Abstract:
:Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In this study, we performed frequency and coherence analysis of preterm infants' auditory responses to series of syllables and also investigated the functional brain asymmetry of preterm infants for the detection of the regularity of auditory stimuli. Cortical auditory evoked potentials (CAEPs) were recorded in 16 preterm infants with a mean recording age of 31.48 weeks gestational age (29.57-34.14 wGA) in response to a repetitive syllabic stimulus. Peak amplitudes of the frequency response at the target frequency and the first harmonic, as well as the phase coherence (PC) at the target frequency were extracted as age-dependent variables. A functional asymmetry coefficient was defined as a lateralization index for the amplitude of the target frequency at each electrode site. While the findings revealed a significant positive correlation between the mean amplitude at the target frequency vs. age (R2 = 0.263, p = 0.042), no significant correlation was observed for age-related changes of the mean amplitude at the first harmonic. A significant correlation was also observed between the mean PC and age (R2 = 0.318, p = 0.023). A right hemisphere lateralization over many channels was also generally observed. The results demonstrate that rightward lateralization for slow rate modulation, previously observed in adults, children and newborns, appears to be in place at a very young age, even in preterm infants.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Daneshvarfard F,Abrishami Moghaddam H,Dehaene-Lambertz G,Kongolo G,Wallois F,Mahmoudzadeh Mdoi
10.1038/s41598-019-47064-0subject
Has Abstractpub_date
2019-07-23 00:00:00pages
10654issue
1issn
2045-2322pii
10.1038/s41598-019-47064-0journal_volume
9pub_type
杂志文章abstract::Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47633-3
更新日期:2019-08-01 00:00:00
abstract::X-ray phase-contrast imaging (XPCI) can dramatically improve soft tissue contrast in X-ray medical imaging. Despite worldwide efforts to develop novel XPCI systems, a numerical framework to rigorously predict the performance of a clinical XPCI system at a human scale is not yet available. We have developed such a tool...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12011
更新日期:2015-07-14 00:00:00
abstract::The precise clinicopathologic significance of myeloid differentiation primary response gene (MYD88) L265P mutation in diffuse large B-cell lymphomas (DLBCLs) remains elusive. To investigate the frequency and clinicopathologic significance of the MYD88 L265P mutation in DLBCLs, we conducted a meta-analysis of 40 publis...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-01998-5
更新日期:2017-05-11 00:00:00
abstract::Bacterial communities in wastewater treatment plants (WWTPs) affect plant functionality through their role in the removal of pollutants from wastewater. Bacterial communities vary extensively based on plant operating conditions and influent characteristics. The capacity of WWTPs can also affect the bacterial community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50952-0
更新日期:2019-10-15 00:00:00
abstract::Human induced pluripotent stem cells (hiPSCs) are expected to be both a revolutionary cell source for regenerative medicine and a powerful tool to investigate the molecular mechanisms underlying human cell development in vitro. In the present study, we tried to elucidate the steroidogenic differentiation processes usi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15485-4
更新日期:2017-11-09 00:00:00
abstract::Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) as another receptor for Ang1 and Ang2. Thrombomodulin is an endothelia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18912-8
更新日期:2018-01-11 00:00:00
abstract::Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68617-8
更新日期:2020-08-14 00:00:00
abstract::Transition metal dichalcogenides (TMDCs) are promising materials for sensing applications, due to their exceptional high performance in nano-electronics. Inherentely, the chemical and thermal responses of TMDCs are highly stable, hence, they pave way for real time sensor applications. This article proposes inceptively...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62397-x
更新日期:2020-03-26 00:00:00
abstract::Homogeneously distributed zinc nanoparticles (NPs) on the glass substrate were investigated for the transmittance, mechanical durability, and antibacterial effect. The buffered Ti NPs between Zn NPs and glass substrate were studied for an enhancement of the transmittance and mechanical endurance. The Ti NPs buffered Z...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06271
更新日期:2014-09-03 00:00:00
abstract::Understanding how animals respond to injury and how wounds heal remains a challenge. These questions can be addressed using genetically tractable animals, including the nematode Caenorhabditis elegans. Given its small size, the current methods for inflicting wounds in a controlled manner are demanding. To facilitate a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60333-7
更新日期:2020-02-27 00:00:00
abstract::Increasingly, biofilms are being recognised for their causative role in persistent infections (like cystic fibrosis, otitis media, diabetic foot ulcers) and nosocomial diseases (biofilm-infected vascular catheters, implants and prosthetics). Given the clinical relevance of biofilms and their recalcitrance to conventio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21839
更新日期:2016-02-25 00:00:00
