiotics per person (0.2% of dietary intake). We used an in vitro human colonic microbiota model based on batch fermentation starting from a faecal inoculum. Bacterial 16S rRNA gene sequence analysis showed that addition of 0.2% prebiotics did not change the diversity and composition of colonic microbiota. This finding coincided with results from a clinical study showing that the microbiota composition of human faecal samples remained unchanged following administration of 6 g of prebiotics over seven days. However, compared to absence of prebiotics, their addition reduced the pH and increased the generation of acetate and propionate in the in vitro system. Thus, even at such relatively low amounts, prebiotics appear capable of activating the metabolism of colonic microbiota.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Sasaki D,Sasaki K,Ikuta N,Yasuda T,Fukuda I,Kondo A,Osawa R

doi

10.1038/s41598-017-18877-8

subject

Has Abstract

pub_date

2018-01-11 00:00:00

pages

435

issue

1

issn

2045-2322

pii

10.1038/s41598-017-18877-8

journal_volume

8

pub_type

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