当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer.

Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer.

Abstract：

:Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish in this patient population which tends to be older and plagued by comorbidities such as diabetes mellitus and hypertension. Therefore, novel, non-toxic therapies are urgently needed. Megestrol acetate is a frequently used drug in endometrial cancer patients. However, its response rate is only 20-30%. To enhance the activity of megestrol acetate in endometrial cancer patients, we explored the potential of combining natural supplements with megestrol acetate and found that the addition of the natural phenolic compound, pterostilbene, to megestrol acetate resulted in a synergistic inhibition of cancer cell growth in vitro and an enhanced reduction of tumor growth in a xenograft mouse model. In addition, dual treatment led to attenuation of signaling pathways, as well as cell cycle and survival pathways. Our results demonstrated for the first time that the anti-tumor activity of megestrol acetate can be enhanced by combining with pterostilbene, providing an insight into the potential application of pterostilbene and megestrol acetate combination for the treatment of endometrial cancer.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wen W,Lowe G,Roberts CM,Finlay J,Han ES,Glackin CA,Dellinger TH

doi

10.1038/s41598-017-12922-2

subject

Has Abstract

pub_date

2017-10-06 00:00:00

pages

12754

issue

1

issn

2045-2322

pii

10.1038/s41598-017-12922-2

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Neurodevelopment and asymmetry of auditory-related responses to repetitive syllabic stimuli in preterm neonates based on frequency-domain analysis.

    abstract：:Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47064-0

    authors： Daneshvarfard F,Abrishami Moghaddam H,Dehaene-Lambertz G,Kongolo G,Wallois F,Mahmoudzadeh M

    更新日期：2019-07-23 00:00:00

  • Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody.

    abstract：:Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specif...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22844

    authors： Fu J,Yao R,Luo Y,Yang D,Cao Y,Qiu Y,Song W,Miao S,Gu Y,Wang L

    更新日期：2016-03-09 00:00:00

  • Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1.

    abstract：:Matrix metalloproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia. Regulated MMP activity contributes to physiological synaptic plasticity, while dysregulated activity can stimulate injury. Disentangling the role individual MMPs play in synaptic plasticity is difficult due to overl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35497

    authors： Allen M,Ghosh S,Ahern GP,Villapol S,Maguire-Zeiss KA,Conant K

    更新日期：2016-10-20 00:00:00

  • Sub-wavelength annular-slit-assisted superoscillatory lens for longitudinally-polarized super-resolution focusing.

    abstract：:A binary metallic superoscillatory lens assisted with annular subwavelength slits is proposed, which generates a longitudinally-polarized super-resolution focal point. The annular slits are designed to selectively transmit radially-polarized light. Simulations using the finite element method show a 0.24 λ focal spot w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56810-3

    authors： Kim H,Rogers ETF

    更新日期：2020-01-28 00:00:00

  • Human platelet antigen 1-6, 9 and 15 in the Iranian population: An anthropological genetic analysis.

    abstract：:Human platelet antigens (HPAs) are membranous glycoproteins considered as alloantigens due to their polymorphisms. HPA-incompatibility in multiple pregnancies or blood transfusion can induce the development of alloantibodies leading to thrombocytopenia. The frequency of HPAs varies among populations, so that deep know...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64469-4

    authors： Kazemi MH,Malakootikhah F,Momeni-Varposhti Z,Falak R,Delbandi AA,Tajik N

    更新日期：2020-05-04 00:00:00

  • Developing a routine lab test for absolute quantification of HER2 in FFPE breast cancer tissues using Quantitative Dot Blot (QDB) method.

