Abstract：
:Understanding past human settlement of inhospitable regions is one of the most intriguing puzzles in archaeological research, with implications for more sustainable use of marginal regions today. During the Byzantine period in the 4th century CE, large settlements were established in the arid region of the Negev Desert, Israel, but it remains unclear why it did so, and why the settlements were abandoned three centuries later. Previous theories proposed that the Negev was a "green desert" in the early 1st millennium CE, and that the Byzantine Empire withdrew from this region due to a dramatic climatic downturn. In the absence of a local climate archive correlated to the Byzantine/Early Islamic transition, testing this theory has proven challenging. We use stable isotopic indicators of animal dietary and mobility patterns to assess the extent of the vegetative cover in the desert. By doing so, we aim to detect possible climatic fluctuations that may have led to the abandonment of the Byzantine settlements. The findings show that the Negev Desert was not greener during the time period under investigation than it is today and that the composition of the animals' diets, as well as their grazing mobility patterns, remained unchanged through the Byzantine/Early Islamic transition. Favoring a non-climatic explanation, we propose instead that the abandonment of the Negev Byzantine settlements was motivated by restructuring of the Empire's territorial priorities.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vaiglova P,Hartman G,Marom N,Ayalon A,Bar-Matthews M,Zilberman T,Yasur G,Buckley M,Bernstein R,Tepper Y,Weissbrod L,Erickson-Gini T,Bar-Oz Gdoi
10.1038/s41598-020-58360-5subject
Has Abstractpub_date
2020-01-30 00:00:00pages
1512issue
1issn
2045-2322pii
10.1038/s41598-020-58360-5journal_volume
10pub_type
杂志文章abstract：:The transition from unicellular to multicellular organisms poses the question as to when genes that regulate cell-cell interactions emerged during evolution. The receptor and ligand pairing of plexins and semaphorins regulates cellular interactions in a wide range of developmental and physiological contexts. We survey...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38512-y
更新日期：2019-02-13 00:00:00
abstract：:The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15738
更新日期：2015-10-29 00:00:00
abstract：:The near infrared (NIR) absorption and average particle size of gold nanostars (GNSs) can be precisely controlled by varying the molar ratios of cucurbit[7]urils (CB[7]) and GNSs in aqueous solution. GNSs modified with CB[7] achieved high cargo loading with thermally activated release upon the NIR laser irradiation. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22239
更新日期：2016-02-26 00:00:00
abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13464-3
更新日期：2017-10-13 00:00:00
abstract：:Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification and differentiation of these neurons have been extensively studied, the molecul...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08900-3
更新日期：2017-08-17 00:00:00
abstract：:Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from high-throughput shotgun sequencing, viral DNA in a clinical sample typically constitutes a proportion of host DNA that is too small to be detecte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13201
更新日期：2015-08-19 00:00:00
abstract：:Trimethylation on H3K27 mediated by Polycomb Repressive Complex 2 (PRC2) is required to control gene repression programs involved in development, regulation of tissue homeostasis or maintenance and lineage specification of stem cells. In Drosophila, the PRC2 catalytic subunit is the single protein E(z), while in mamma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40738-9
更新日期：2019-03-13 00:00:00
abstract：:Allocation of limited nutrients, such as nitrogen (N) and phosphorus (P), among plant organs reflects the influences of evolutionary and ecological processes on functional traits of plants, and thus is related to functional groups and environmental conditions. In this study, we tested this hypothesis by exploring the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20099
更新日期：2016-02-05 00:00:00
abstract：:p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes. Changes in p97 ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46949-4
更新日期：2019-07-17 00:00:00
abstract：:This study evaluated the prognostic value of a panel of 29 oncogenes derived from the analysis of The Cancer Genome Atlas (TCGA data) or from the recent literature on bladder tumors on a well-characterized series of muscle-invasive bladder cancer (MIBC) and non-MIBC (NMIBC) samples and tried to identify molecular prog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73642-8
更新日期：2020-10-06 00:00:00
abstract：:This study was conducted to identify risk factors associated with AIV infections in live bird retail stalls (LBRS) in Lahore District, Pakistan. A cross-sectional survey of LBRS was conducted from December 2009-February 2010 using two-stage cluster sampling based on probability proportional to size. A total of 280 oro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23895-1
更新日期：2018-04-04 00:00:00
abstract：:Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid in the understanding of the physiologic variability....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12163
更新日期：2015-07-16 00:00:00
abstract：:There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55571-3
更新日期：2019-12-17 00:00:00
abstract：:'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These data require quality control assessment to optimise quality for clinical management and for robust large-scale data analysis in healthcare research. Height and weight data represent one of the mos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66925-7
更新日期：2020-06-23 00:00:00
abstract：:A topical medication combining calcipotriol (Cal) and betamethasone dipropionate (BDP) has proven effective in a number of randomized controlled trials performed in patients with psoriasis, but its mechanism of action has not been fully elucidated. We investigated whether the combination of Cal and BDP (Cal/BDP) in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52892-1
更新日期：2019-11-08 00:00:00
abstract：:Wetting phenomena in multi-phase systems govern the shape of the contact line which separates the different phases. For liquids in contact with solid surfaces wetting is typically described in terms of contact angle. While in macroscopic systems the contact angle can be determined experimentally, on the molecular scal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26111
更新日期：2016-05-17 00:00:00
abstract：:Resistance to adjuvant systemic treatment, including taxanes (docetaxel and paclitaxel) is a major clinical problem for breast cancer patients. lncRNAs (long non-coding RNAs) are non-coding transcripts, which have recently emerged as important players in a variety of biological processes, including cancer development ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36231-4
更新日期：2018-12-19 00:00:00
abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60149-5
更新日期：2020-02-25 00:00:00
abstract：:Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear. Here we demonstrate that AFSC-derived exosomes recapitulate the anti-apoptotic effect o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23120
更新日期：2016-03-16 00:00:00
abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33026-5
更新日期：2018-10-08 00:00:00
abstract：:Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04676-8
更新日期：2017-07-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58293-z
更新日期：2020-01-24 00:00:00
abstract：:A multi-angle light scattering (MALS) system, combined with chromatographic separation, directly measures the absolute molar mass, size and concentration of the eluate species. The measurement of these crucial properties in solution is essential in basic macromolecular characterization and all research and production ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09051-1
更新日期：2017-08-30 00:00:00
abstract：:Non-classical crystallisation (NCC) pathways are widely accepted, however there is conflicting evidence regarding the intermediate stages of crystallisation, how they manifest and further develop into crystals. Evidence from direct observations is especially lacking for small organic molecules, as distinguishing these...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75937-2
更新日期：2020-11-05 00:00:00
abstract：:RNA editing is a molecular event that alters specific nucleotides in RNA post-transcriptionally. RNA editing has the potential to impact a variety of cellular processes and is implicated in diseases such as cancer. Yet, the precise mechanisms by which RNA editing controls cellular processes are poorly understood. Here...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23226
更新日期：2016-03-16 00:00:00
abstract：:Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13169
更新日期：2015-08-19 00:00:00
abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34986-4
更新日期：2018-11-08 00:00:00
abstract：ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14708-y
更新日期：2017-10-27 00:00:00
abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31763-1
更新日期：2018-09-14 00:00:00
abstract：:Differential scanning fluorimetry is a popular method to estimate the stability of a protein in distinct buffer conditions by determining its 'melting point'. The method requires a temperature controlled fluorescence spectrometer or a RT-PCR machine. Here, we introduce a low-budget version of a microcontroller based h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19702-6
更新日期：2018-01-23 00:00:00
