Abstract：
:Mutations in genes that encode components of tuberous sclerosis complex 2 (TSC2) are associated with tuberous sclerosis complex disease. TSC2 interacts with tuberous sclerosis complex 1 to form a complex that negatively regulates cell growth and proliferation via the inactivation of mechanistic target of rapamycin complex 1. The activity of TSC2 is mainly regulated via posttranslational modifications such as phosphorylation. However, the control of TSC2 activity is not entirely achieved by phosphorylation. In this study, we show that TSC2 is methylated at R1457 and R1459 by protein arginine methyltransferase 1 (PRMT1). Methylation of these two residues can affect the phosphorylation status through protein kinase B (Akt) of TSC2 at T1462 and is essential for TSC2 stability. Taken together, these findings indicate that novel posttranslational modifications are important for the regulation of TSC2 stability through PRMT1-mediated methylation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gen S,Matsumoto Y,Kobayashi KI,Suzuki T,Inoue J,Yamamoto Ydoi
10.1038/s41598-020-78274-6subject
Has Abstractpub_date
2020-12-03 00:00:00pages
21160issue
1issn
2045-2322pii
10.1038/s41598-020-78274-6journal_volume
10pub_type
杂志文章abstract：:The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60978-4
更新日期：2020-03-06 00:00:00
abstract：:The claim that organic agriculture produces higher levels of phytochemicals has been controversial for decades. Using strawberries as a model crop in field conditions, a preharvest leaf wounding stress was applied to study the production of phytochemicals in fruits. As a result phenolic compounds (PCs) and total solub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55033-w
更新日期：2019-12-17 00:00:00
abstract：:Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18994-4
更新日期：2018-01-15 00:00:00
abstract：:Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who und...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26212-y
更新日期：2018-05-18 00:00:00
abstract：:Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD+) and is a candidate molecule for regulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73984-3
更新日期：2020-10-20 00:00:00
abstract：:Aging is a highly controlled biological process characterized by a progressive deterioration of various cellular activities. One of several hallmarks of aging describes a link to transcriptional alteration, suggesting that it may impact the steady-state mRNA levels. We analyzed the mRNA steady-state levels of polyCAG-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10692
更新日期：2015-06-02 00:00:00
abstract：:Protein tyrosine kinase (PTK) activity has been implicated in pro-inflammatory gene expression following tumor necrosis factor-α (TNF-α) or interkeukin-1β (IL-1β) stimulation. However, the identity of responsible PTK(s) in cytokine signaling have not been elucidated. To evaluate which PTK is critical to promote the cy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44098-2
更新日期：2019-05-20 00:00:00
abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42271
更新日期：2017-02-13 00:00:00
abstract：:High efficiency polymer:fullerene photovoltaic device layers self-assemble with hierarchical features from ångströms to 100's of nanometers. The feature size, shape, composition, orientation, and order all contribute to device efficiency and are simultaneously difficult to study due to poor contrast between carbon bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30915
更新日期：2016-08-08 00:00:00
abstract：:In the present work, TiO2 nanoparticle and multi-walled carbon nanotubes composite powder is prepared hydrothermally. After doctor blading the paste from composite powder, the resulted composite film is sensitized with Cu-based metal-organic frameworks using a layer-by-layer deposition technique and the film is charac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03930
更新日期：2014-02-03 00:00:00
abstract：:Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27680
更新日期：2016-06-10 00:00:00
abstract：:Encephalitis is a hallmark of Nipah virus (NiV) infection in humans. The exact route of entry of NiV into the central nervous system (CNS) is unknown. Here, we performed a spatio-temporal analysis of NiV entry into the CNS of hamsters. NiV initially predominantly targeted the olfactory epithelium in the nasal turbinat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00736
更新日期：2012-01-01 00:00:00
abstract：:In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35021-2
更新日期：2018-11-09 00:00:00
abstract：:Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical loading resulting from embryo movement. We tested the hypothesis that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41926
更新日期：2017-02-06 00:00:00
abstract：:The development of selective visual attention is critical for effectively engaging with an ever-changing world. Its optimal deployment depends upon interactions between neural, motor, and sensory systems across multiple timescales and neurocognitive loci. Previous work illustrates the spatio-temporal dynamics of these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73187-w
更新日期：2020-10-14 00:00:00
abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32350
更新日期：2016-08-30 00:00:00
abstract：:Aconiti Lateralis Radix Praeparata (Fuzi) is obtained from processed daughter roots of Aconitum carmichaeli, a toxic plant with a high medical value well known in Chinese medicine. In addition to the known toxic alkaloids (aconitine, mesaconitine, and hypaconitine) and bioactive alkaloids (benzoylaconine, benzoylmesac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13499-6
更新日期：2017-10-12 00:00:00
abstract：:The recently evolved field of synthetic biology has revolutionized the way we think of biology as an "engineerable" discipline. The newly sprouted branch is constantly in need of simple, cost-effective and automatable DNA-assembly methods. We have developed a reliable DNA-assembly system, ZeBRα (Zero-Background Redα),...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39768-0
更新日期：2019-02-27 00:00:00
abstract：:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79666-4
更新日期：2021-01-14 00:00:00
abstract：:The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conducted using PubMed, the Cochran...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-01892-0
更新日期：2017-05-10 00:00:00
abstract：:Assassin bugs (Reduvioidea) are one of the most diverse (>7,000 spp.) lineages of predatory animals and have evolved an astounding diversity of raptorial leg modifications for handling prey. The evolution of these modifications is not well understood due to the lack of a robust phylogeny, especially at deeper nodes. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22177
更新日期：2016-02-26 00:00:00
abstract：:Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 hea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01487-9
更新日期：2017-05-02 00:00:00
abstract：:Microalgae and plankton can be a rich source of bioactivity. However, induction of secondary metabolite production in lab conditions can be difficult. One simple way of bypassing this issue is to collect biomass in the field and screen for bioactivity. Therefore, bulk net samples from three areas along the coast of no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15980-8
更新日期：2017-11-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23087-x
更新日期：2018-03-19 00:00:00
abstract：:Twirling is a technique widely used for converting arbitrary noise channels into Pauli channels in error threshold estimations of quantum error correction codes. It is vitally useful both in real experiments and in classical quantum simulations. Minimising the size of the twirling gate set increases the efficiency of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46722-7
更新日期：2019-08-02 00:00:00
abstract：:This study investigates the effects of aircraft cabin pressure on intracranial pressure (ICP) elevation of a pneumocephalus patient. We propose an experimental setup that simulates the intracranial hydrodynamics of a pneumocephalus patient during flight. It consists of an acrylic box (skull), air-filled balloon [intra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70614-w
更新日期：2020-08-12 00:00:00
abstract：:We compared the effects of 12-week programs of resistance training (RT), high-intensity interval aerobic training (HIAT), and moderate-intensity continuous aerobic training (MICT). The primary goal was to evaluate the therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43029
更新日期：2017-02-22 00:00:00
abstract：:Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet current therapeutic treatments are inadequate due to a complex disease pathogenesis. The plant polyphenol apigenin has been shown to have anti-inflammatory and neuroprotective properties in a number of cell and animal models; however...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31450
更新日期：2016-08-12 00:00:00
abstract：:Technical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50501-9
更新日期：2019-10-01 00:00:00
abstract：:The impact of reperfusion therapies on cognition has been poorly explored and little knowledge exists. We explored the influence of endovascular treatment (EVT) on cognitive outcome in patients with anterior circulation ischemic stroke. Patients presenting with ischemic stroke due to anterior large vessel occlusion wh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75609-1
更新日期：2020-10-28 00:00:00
