Spatial Quantitation of Drugs in tissues using Liquid Extraction Surface Analysis Mass Spectrometry Imaging.

abstract：:Traditional methods employed to discover new antibiotics are both a time-consuming and financially-taxing venture. This has led researchers to mine existing libraries of clinical molecules in order to repurpose old drugs for new applications (as antimicrobials). Such an effort led to the discovery of auranofin, a drug...

journal_title：Scientific reports

authors： Thangamani S,Mohammad H,Abushahba MF,Sobreira TJ,Hedrick VE,Paul LN,Seleem MN

更新日期：2016-03-03 00:00:00

abstract：:Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...

journal_title：Scientific reports

authors： Strand R,Whalan S,Webster NS,Kutti T,Fang JKH,Luter HM,Bannister RJ

更新日期：2017-05-22 00:00:00

abstract：:In this study, a novel resorufin thionocarbonate-based Hg2+-selective signaling probe (RT) for microfluidic paper-based analytical device (μPAD) applications is reported. The designed probe, RT, was readily synthesized by the one-step reaction of resorufin with phenyl thionochloroformate. The RT probe displayed a prom...

journal_title：Scientific reports

authors： Choi MG,Park SY,Park KY,Chang SK

更新日期：2019-03-04 00:00:00

abstract：:Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...

journal_title：Scientific reports

authors： Li T,Wang SK,Zhi XT,Zhou J,Dong ZR,Zhang ZL,Sun HC,Ye QH,Fan J

更新日期：2016-06-20 00:00:00

abstract：:Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using p...

journal_title：Scientific reports

authors： Kumar A,Jovel J,Lopez-Orozco J,Limonta D,Airo AM,Hou S,Stryapunina I,Fibke C,Moore RB,Hobman TC

更新日期：2018-04-03 00:00:00

abstract：:PP2A is a master controller of multiple inflammatory signaling pathways. It is a target in asthma; however the molecular mechanisms by which PP2A controls inflammation warrant further investigation. In A549 lung epithelial cells in vitro we show that inhibition of basal PP2A activity by okadaic acid (OA) releases rest...

journal_title：Scientific reports

authors： Rahman MM,Rumzhum NN,Morris JC,Clark AR,Verrills NM,Ammit AJ

更新日期：2015-05-18 00:00:00

abstract：:Dorso-ventral (DV) countershading is a highly-conserved pigmentary adaptation in vertebrates. In mammals, spatially regulated expression of agouti-signaling protein (ASIP) generates the difference in shading by driving a switch between the production of chemically-distinct melanins in melanocytes in dorsal and ventral...

journal_title：Scientific reports

authors： Cal L,Suarez-Bregua P,Comesaña P,Owen J,Braasch I,Kelsh R,Cerdá-Reverter JM,Rotllant J

更新日期：2019-03-05 00:00:00

abstract：:Prenatal ethanol exposure (PEE) is an established risk factor for intrauterine growth retardation. The present study was designed to determine whether PEE can increase the susceptibility of high-fat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear mo...

journal_title：Scientific reports

authors： He Z,Li J,Luo H,Zhang L,Ma L,Chen L,Wang H

更新日期：2015-12-03 00:00:00

abstract：:Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...

journal_title：Scientific reports

authors： Hu L,Wang J,Zhou X,Xiong Z,Zhao J,Yu R,Huang F,Zhang H,Chen L

更新日期：2016-09-12 00:00:00

abstract：:Ecdysteroids (arthropod molting hormones) play an important role in the development and sexual maturation of arthropods, and they have been shown to have anabolic and "energizing" effect in higher vertebrates. The aim of this study was to assess ecdysteroid diversity, levels according to bird species and months, as we...

journal_title：Scientific reports

authors： Hornok S,Csorba A,Kováts D,Csörgő T,Hunyadi A

更新日期：2019-11-18 00:00:00

abstract：:A visible light active Bi0.9Ho0.1FeO3 nanoparticles/TiO2 composite thin films with different mol.% of Bi0.9Ho0.1FeO3 were successfully prepared via non-aqueous sol-gel method. The incorporation of 5, 10 and 20 mol.% Bi0.9Ho0.1FeO3 nanoparticles in the precursor solution of TiO2 brings modifications in the functional p...

journal_title：Scientific reports

authors： Islam MR,Zubair MA,Bashar MS,Rashid AKMB

更新日期：2019-03-26 00:00:00

abstract：:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence ...

journal_title：Scientific reports

authors： Bessaud M,Joffret ML,Blondel B,Delpeyroux F

更新日期：2016-12-13 00:00:00

abstract：:Alterations in macronutrient intake can have profound effects on energy intake and whole-body metabolism. For example, reducing protein intake increases energy expenditure, increases insulin sensitivity and decreases body weight in rodents. Fibroblast growth factor 21 (FGF21) signaling in the brain is necessary for th...

journal_title：Scientific reports

authors： Flippo KH,Jensen-Cody SO,Claflin KE,Potthoff MJ

更新日期：2020-11-11 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neu...

journal_title：Scientific reports

authors： Gannon AL,O'Hara L,Mason JI,Rebourcet D,Smith S,Traveres A,Alcaide-Corral CJ,Frederiksen H,Jørgensen A,Milne L,Mitchell RT,Smith LB

