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Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells.

Abstract：

:A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound-driven piezoelectric nanoparticle-assisted stimulation significantly reduced the proliferation by inducing the cell cycle arrest. Similarly to a low-intensity alternating electric field, chronic piezoelectric stimulation resulted able to inhibit cancer cell proliferation by upregulating the expression of the gene encoding Kir3.2 inward rectifier potassium channels, by interfering on Ca2+ homeostasis, and by affecting the organization of mitotic spindles during mitosis. The proposed platform, even if specific for HER2-positive cells, shows huge potential and versatility for the treatment of different type of cancers.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Marino A,Battaglini M,De Pasquale D,Degl'Innocenti A,Ciofani G

doi

10.1038/s41598-018-24697-1

subject

Has Abstract

pub_date

2018-04-19 00:00:00

pages

6257

issue

1

issn

2045-2322

pii

10.1038/s41598-018-24697-1

journal_volume

8

pub_type

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