    abstract：:Developing immunoassay for absolute quantitation of protein biomarkers in Formalin Fixed Paraffin Embedded (FFPE) samples promises improved objectivity, consistency and accuracy in daily clinical practice. The feasibility of Quantitative Dot Blot (QDB) method for this purpose was explored in this study. We were able t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69471-4

    authors： Yu G,Zhang W,Zhang Y,Lv J,Wu S,Sui X,Zhang J,Tang F

    更新日期：2020-07-27 00:00:00

  • Publisher Correction: Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-62065-0

    authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

    更新日期：2020-04-22 00:00:00

  • Inter-individual variation in genes governing human hippocampal progenitor differentiation in vitro is associated with hippocampal volume in adulthood.

    abstract：:Hippocampal volumes are smaller in psychiatric disorder patients and lower levels of hippocampal neurogenesis are the hypothesized cause. Understanding which molecular processes regulate hippocampal progenitor differentiation might aid in the identification of novel drug targets that can promote larger hippocampal vol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15042-z

    authors： Powell TR,Murphy T,Lee SH,Duarte RRR,Lee HA,Smeeth D,Price J,Breen G,Thuret S

    更新日期：2017-11-08 00:00:00

  • Calibrating the Extended Hückel Method to Quantitatively Screen the Electronic Properties of Materials.

    abstract：:The extended Hückel (eH) tight-binding method has historically been prized for its computational ease and intuitive chemical clarity. However, its lack of quantitative predictiveness has prevented the eH method from being used as a tool for rapidly screening materials for desired electronic properties. In this work, w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28864-2

    authors： Grabill LP,Berger RF

    更新日期：2018-07-12 00:00:00

  • The Role of Charge Balance and Excited State Levels on Device Performance of Exciplex-based Phosphorescent Organic Light Emitting Diodes.

    abstract：:The design of novel exciplex-forming co-host materials provides new opportunities to achieve high device performance of organic light emitting diodes (OLEDs), including high efficiency, low driving voltage and low efficiency roll-off. Here, we report a comprehensive study of exciplex-forming co-host system in OLEDs in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12059-2

    authors： Lee S,Koo H,Kwon O,Jae Park Y,Choi H,Lee K,Ahn B,Min Park Y

    更新日期：2017-09-20 00:00:00

  • Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.

    abstract：:Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep10534

    authors： Wang Y,Liu Y,Yang L,Gu F,Li X,Zha R,Wei Z,Pei Y,Zhang P,Zhou Y,Zhang X

    更新日期：2015-06-11 00:00:00

  • Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging.

    abstract：:Liquid extraction surface analysis mass spectrometry imaging (LESA-MSI) has been shown to be an effective tissue profiling and imaging technique, producing robust and reliable qualitative distribution images of an analyte or analytes in tissue sections. Here, we expand the use of LESA-MSI beyond qualitative analysis t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37648

    authors： Swales JG,Strittmatter N,Tucker JW,Clench MR,Webborn PJH,Goodwin RJA

    更新日期：2016-11-24 00:00:00

  • Perceptual vision training in non-sport-specific context: effect on performance skills and cognition in young females.

    abstract：:Although an increasing interest in vision training for sport performance, whether it may have a transfer to sport-specific skills and whether such transfer could be mediated by cognition remain open issues. To enlighten this point, we tested the effect of 6-weeks sport vision training programmes (requiring generic or ...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-019-55252-1

    authors： Formenti D,Duca M,Trecroci A,Ansaldi L,Bonfanti L,Alberti G,Iodice P

    更新日期：2019-12-10 00:00:00

  • Species sorting during biofilm assembly by artificial substrates deployed in a cold seep system.

    abstract：:Studies focusing on biofilm assembly in deep-sea environments are rarely conducted. To examine the effects of substrate type on microbial community assembly, biofilms were developed on different substrates for different durations at two locations in the Red Sea: in a brine pool and in nearby bottom water (NBW) adjacen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06647

    authors： Zhang WP,Wang Y,Tian RM,Bougouffa S,Yang B,Cao HL,Zhang G,Wong YH,Xu W,Batang Z,Al-Suwailem A,Zhang XX,Qian PY