更新日期：2019-03-01 00:00:00

abstract：:Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding and recoil. With ageing, the IFM becomes stiffer and less fatigu...

journal_title：Scientific reports

authors： Godinho MSC,Thorpe CT,Greenwald SE,Screen HRC

更新日期：2017-08-30 00:00:00

abstract：:Human group-specific component protein (Gc protein) is a multifunctional serum protein which has three common allelic variants, Gc1F, Gc1S and Gc2 in humans. Gc1 contains an O-linked trisaccharide [sialic acid-galactose-N-acetylgalactosamine (GalNAc)] on the threonine420 (Thr420) residue and can be converted to a pote...

journal_title：Scientific reports

authors： Nabeshima Y,Abe C,Kawauchi T,Hiroi T,Uto Y,Nabeshima YI

更新日期：2020-11-05 00:00:00

abstract：:Pulmonary fibrosis is a serious lung disorder that can lead to respiratory failure. Here we show that transgenic mice expressing active renin from the liver (RenTgMK) developed progressive pulmonary fibrosis leading to impaired pulmonary function. Histological analyses revealed a marked increase in extracellular matri...

journal_title：Scientific reports

authors： Wang J,Chen L,Chen B,Meliton A,Liu SQ,Shi Y,Liu T,Deb DK,Solway J,Li YC

更新日期：2015-10-23 00:00:00

abstract：:A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...

journal_title：Scientific reports

authors： Kim H,Choi MS,Inn KS,Kim BJ

更新日期：2016-07-01 00:00:00

abstract：:All species face the important adaptive problem of efficiently locating high-quality nutritional resources. We explored whether human spatial cognition is enhanced for high-calorie foods, in a large multisensory experiment that covertly tested the location memory of people who navigated a maze-like food setting. We fo...

journal_title：Scientific reports

authors： de Vries R,Morquecho-Campos P,de Vet E,de Rijk M,Postma E,de Graaf K,Engel B,Boesveldt S

更新日期：2020-10-08 00:00:00

abstract：:We report abnormal magnetic field effects on electrogenerated chemiluminescence (MFEECL) based on triplet emission from the Ru(bpy)3Cl2-TPrA electrochemical system: the appearance of MFEECL after magnetic field ceases. In early studies the normal MFEECL have been observed from electrochemical systems during the applic...

journal_title：Scientific reports

authors： Pan H,Shen Y,Wang H,He L,Hu B

更新日期：2015-03-16 00:00:00

abstract：:Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M incre...

journal_title：Scientific reports

authors： Volotskova O,Hawley TS,Stepp MA,Keidar M

更新日期：2012-01-01 00:00:00

abstract：:Porous three-dimensional (3D) polyurethane-based biocomposites were produced utilizing diatomite and hydroxyapatite as fillers. Diatomite and Hydroxyapatite (HA) were utilized to reinforce the morphological, chemical, mechanical, and thermal properties of polyurethane foam (PUF). Diatomite and Hydroxyapatite were adde...

journal_title：Scientific reports

authors： Mustafov SD,Sen F,Seydibeyoglu MO

更新日期：2020-08-06 00:00:00

abstract：:The phosphatases of regenerating liver (PRLs) are involved in tumorigenesis and metastatic cancer yet their cellular function remains unclear. Recent reports have shown PRL phosphatases bind tightly to the CNNM family of membrane proteins to regulate magnesium efflux. Here, we characterize the interactions between the...

journal_title：Scientific reports

authors： Zhang H,Kozlov G,Li X,Wu H,Gulerez I,Gehring K

更新日期：2017-03-03 00:00:00

abstract：:As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to form biofilms on medical devices resulting in high mortality. Biofilms formed by C. albicans are a c...

journal_title：Scientific reports

authors： Kakade P,Sadhale P,Sanyal K,Nagaraja V

更新日期：2016-08-08 00:00:00

abstract：:This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 wee...

journal_title：Scientific reports

authors： Lopez J,Quan A,Budihardjo J,Xiang S,Wang H,Kiron Koshy,Cashman C,Lee WPA,Hoke A,Tuffaha S,Brandacher G

更新日期：2019-02-28 00:00:00

abstract：:Three kinds of Al-TiO2 samples and pure TiO2 samples were synthesized via a modified polyacrylamide gel route using different aluminum salts, including Al2(SO4)3∙18H2O, AlCl3, and Al(NO3)3∙9H2O under identical conditions. The influence of different aluminum salts on the phase purity, morphologies, thermal stability of...

journal_title：Scientific reports

authors： Luo JL,Wang SF,Liu W,Tian CX,Wu JW,Zu XT,Zhou WL,Yuan XD,Xiang X

更新日期：2017-08-14 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:This paper has been retracted. ...

journal_title：Scientific reports

authors： Magar S,Nayak D,Mahajan UB,Patil KR,Shinde SD,Goyal SN,Swaminarayan S,Patil CR,Ojha S,Kundu CN

更新日期：2019-06-11 00:00:00

abstract：:GPR88 is an orphan G-protein-coupled receptor with predominant expression in reward-related areas in the brain. While the lack of GPR88 has been demonstrated to induce behavioral deficits, the potential function of the receptor in the control of food intake and energy balance remains unexplored. In this work, the role...

journal_title：Scientific reports

authors： Lau J,Farzi A,Enriquez RF,Shi YC,Herzog H

更新日期：2017-08-30 00:00:00