Microbial biotransformation of DON: molecular basis for reduced toxicity.

abstract：:Concerted evolution is often observed in multigene families such as the CEA gene family. As a result, sequence similarity of paralogous genes is significantly higher than expected from their evolutionary distance. Gene conversion, a "copy paste" DNA repair mechanism that transfers sequences from one gene to another an...

journal_title：Scientific reports

authors： Hänske J,Hammacher T,Grenkowitz F,Mansfeld M,Dau TH,Maksimov P,Friedrich C,Zimmermann W,Kammerer R

更新日期：2020-02-25 00:00:00

abstract：:Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that pr...

journal_title：Scientific reports

authors： Yu H,Lu Y,Qiao X,Wei L,Fu T,Cai S,Wang C,Liu X,Zhong S,Wang Y

更新日期：2015-07-21 00:00:00

abstract：:Hypoplastic left heart syndrome (HLHS) is a fatal congenital heart disease in which the left side of the heart is underdeveloped, impairing the systemic circulation. Underdeveloped left ventricle exerts biomechanical stress on the right ventricle that can progress into heart failure. Genome-wide transcriptome changes ...

journal_title：Scientific reports

authors： Verma SK,Deshmukh V,Nutter CA,Jaworski E,Jin W,Wadhwa L,Abata J,Ricci M,Lincoln J,Martin JF,Yeo GW,Kuyumcu-Martinez MN

更新日期：2016-08-03 00:00:00

abstract：:Sea scorpions (Eurypterida, Chelicerata) of the Lower Devonian (~400 Mya) lived as large, aquatic predators. The structure of modern chelicerate eyes is very different from that of mandibulate compound eyes [Mandibulata: Crustacea and Tracheata (Hexapoda, such as insects, and Myriapoda)]. Here we show that the visual ...

journal_title：Scientific reports

authors： Schoenemann B,Poschmann M,Clarkson ENK

更新日期：2019-11-28 00:00:00

abstract：:Activation of different slip systems in hexagonal close packed (h.c.p.) metals depends primarily on the c/a ratio, which is an intrinsic property that can be altered through alloying addition. In conventional h.c.p. alloys where there is no diffusion-less phase transformation and associated transformation volume chang...

journal_title：Scientific reports

authors： Sinha S,Nene SS,Frank M,Liu K,Agrawal P,Mishra RS

更新日期：2019-09-12 00:00:00

abstract：:Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberate...

journal_title：Scientific reports

authors： Smaldino PE,Flamson TJ,McElreath R

更新日期：2018-03-20 00:00:00

abstract：:Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling mo...

journal_title：Scientific reports

authors： Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara G

更新日期：2017-08-03 00:00:00

abstract：:Insects' exoskeleton, gut, hemocoel, and cells are colonized by various microorganisms that often play important roles in their host life. Moreover, insects are frequently infected by vertically transmitted symbionts that can manipulate their reproduction. The aims of this study were the characterization of bacterial ...

journal_title：Scientific reports

authors： Kaczmarczyk A,Kucharczyk H,Kucharczyk M,Kapusta P,Sell J,Zielińska S

更新日期：2018-09-26 00:00:00

abstract：:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...

journal_title：Scientific reports

authors： Chen C,Nong Z,Xie Q,He J,Cai W,Tang X,Chen X,Huang R,Gao Y

更新日期：2017-07-27 00:00:00

abstract：:In this work, we demonstrate an innovative approach, combing a novel active screen plasma (ASP) technique with green chemical synthesis, for a direct fabrication of uniform Pt nanowire arrays on large-area supports. The ASP treatment enables in-situ N-doping and surface modification to the support surface, significant...

journal_title：Scientific reports

authors： Du S,Lin K,Malladi SK,Lu Y,Sun S,Xu Q,Steinberger-Wilckens R,Dong H

更新日期：2014-09-22 00:00:00

abstract：:Evolutions of Asian and Australian monsoons have important significance for understanding the past global change but are still a controversial subject. Here, we explore systematically the effects of plate movement and plateau uplift on the formation and evolution of the Asian and Australian monsoons by numerical simul...

journal_title：Scientific reports

authors： Liu X,Dong B,Yin ZY,Smith RS,Guo Q

更新日期：2017-01-13 00:00:00

abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...

journal_title：Scientific reports

authors： Yamasue M,Komiya K,Usagawa Y,Umeki K,Nureki SI,Ando M,Hiramatsu K,Nagai H,Kadota JI

更新日期：2020-01-31 00:00:00

abstract：:Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized medicine. Here we investigate the theranostic properties of topological insulator bismuth selenide (Bi2Se3) in in vivo and in vitro system for the ...

journal_title：Scientific reports

authors： Li J,Jiang F,Yang B,Song XR,Liu Y,Yang HH,Cao DR,Shi WR,Chen GN

更新日期：2013-01-01 00:00:00

abstract：:The demand for patterning functional materials precisely on surfaces of stimuli-responsive devices has increased in many research fields. In situ polymerization technology is one of the most convenient ways to place the functional materials on a desired location with micron-scale accuracy. To fabricate stimuli-respons...

journal_title：Scientific reports

authors： Jung Y,Lee H,Park TJ,Kim S,Kwon S

更新日期：2015-10-22 00:00:00

abstract：:BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymor...

journal_title：Scientific reports

authors： Chen SL,Lee SY,Chang YH,Wang TY,Chen SH,Chu CH,Chen PS,Yang YK,Hong JS,Lu RB

