Abstract：
:Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation. Consequently, mutations in specific integrins, or their deregulated expression, are associated with a variety of diseases. In the last decades, many integrin-specific ligands have been developed and used for modulation of integrin function in medical as well as biophysical studies. The IC50-values reported for these ligands strongly vary and are measured using different cell-based and cell-free systems. A systematic comparison of these values is of high importance for selecting the optimal ligands for given applications. In this study, we evaluate a wide range of ligands for their binding affinity towards the RGD-binding integrins αvβ3, αvβ5, αvβ6, αvβ8, α5β1, αIIbβ3, using homogenous ELISA-like solid phase binding assay.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kapp TG,Rechenmacher F,Neubauer S,Maltsev OV,Cavalcanti-Adam EA,Zarka R,Reuning U,Notni J,Wester HJ,Mas-Moruno C,Spatz J,Geiger B,Kessler Hdoi
10.1038/srep39805subject
Has Abstractpub_date
2017-01-11 00:00:00pages
39805issn
2045-2322pii
srep39805journal_volume
7pub_type
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