Abstract:
:Aging is a highly controlled biological process characterized by a progressive deterioration of various cellular activities. One of several hallmarks of aging describes a link to transcriptional alteration, suggesting that it may impact the steady-state mRNA levels. We analyzed the mRNA steady-state levels of polyCAG-encoding transgenes and endogenous genes under the control of well-characterized promoters for intestinal (vha-6), muscular (unc-54, unc-15) and pan-neuronal (rgef-1, unc-119) expression in the nematode Caenorhabditis elegans. We find that there is not a uniform change in transcriptional profile in aging, but rather a tissue-specific difference in the mRNA levels of these genes. While levels of mRNA in the intestine (vha-6) and muscular (unc-54, unc-15) cells decline with age, pan-neuronal tissue shows more stable mRNA expression (rgef-1, unc-119) which even slightly increases with the age of the animals. Our data on the variations in the mRNA abundance from exemplary cases of endogenous and transgenic gene expression contribute to the emerging evidence for tissue-specific variations in the aging process.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Adamla F,Ignatova Zdoi
10.1038/srep10692subject
Has Abstractpub_date
2015-06-02 00:00:00pages
10692issn
2045-2322pii
srep10692journal_volume
5pub_type
杂志文章abstract::The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10984
更新日期:2015-06-04 00:00:00
abstract::Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19208
更新日期:2016-01-18 00:00:00
abstract::Neurodevelopmental changes occur with asymmetric hearing loss, limiting binaural/spatial hearing and putting children at risk for social and educational challenges. These deficits may be mitigated by providing bilateral hearing in children through auditory prostheses. Effects on speech perception and spatial hearing w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31546-8
更新日期:2018-09-04 00:00:00
abstract::Inter-specific emotion recognition is especially adaptive when species spend a long time in close association, like dogs and humans. Here, we comprehensively studied the human ability to recognize facial expressions associated with dog emotions (hereafter, emotions). Participants were presented with pictures of dogs, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52938-4
更新日期:2019-11-11 00:00:00
abstract::We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55616-7
更新日期:2019-12-23 00:00:00
abstract::This study was aimed to explore the bidirectional association between depression and peptic ulcers. The ≥20-year-old participants of the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013 were included in the study. In study I, 30,306 depression patients were 1:4 matched with 121,224 con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58783-0
更新日期:2020-02-04 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarker...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55076-z
更新日期:2019-12-11 00:00:00
abstract::Plant-based proteins are increasingly being used in aquafeeds, but one of the limitations is taurine deficiency that can be especially detrimental for carnivorous fish. In this study, taurine supplementation in high plant protein diets (low fish meal, 15%) was investigated on the growth performance and fillet organole...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69014-x
更新日期:2020-07-23 00:00:00
abstract::Most complex systems are intrinsically dynamic in nature. The evolution of a dynamic complex system is typically represented as a sequence of snapshots, where each snapshot describes the configuration of the system at a particular instant of time. This is often done by using constant intervals but a better approach wo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39713
更新日期:2016-12-22 00:00:00
abstract::Epidemiological studies have shown that atherosclerotic risk factors accelerate the pathological process underlying Alzheimer's disease (AD) via chronic cerebral hypoperfusion. In this study, we aimed to clarify the mechanisms by which cerebral hypoperfusion may exacerbate AD pathology. We applied bilateral common car...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39494-7
更新日期:2019-02-26 00:00:00
abstract::Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35047
更新日期:2016-10-19 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-64342-4
更新日期:2020-05-08 00:00:00
abstract::A novel type of sub-lattice of the Jahn-Teller (JT) centers was arranged in Ti-doped barium hexaferrite BaFe12O19. In the un-doped crystal all iron ions, sitting in five different crystallographic positions, are Fe3+ in the high-spin configuration (S = 5/2) and have a non-degenerate ground state. We show that the elec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63915-7
更新日期:2020-04-27 00:00:00
abstract::Plant seed germination is a crucial developmental event that has significant effects on seedling establishment and yield production. This process is controlled by multiple intrinsic signals, particularly phytohormones. The gaseous hormone ethylene stimulates seed germination; however, the genetic basis of ethylene pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58607-1
更新日期:2020-02-03 00:00:00
abstract::The role of the actin cytoskeleton in relation to mitochondria function and dynamics is only recently beginning to be recognized. Myo19 is an actin-based motor that is bound to the outer mitochondrial membrane and promotes the localization of mitochondria to filopodia in response to glucose starvation. However, how gl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11002-9
