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A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition.

Abstract：

:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and EpiLCs, revealing that overall glycosylation undergoes dramatic changes from early stages of development. Remarkably, we showed for the first time the presence of a developmentally regulated network orchestrating glycosylation changes and identified polycomb repressive complex 2 (PRC2) as a key component involved in this process. Collectively, our findings provide novel insights into the naïve-to-primed pluripotent state transition and advance the understanding of glycosylation complex regulation during early mouse embryonic development.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pecori F,Yokota I,Hanamatsu H,Miura T,Ogura C,Ota H,Furukawa JI,Oki S,Yamamoto K,Yoshie O,Nishihara S

doi

10.1038/s41598-020-79666-4

subject

Has Abstract

pub_date

2021-01-14 00:00:00

pages

1276

issue

1

issn

2045-2322

pii

10.1038/s41598-020-79666-4

journal_volume

11

pub_type

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