A novel affinity-based method for the isolation of highly purified extracellular vesicles.

abstract：:Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as a hallmark of cancer development and progression. However, locus-specific difference of hydroxymethylation between colorectal cancer and normal tissue is unknown. In this study, we performed a newly developed method, HMST-seq, to pr...

journal_title：Scientific reports

authors： Li M,Gao F,Xia Y,Tang Y,Zhao W,Jin C,Luo H,Wang J,Li Q,Wang Y

更新日期：2016-08-22 00:00:00

abstract：:Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen ((1)O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively...

journal_title：Scientific reports

authors： Sokolovski SG,Zolotovskaya SA,Goltsov A,Pourreyron C,South AP,Rafailov EU

更新日期：2013-12-12 00:00:00

abstract：:During anaerobic digestion (AD) process, process parameters e.g., VFA, pH, COD removal … and kinetic parameters e.g., hydrolysis rate, lag phase and methane production potential… are the important indicator for illustrating AD process performance, however, the AD process performance based on these parameters remains p...

journal_title：Scientific reports

authors： Mao C,Zhang T,Wang X,Feng Y,Ren G,Yang G

更新日期：2017-08-24 00:00:00

abstract：:Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...

journal_title：Scientific reports

authors： Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

更新日期：2018-12-17 00:00:00

abstract：:α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene f...

journal_title：Scientific reports

authors： Ohtsuka Y,Kanagawa M,Yu CC,Ito C,Chiyo T,Kobayashi K,Okada T,Takeda S,Toda T

更新日期：2015-02-09 00:00:00

abstract：:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating disease with no molecular diagnostics and no treatment options. To identify potential markers of this illness, we profiled 48 patients and 52 controls for standard laboratory tests, plasma metabolomics, blood immuno-phenotyping a...

journal_title：Scientific reports

authors： Kitami T,Fukuda S,Kato T,Yamaguti K,Nakatomi Y,Yamano E,Kataoka Y,Mizuno K,Tsuboi Y,Kogo Y,Suzuki H,Itoh M,Morioka MS,Kawaji H,Koseki H,Kikuchi J,Hayashizaki Y,Ohno H,Kuratsune H,Watanabe Y

更新日期：2020-11-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zheng CM,Wang JY,Chen TT,Wu YC,Wu YL,Lin HT,Chiu SP,Chang TJ,Zheng JQ,Chu NF,Lin YM,Su SL,Lu KC,Chen JS,Sung FC,Lee CT,Yang Y,Hwang SJ,Wang MC,Hsu YH,Chiou HY,Kao S,Wu MY,Lin YF

更新日期：2020-04-15 00:00:00

abstract：:The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed significantly. The finer branches of the biliary tree are structurally and functionally complex and heterogeneo...

journal_title：Scientific reports

authors： Lewis PL,Su J,Yan M,Meng F,Glaser SS,Alpini GD,Green RM,Sosa-Pineda B,Shah RN

更新日期：2018-08-15 00:00:00

abstract：:Despite of the great scientific and technology interest, highly ordered full-Heusler L21-Co2MnAl films have remained a big challenge in terms of the availability and the electrical transport. Here we report the controllable growth and the intriguing transport behavior of epitaxial L21-Co2MnAl films, which exhibit a lo...

journal_title：Scientific reports

authors： Zhu LJ,Zhao JH

更新日期：2017-02-20 00:00:00

abstract：:Histone methyltransferase EZH2 is upregulated during osteoarthritis (OA), which is the most widespread rheumatic disease worldwide, and a leading cause of disability. This study aimed to assess the impact of EZH2 inhibition on cartilage degradation, inflammation and functional disability. In vitro, gain and loss of EZ...

journal_title：Scientific reports

authors： Allas L,Brochard S,Rochoux Q,Ribet J,Dujarrier C,Veyssiere A,Aury-Landas J,Grard O,Leclercq S,Vivien D,Ea HK,Maubert E,Cohen-Solal M,Boumediene K,Agin V,Baugé C

更新日期：2020-11-11 00:00:00

abstract：:The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulenc...

journal_title：Scientific reports

authors： Ancona V,Lee JH,Zhao Y

更新日期：2016-11-15 00:00:00

abstract：:Lateral flow strip tests are a cost-effective method for detecting specific proteins in biological samples, which can be performed in the field without specialized expertise. While most recognizable in the pregnancy tests, there are many other applications for lateral flow strip technology. The pest control industry h...

journal_title：Scientific reports

authors： Ko A,Choe DH

更新日期：2020-08-07 00:00:00

abstract：:Current knowledge about the overall and site-specific risk of malignancy associated with ankylosing spondylitis (AS) is inconsistent. We conducted a systematic review and meta-analysis to address this knowledge gap. Five databases (PubMed, EMBASE, Web of Science, the Cochrane library and the virtual health library) we...

journal_title：Scientific reports

authors： Deng C,Li W,Fei Y,Li Y,Zhang F

更新日期：2016-08-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Hassan R,Tantawy M,Gouda NA,Elzayat MG,Gabra S,Nabih A,Diab AA,El-Hadidi M,Bakry U,Shoeb MR,Elanany M,Shalaby L,Sayed AA

更新日期：2020-04-29 00:00:00

abstract：:Modern megaherbivore community richness is limited by bottom-up controls, such as resource limitation and resultant dietary competition. However, the extent to which these same controls impacted the richness of fossil megaherbivore communities is poorly understood. The present study investigates the matter with refere...