更新日期:2017-09-14 00:00:00
abstract::The recent outbreaks of the insect-vectored Zika virus have demonstrated its potential to be sexually transmitted, which complicates modeling and our understanding of disease dynamics. Autochthonous outbreaks in the US mainland may be a consequence of both modes of transmission, which affect the outbreak size, duratio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43651-3
更新日期:2019-05-10 00:00:00
abstract::Biopharming for the production of recombinant pharmaceutical proteins in the mammary gland of transgenic animals is an attractive but laborious alternative compared to mammalian cell fermentation. The disadvantage of the lengthy process of genetically modifying an entire animal could be circumvented with somatic trans...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15115
更新日期:2015-10-14 00:00:00
abstract::Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17917-7
更新日期:2017-12-20 00:00:00
abstract::Prenatal skeletal muscle development genetically determines postnatal muscle characteristics such as growth and meat quality in pigs. However, the molecular mechanisms underlying prenatal skeletal muscle development remain unclear. Here, we performed the first genome-wide analysis of chimeric RNAs, single nuclear poly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29039
更新日期:2016-06-29 00:00:00
abstract::Plasmodium falciparum merozoite invasion into erythrocytes is an essential step of the blood-stage cycle, survival of parasites, and malaria pathogenesis. P. falciparum merozoite Rh5 interacting protein (PfRipr) forms a complex with Rh5 and CyRPA in sequential molecular events leading to erythrocyte invasion. Recently...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63611-6
更新日期:2020-04-20 00:00:00
abstract::The individual response of patients to propofol results from the influence of genetic factors. However, the state of knowledge in this matter still remains insufficient. The aim of our study was to determine genetic predictors of variable pharmacokinetics and pharmacodynamics of propofol within selected 9 genes coding...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-15657-2
更新日期:2017-11-13 00:00:00
abstract::At the present study, a one-dimensional model for the flat sheet direct contact membrane distillation (DCMD) for desalination purposes is proposed. Flows and membrane properties have been estimated by appropriate temperature-dependent correlations. Results show that the numerical model is in a very good agreement with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73964-7
更新日期:2020-10-08 00:00:00
abstract::The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying the transcriptomic profile of SST neurons could elucidate the uni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25110-7
更新日期:2018-05-01 00:00:00
abstract::Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07779-4
更新日期:2017-08-02 00:00:00
abstract::Vertical vergence is generally associated with one of three mechanisms: vestibular activation during a head tilt, induced by vertical visual disparity, or as a by-product of ocular torsion. However, vertical vergence can also be induced by seemingly unrelated visual conditions, such as optokinetic rotations. This stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72646-8
更新日期:2020-09-23 00:00:00
abstract::A large retreat of sea-ice in the 'stormy' Atlantic Sector of the Arctic Ocean has become evident through a series of record minima for the winter maximum sea-ice extent since 2015. Results from the Norwegian young sea ICE (N-ICE2015) expedition, a five-month-long (Jan-Jun) drifting ice station in first and second yea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45574-5
更新日期:2019-06-25 00:00:00
abstract::Contrary to a theoretical prediction, natural communities comprise many interacting species, thereby developing complex ecosystems. Earlier theoretical studies assumed that each component species within an ecological network has a simple life history, despite the fact that the interaction partners of many species, suc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11686-z
更新日期:2017-09-08 00:00:00
abstract::Recent studies have linked appearance of Paneth cells in colorectal adenomas to adenoma burden and male gender. However, the clinical importance of Paneth cells' associations with synchronous advanced adenoma (AA) and colorectal carcinoma (CRC) is currently unclear. We performed a comprehensive case-control study usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26129
更新日期:2016-05-18 00:00:00
abstract::There are few materials that are broadly used for fabricating optical metasurfaces for visible light applications. Gallium phosphide (GaP) is a material that, due to its optical properties, has the potential to become a primary choice but due to the difficulties in fabrication, GaP thin films deposited on transparent ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77753-0
更新日期:2020-11-26 00:00:00
abstract::Strengthening by precipitation of second phase is the guiding principle for the development of a host of high strength structural alloys, in particular, aluminium alloys for transportation sector. Higher efficiency and lower emission demands use of alloys at higher operating temperatures (200 °C-250 °C) and stresses, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11540-2
更新日期:2017-09-11 00:00:00