    更新日期：2014-10-17 00:00:00

  • Development and performance of a targeted whole exome sequencing enrichment kit for the dog (Canis Familiaris Build 3.1).

    abstract：:Whole exome sequencing is a technique that aims to selectively sequence all exons of protein-coding genes. A canine whole exome sequencing enrichment kit was designed based on the latest canine reference genome (build 3.1.72). Its performance was tested by sequencing 2 exome captures, each consisting of 4 pre-capture ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05597

    authors： Broeckx BJ,Coopman F,Verhoeven GE,Bavegems V,De Keulenaer S,De Meester E,Van Niewerburgh F,Deforce D

    更新日期：2014-07-07 00:00:00

  • An embryo of protocells: The capsule of graphene with selective ion channels.

    abstract：:The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating that graphene might be an embryo of protocell membrane. Firstly, we found that the highly oxidized graphene and phospholipid-graphene oxide ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10258

    authors： Li Z,Wang C,Tian L,Bai J,Yao H,Zhao Y,Zhang X,Cao S,Qi W,Wang S,Shi K,Xu Y,Mingliang Z,Liu B,Qiu H,Liu J,Wu W,Wang X,Wenzhen A

    更新日期：2015-05-19 00:00:00

  • Author Correction: Temperature dependence of protein-water interactions in a gated yeast aquaporin.

    abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41598-017-17040-7

    authors： Aponte-Santamaría C,Fischer G,Båth P,Neutze R,de Groot BL

    更新日期：2017-12-05 00:00:00

  • The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa.

    abstract：:This study investigated interactive effects of CYP2B6 genotypes and liver metastasis on the prognosis of metastatic breast cancer patients who received combined chemotherapy of docetaxel and thiotepa. Totally 153 patients were retrospectively genotyped rs8192719 (c.1294 + 53C > T) and rs2279343 (c.785A > G). Kaplan-Me...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep16775

    authors： Song Q,Zhou X,Yu J,Dong N,Wang X,Yang H,Ren J,Lyerly HK

    更新日期：2015-11-25 00:00:00

  • Different bacterial and viral pathogens trigger distinct immune responses in a globally invasive ant.

    abstract：:Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp.) and the viral co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41843-5

    authors： Lester PJ,Buick KH,Baty JW,Felden A,Haywood J

    更新日期：2019-04-08 00:00:00

  • Paper-based upconversion fluorescence resonance energy transfer biosensor for sensitive detection of multiple cancer biomarkers.

    abstract：:A paper-based upconversion fluorescence resonance energy transfer assay device is proposed for sensitive detection of CEA. The device is fabricated on a normal filter paper with simple nano-printing method. Upconversion nanoparticles tagged with specific antibodies are printed to the test zones on the test paper, foll...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23406

    authors： Xu S,Dong B,Zhou D,Yin Z,Cui S,Xu W,Chen B,Song H

    更新日期：2016-03-22 00:00:00

  • Unravelling the origin of the giant Zn deficiency in wurtzite type ZnO nanoparticles.

    abstract：:Owing to its high technological importance for optoelectronics, zinc oxide received much attention. In particular, the role of defects on its physical properties has been extensively studied as well as their thermodynamical stability. In particular, a large concentration of Zn vacancies in ZnO bulk materials is so far...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12914

    authors： Renaud A,Cario L,Rocquelfelte X,Deniard P,Gautron E,Faulques E,Das T,Cheviré F,Tessier F,Jobic S

    更新日期：2015-09-03 00:00:00

  • Microbial oil-degradation under mild hydrostatic pressure (10 MPa): which pathways are impacted in piezosensitive hydrocarbonoclastic bacteria?

    abstract：:Oil spills represent an overwhelming carbon input to the marine environment that immediately impacts the sea surface ecosystem. Microbial communities degrading the oil fraction that eventually sinks to the seafloor must also deal with hydrostatic pressure, which linearly increases with depth. Piezosensitive hydrocarbo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23526

    authors： Scoma A,Barbato M,Hernandez-Sanabria E,Mapelli F,Daffonchio D,Borin S,Boon N