journal_title：Scientific reports

authors： Mallon JC

更新日期：2019-10-28 00:00:00

abstract：:In the past few years, the meteoric development of hybrid organic-inorganic perovskite solar cells (PSC) astonished the community. The efficiency has already reached the level needed for commercialization; however, the instability hinders its deployment on the market. Here, we report a mechanism to chemically stabiliz...

journal_title：Scientific reports

authors： El-Mellouhi F,Bentria el T,Rashkeev SN,Kais S,Alharbi FH

更新日期：2016-07-26 00:00:00

abstract：:Today's high-power laser systems are capable of reaching photon intensities up to 1022 W cm-2, generating plasmas when interacting with material. The high intensity and ultrashort laser pulse duration (fs) make direct observation of plasma dynamics a challenging task. In the field of laser-plasma physics and especiall...

journal_title：Scientific reports

authors： Haffa D,Bin J,Speicher M,Allinger K,Hartmann J,Kreuzer C,Ridente E,Ostermayr TM,Schreiber J

更新日期：2019-05-22 00:00:00

abstract：:To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...

journal_title：Scientific reports

authors： C Pardo P,Tilbrook B,van Ooijen E,Passmore A,Neill C,Jansen P,Sutton AJ,Trull TW

更新日期：2019-05-20 00:00:00

abstract：:To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...

journal_title：Scientific reports

authors： Chou H,Jima DD,Funk DH,Jackson JK,Sweeney BW,Buchwalter DB

更新日期：2020-11-05 00:00:00

abstract：:An antiferromagnetic topological insulator has been predicted to be preserved by breaking both time-reversal symmetry and primitive lattice translational symmetry. However, the topological surface state has often been observed to disappear in an antiferromagnetic phase because the doped magnetic impurity acts as an ex...

journal_title：Scientific reports

authors： Jun JH,Kim J,Kim SW,Jung MH

更新日期：2020-06-15 00:00:00

abstract：:Neuro-Behçet's disease (NBD) is subcategorized into parenchymal-NBD (P-NBD) and non-parenchymal-NBD types. Recently, P-NBD has been further subdivided into acute P-NBD (A-P-NBD) and chronic progressive P-NBD (CP-P-NBD). Although an increasing number of studies have reported the various clinical features of A-P-NBD and...

journal_title：Scientific reports

authors： Ishido M,Horita N,Takeuchi M,Shibuya E,Yamane T,Kawagoe T,Ishido T,Minegishi K,Yoshimi R,Kirino Y,Hirohata S,Ishigatsubo Y,Takeno M,Kaneko T,Mizuki N

更新日期：2017-08-31 00:00:00

abstract：:Data-independent acquisition mass spectrometry promises higher performance in terms of quantification and reproducibility compared to data-dependent acquisition mass spectrometry methods. To enable high-accuracy quantification of Staphylococcus aureus proteins, we have developed a global ion library for data-independe...

journal_title：Scientific reports

authors： Michalik S,Depke M,Murr A,Gesell Salazar M,Kusebauch U,Sun Z,Meyer TC,Surmann K,Pförtner H,Hildebrandt P,Weiss S,Palma Medina LM,Gutjahr M,Hammer E,Becher D,Pribyl T,Hammerschmidt S,Deutsch EW,Bader SL,Hecker M,Mo

更新日期：2017-09-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Tsuchiya K,Suzuki Y,Yoshimura K,Yasui H,Karayama M,Hozumi H,Furuhashi K,Enomoto N,Fujisawa T,Nakamura Y,Inui N,Yokomura K,Suda T

更新日期：2020-02-19 00:00:00

abstract：:By means of first principles calculation and experiments, a detailed mechanism is proposed to include the stages of slip, adjustment, and expansion for the HCP → FCC phase transformation with the prismatic relation of [Formula: see text] and [Formula: see text] in titanium. It is revealed that the formation of four FC...

journal_title：Scientific reports

authors： Yang JX,Zhao HL,Gong HR,Song M,Ren QQ

更新日期：2018-01-31 00:00:00

abstract：:Power induced wave collapse is one of the most fascinating phenomena in optics as it provides extremely high intensities, thus stimulating a range of nonlinear processes. For low power levels, propagation of beams in bulk media is dominated by diffraction, while above a certain threshold self-focusing is steadily enha...

journal_title：Scientific reports

authors： Muniz ALM,Wimmer M,Bisianov A,Morandotti R,Peschel U

更新日期：2019-07-02 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (...

journal_title：Scientific reports

authors： Fandiño J,Toba L,González-Matías LC,Diz-Chaves Y,Mallo F

更新日期：2020-10-22 00:00:00

abstract：:Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...

journal_title：Scientific reports

authors： Gopalakrishnan K,Aushev VN,Manservisi F,Falcioni L,Panzacchi S,Belpoggi F,Parada H Jr,Garbowski G,Hibshoosh H,Santella RM,Gammon MD,Teitelbaum SL,Chen J

更新日期：2020-04-27 00:00:00

abstract：:Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmanial target is an attr...

journal_title：Scientific reports

authors： Mao W,Daligaux P,Lazar N,Ha-Duong T,Cavé C,van Tilbeurgh H,Loiseau PM,Pomel S

更新日期：2017-04-07 00:00:00

abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...

journal_title：Scientific reports

authors： Suzuki Y,Sakamoto Y,Tanaka N,Okada H,Morikawa Y,Ogasawara W

更新日期：2014-03-06 00:00:00

abstract：:Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a singl...

journal_title：Scientific reports

authors： Wang B,Li Z,Xu W,Feng X,Wan Q,Zan Y,Sheng S,Shen X

更新日期：2017-03-24 00:00:00