Abstract：
:Autophagy is a protective and life-sustaining process in which cytoplasmic components are packaged into double-membrane vesicles and targeted to lysosomes for degradation. Accumulating evidence supports that autophagy is associated with several pathological conditions. However, research on the functional cross-links between autophagy and disease genes remains in its early stages. In this study, we constructed a disease-autophagy network (DAN) by integrating known disease genes, known autophagy genes and protein-protein interactions (PPI). Dissecting the topological properties of the DAN suggested that nodes that both autophagy and disease genes (inter-genes), are topologically important in the DAN structure. Next, a core network from the DAN was extracted to analyze the functional links between disease and autophagy genes. The genes in the core network were significantly enriched in multiple disease-related pathways, suggesting that autophagy genes may function in various disease processes. Of 17 disease classes, 11 significantly overlapped with autophagy genes, including cancer diseases, metabolic diseases and hematological diseases, a finding that is supported by the literatures. We also found that autophagy genes have a bridging role in the connections between pairs of disease classes. Altogether, our study provides a better understanding of the molecular mechanisms underlying human diseases and the autophagy process.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang JY,Yao WX,Wang Y,Fan YL,Wu JBdoi
10.1038/srep44391subject
Has Abstractpub_date
2017-03-15 00:00:00pages
44391issn
2045-2322pii
srep44391journal_volume
7pub_type
杂志文章abstract：:Fluorescent probes that can distinguish different DNA topologies through changes in optical readout are sought after for DNA-based diagnostics. In this work, the 4,4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) chromophore attached to cyanophenyl substituents (BODIPY-CN) has been tethered to the 5'-end of the 15-m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35352-0
更新日期：2018-11-15 00:00:00
abstract：:The protection of tropical forests is one of the most urgent issues in conservation biology because of the rapid deforestation that has occurred over the last 50 years. Even in protected forests, the anthropogenic effects from newly expanding villages such as harvesting of medicinal plants, pasturing cattle and forest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14689
更新日期：2015-10-05 00:00:00
abstract：:Rice lines with slower starch digestibility provide opportunities in mitigating the global rise in type II diabetes and related non-communicable diseases. However, screening for low glycemic index (GI) in rice breeding programs is not possible due to time and cost constraints. This study evaluated the feasibility of u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06026-0
更新日期：2017-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10950-6
更新日期：2017-09-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2019-04-12 00:00:00
abstract：:Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish i...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-10-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48614-2
更新日期：2019-08-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42555
更新日期：2017-02-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28754
更新日期：2016-06-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-04-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33935
更新日期：2016-09-23 00:00:00
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journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46956
更新日期：2018-03-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28989-4
更新日期：2018-07-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44447
更新日期：2017-03-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28872-2
更新日期：2018-07-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58877-9
更新日期：2020-02-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58091-7
更新日期：2020-01-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46944-9
更新日期：2019-07-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37151
更新日期：2016-11-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05980
更新日期：2014-08-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39783-1
更新日期：2019-02-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24622
更新日期：2016-04-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36459-0
更新日期：2019-01-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33665
更新日期：2016-09-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08492
更新日期：2015-02-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32168
更新日期：2016-08-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39229
更新日期：2016-12-16 00:00:00
abstract：:Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH deficiency on the dev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09023
更新日期：2015-03-17 00:00:00
abstract：:Power semiconductor devices require low on-resistivity and high breakdown voltages simultaneously. Vertical-type metal-oxide-semiconductor field-effect transistors (MOSFETs) meet these requirements, but have been incompleteness in diamond. Here we show vertical-type p-channel diamond MOSFETs with trench structures and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28837-5
更新日期：2018-07-13 00:00:00
abstract：:To explore the association between methylation of antisense non-coding RNA in the INK4 locus (ANRIL) and coronary artery disease (CAD) development. Methylation levels of ANRIL in 100 subjects with CAD and 100 controls were quantitatively analyzed using Sequenom MassARRAY. Kyoto Encyclopedia of Genes and Genomes (KEGG)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51921-3
更新日期：2019-10-25 00:00:00