更新日期：2015-02-02 00:00:00

abstract：:The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibrob...

journal_title：Scientific reports

authors： Agnarelli A,Natali M,Garcia-Gil M,Pesi R,Tozzi MG,Ippolito C,Bernardini N,Vignali R,Batistoni R,Bianucci AM,Marracci S

更新日期：2018-07-13 00:00:00

abstract：:The macroscopically ordered structure of rod-like nanoapatites within the collagen matrix is of great significance for the mechanical performance of bones and teeth. However, the synthesis of macroscopically ordered nanoapatite remains a challenge. Inspired by the effect of citrate molecules on apatite crystals in nat...

journal_title：Scientific reports

authors： Tan J,Jin X,Chen M

更新日期：2019-01-24 00:00:00

abstract：:This paper proposes a novel "micro-gun" structure for laser pulse propulsion. The "micro-bullets" (glass microspheres) are irradiated by a laser pulse with a 10 ns duration in a dynamic process. Experimental parameters such as the microsphere diameter and the laser pulse energy are varied to investigate their influenc...

journal_title：Scientific reports

authors： Yu H,Li H,Cui L,Liu S,Yang J

更新日期：2017-11-24 00:00:00

abstract：:Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post v...

journal_title：Scientific reports

authors： Mold M,Shardlow E,Exley C

更新日期：2016-08-12 00:00:00

abstract：:A novel suite of instrumentation for the characterisation of materials held inside an air-tight tube furnace operated up to 250 °C has been developed. Real-time detection of released gases (volatile organic compounds (VOCs), CO2, NO, NO2, SO2, CO and O2) was achieved combining commercial off-the-shelf (COTS) gas senso...

journal_title：Scientific reports

authors： Lourenço C,Bergin S,Hodgkinson J,Francis D,Staines SE,Saffell JR,Walton C,Tatam RP

更新日期：2020-05-26 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain that affects millions of people every year. Yet identification of the specific IVD causing this pain is based on qualitative visual interpretation rather than objective findings. One possible approach to diagnosing pain-associated IVD c...

journal_title：Scientific reports

authors： Bez M,Zhou Z,Sheyn D,Tawackoli W,Giaconi JC,Shapiro G,Ben David S,Gazit Z,Pelled G,Li D,Gazit D

更新日期：2018-11-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Xiao G,Zhao L,Huang Q,Yang J,Du H,Guo D,Xia M,Li G,Chen Z,Wang D

更新日期：2018-10-18 00:00:00

abstract：:Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the format...

journal_title：Scientific reports

authors： Yang JC,Zhang Y,He SJ,Li MM,Cai XL,Wang H,Xu LM,Cao J

更新日期：2017-04-03 00:00:00

abstract：:To date, there is only scarce evidence for a considerable association of subjective and objective stress measures, which might be attributable to method bias (e.g., confounding) and/or asynchrony of their temporal changes. To validate different subjective stress measures by a physiological measure of long-term stress ...

journal_title：Scientific reports

authors： Weckesser LJ,Dietz F,Schmidt K,Grass J,Kirschbaum C,Miller R

更新日期：2019-01-31 00:00:00

abstract：:The cool sensor transient receptor potential melastatin channel 8 (TRPM8) is highly expressed in trigeminal and dorsal root ganglia, playing a key role in cold hypersensitivity associated to different peripheral neuropathies. Moreover, these channels are aberrantly expressed in different cancers, and seem to participa...

journal_title：Scientific reports

authors： Bonache MÁ,Martín-Escura C,de la Torre Martínez R,Medina A,González-Rodríguez S,Francesch A,Cuevas C,Roa AM,Fernández-Ballester G,Ferrer-Montiel A,Fernández-Carvajal A,González-Muñiz R

更新日期：2020-08-25 00:00:00

abstract：:River ecosystem health assessments provide the foundation for river ecological protection and integrated management. To evaluate the aquatic ecosystem health of the Fan River basin, benthic macroinvertebrate indices (the Multimeric Macroinvertebrates Index Flanders (MMIF) and Family Biotic Index (FBI)), a habitat inde...

journal_title：Scientific reports

authors： Chen J,Wang Y,Li F,Liu Z

更新日期：2019-10-01 00:00:00

abstract：:Focusing on the chemical basis of dietary selection while investigating the nutritional ecology of animals helps understand their feeding biology. It is also important to consider food abundance/biomass while studying the mechanism of animal food selection. We studied leaf selection in two Bornean folivorous primates ...

journal_title：Scientific reports

authors： Matsuda I,Tuuga A,Bernard H,Sugau J,Hanya G

更新日期：2013-01-01 00:00:00

abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...

journal_title：Scientific reports

authors： Lin C,Wang Y,Liu M,Li Q,Xiao W,Song X

更新日期：2020-07-23 00:00:00

abstract：:Sweetness is one of the main drivers of consumer preference, and thus is given high priority in apple breeding programmes. Due to the complexity of sweetness evaluation, soluble solid content (SSC) is commonly used as an estimation of this trait. Nevertheless, it has been demonstrated that SSC and sweet taste are poor...

journal_title：Scientific reports

authors： Aprea E,Charles M,Endrizzi I,Laura Corollaro M,Betta E,Biasioli F,Gasperi F

更新日期：2017-03-21 00:00:00

abstract：:Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system t...

journal_title：Scientific reports

authors： Sokame BM,Tonnang HEZ,Subramanian S,Bruce AY,Dubois T,Ekesi S,Calatayud PA

更新日期：2021-01-14 00:00:00