    更新日期：2016-03-29 00:00:00

  • A new species of early-diverging Sauropodiformes from the Lower Jurassic Fengjiahe Formation of Yunnan Province, China.

    abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41598-020-67754-4

    authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

    更新日期：2020-07-03 00:00:00

  • Proteasome dysfunction in alveolar type 2 epithelial cells is associated with acute respiratory distress syndrome.

    abstract：:Proteasomes are a critical component of quality control that regulate turnover of short-lived, unfolded, and misfolded proteins. Proteasome activity has been therapeutically targeted and considered as a treatment option for several chronic lung disorders including pulmonary fibrosis. Although pharmacologic inhibition ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49020-4

    authors： Sitaraman S,Na CL,Yang L,Filuta A,Bridges JP,Weaver TE

    更新日期：2019-08-29 00:00:00

  • Leaf selection by two Bornean colobine monkeys in relation to plant chemistry and abundance.

    abstract：:Focusing on the chemical basis of dietary selection while investigating the nutritional ecology of animals helps understand their feeding biology. It is also important to consider food abundance/biomass while studying the mechanism of animal food selection. We studied leaf selection in two Bornean folivorous primates ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01873

    authors： Matsuda I,Tuuga A,Bernard H,Sugau J,Hanya G

    更新日期：2013-01-01 00:00:00

  • Image Quality and Radiation Dose for Prospectively Triggered Coronary CT Angiography: 128-Slice Single-Source CT versus First-Generation 64-Slice Dual-Source CT.

    abstract：:This study sought to compare the image quality and radiation dose of coronary computed tomography angiography (CCTA) from prospectively triggered 128-slice CT (128-MSCT) versus dual-source 64-slice CT (DSCT). The study was approved by the Medical Ethics Committee at Tongji Medical College of Huazhong University of Sci...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34795

    authors： Gu J,Shi HS,Han P,Yu J,Ma GN,Wu S

    更新日期：2016-10-18 00:00:00

  • Radiation Dosimetry of Inhaled Radioactive Aerosols: CFPD and MCNP Transport Simulations of Radionuclides in the Lung.

    abstract：:Despite extensive efforts in studying radioactive aerosols, including the transmission of radionuclides in different chemical matrices throughout the body, the internal organ-specific radiation dose due to inhaled radioactive aerosols has largely relied on experimental deposition data and simplified human phantoms. Co...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54040-1

    authors： Talaat K,Xi J,Baldez P,Hecht A

    更新日期：2019-11-25 00:00:00

  • Organic-Silica Interactions in Saline: Elucidating the Structural Influence of Calcium in Low-Salinity Enhanced Oil Recovery.

    abstract：:Enhanced oil recovery using low-salinity solutions to sweep sandstone reservoirs is a widely-practiced strategy. The mechanisms governing this remain unresolved. Here, we elucidate the role of Ca2+ by combining chemical force microscopy (CFM) and molecular dynamics (MD) simulations. We probe the influence of electroly...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10327-9

    authors： Desmond JL,Juhl K,Hassenkam T,Stipp SLS,Walsh TR,Rodger PM

    更新日期：2017-09-08 00:00:00

  • Flood-conditioned place aversion as a novel non-pharmacological aversive learning procedure in mice.

    abstract：:The place conditioning paradigm is an efficient, widely-used method to study mechanisms that underlie appetitive or aversive learning and memory processes. However, pharmacological agents used to induce conditioned place preference (CPP) or aversion (CPA) can per se interfere with learning and memory processing, hence...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25568-5

    authors： Goltseker K,Barak S

    更新日期：2018-05-08 00:00:00

  • Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments.

    abstract：:Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27602-y

    authors： Huang X,Zhong L,Post JN,Karperien M

    更新日期：2018-07-06 00:00:00