abstract::We investigated how skeletal muscle mass (SMM) affects spinal sagittal balance (radiographic parameters) in symptomatic spinal patients. The first purpose of this study was to evaluate the body composition and the spinal sagittal alignment in symptomatic spinal patients. The second purpose of this study was to compare...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33867-0
更新日期:2018-10-19 00:00:00
abstract::The interest in nanostructures of silicon and its dopants has significantly increased. We report the creation of an ultimately-shallow junction at the surface of n-type silicon with excellent electrical and optical characteristics made by depositing an atomically thin boron layer at a relatively low temperature where ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13100-0
更新日期:2017-10-16 00:00:00
abstract::In this study, novel ZnS@In2S3 core@shell hollow nanospheres were fabricated by a facile refluxing method for the first time, and the formation mechanism of hollow structure with interior architecture was discussed based on ion-exchange Ostwald ripening. As the photocatalytic material for degradation of gaseous o-Dich...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16732-4
更新日期:2017-11-27 00:00:00
abstract::The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30225-y
更新日期:2018-08-03 00:00:00
abstract::The use of lithium (Li) metal anodes has been reconsidered because of the necessity for a higher energy density in secondary batteries. However, Li metal anodes suffer from 'dead' Li formation and surface deactivation which consequently form a porous layer of redundant Li aggregates. In this work, a fibrous metal felt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30830
更新日期:2016-08-03 00:00:00
abstract::Light-inducible gene regulation has great potential for remote and noninvasive control of the fate and function of target cells. One method to achieve such control is delivery of heat shock protein (HSP) promoter-driven protein expression vectors and photothermal heaters into the cells, followed by activation by illum...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04912-1
更新日期:2017-07-05 00:00:00
abstract::In this study, we investigated virioplankton decay rates and their responses to changes in temperature and photosynthetically active radiation (PAR) in the western Pacific Ocean. The mean decay rates for total, high-fluorescence, and low-fluorescence viruses were 1.64 ± 0.21, 2.46 ± 0.43, and 1.57 ± 0.26% h-1, respect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19678-3
更新日期:2018-01-24 00:00:00
abstract::HIV-1 env sequencing enables predictions of viral coreceptor tropism and phylogenetic investigations of transmission events. The aim of the study was to estimate the contribution of non-R5 strains to the viral spread in Poland. Partial proviral env sequences were retrieved from baseline blood samples of patients with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41407-7
更新日期:2019-03-21 00:00:00
abstract::Heart failure with preserved ejection fraction (HFpEF) affects more women than men, suggesting gender to play a major role in disease evolution. However, studies investigating gender differences in HFpEF are limited. In the present study we aimed to describe gender differences in a well-characterized HFpEF cohort. Con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19507-7
更新日期:2018-01-18 00:00:00
abstract::To describe the rationale and surgical technique and compare the clinical effect of posterior percutaneous endoscopic cervical discectomy (PPECD) using the Delta system versus that of conventional PPECD (key-hole) surgery for the treatment of symptomatic cervical spondylotic radiculopathy (CSR). A retrospective analys...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67381-z
更新日期:2020-06-24 00:00:00
abstract::We propose a hybrid plasmonic device consisting of a planar dielectric waveguide covering a gold nanostripe array fabricated on a gold film and investigate its guiding properties at telecom wavelengths. The fundamental modes of a hybrid device and their dependence on the key geometric parameters are studied. A communi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45196
更新日期:2017-03-24 00:00:00
abstract::Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Clinical trials have ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30841-8
更新日期:2018-08-17 00:00:00
abstract::Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14801
更新日期:2015-10-07 00:00:00
abstract::Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49000-8
更新日期:2019-08-29 00:00:00
abstract::Adaptive evolution by serial subcultivation of co-cultured Bacillus thuringiensis and Ketogulonicigenium vulgare significantly enhanced the productivity of 2-keto-L-gulonic acid in two-step vitamin C production. The adaptation mechanism in K. vulgare-B. thuringiensis consortium was investigated in this study based on ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46759
更新日期:2017-04-25 00:00:00
abstract::The impact of environment on individuals is particularly critical. In evolutionary games, adopting the strategy of the neighbor who performs better is nontrivial for the survival and maintenance of cooperation, in that such an action may help the agents to obtain higher benefit and more obvious evolutionary advantages...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34116-0
更新日期:2018-10-23 00:00:00
abstract::This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21130
更新日期:2016-02-17 00:00:00
abstract::Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40900-3
更新日期:2019-03-14 00:00:00
abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31375-9
更新日期:2018-09-04 00:00:00