Abstract：
:Increasingly, biofilms are being recognised for their causative role in persistent infections (like cystic fibrosis, otitis media, diabetic foot ulcers) and nosocomial diseases (biofilm-infected vascular catheters, implants and prosthetics). Given the clinical relevance of biofilms and their recalcitrance to conventional antibiotics, it is imperative that alternative therapeutics are proactively sought. We have developed dPABBs, a web server that facilitates the prediction and design of anti-biofilm peptides. The six SVM and Weka models implemented on dPABBs were observed to identify anti-biofilm peptides on the basis of their whole amino acid composition, selected residue features and the positional preference of the residues (maximum accuracy, sensitivity, specificity and MCC of 95.24%, 92.50%, 97.73% and 0.91, respectively, on the training datasets). On the N-terminus, it was seen that either of the cationic polar residues, R and K, is present at all five positions in case of the anti-biofilm peptides, whereas in the QS peptides, the uncharged polar residue S is preponderant at the first (also anionic polar residues D, E), third and fifth positions. Positive predictions were also obtained for 29 FDA-approved peptide drugs and ten antimicrobial peptides in clinical development, indicating at their possible repurposing for anti-biofilm therapy. dPABBs is freely accessible on: http://ab-openlab.csir.res.in/abp/antibiofilm/.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sharma A,Gupta P,Kumar R,Bhardwaj Adoi
10.1038/srep21839subject
Has Abstractpub_date
2016-02-25 00:00:00pages
21839issn
2045-2322pii
srep21839journal_volume
6pub_type
杂志文章abstract：:After the accident at the Fukushima Daiichi Nuclear Power Plant run by Tokyo Electric Power Company in 2011, breast milk samples obtained from volunteers living in Fukushima and neighboring prefectures were examined and small amounts of I-131 (2.2-36.3 Bq/kg) were detected in some samples. In this work, the I-131 conc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12426
更新日期：2015-07-22 00:00:00
abstract：:Over 80% of perinatal mortality in Japan is due to stillbirths after 22 weeks of gestation, with one in 300 families experiencing fetal loss every year. This study aimed to assess causes and risk factors for singleton stillbirth in Japan. A retrospective cross-sectional study was conducted using the Japan Society of O...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-22546-9
更新日期：2018-03-07 00:00:00
abstract：:The N-methyl-D-aspartate subfamily of ionotropic glutamate receptors (NMDARs) is well known for its important roles in the central nervous system (CNS), e.g. learning and memory formation. Besides the CNS, NMDARs are also expressed in numerous peripheral tissues including the pancreas, kidney, stomach, and blood cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46496-y
更新日期：2019-07-11 00:00:00
abstract：:Photoactivated localization microscopy (PALM) is a super-resolution imaging technique based on the detection and subsequent localization of single fluorescent molecules. PALM is therefore a powerful tool in resolving structures and putative interactions of biomolecules at the ultimate analytical detection limit. Howev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13532
更新日期：2015-09-01 00:00:00
abstract：:A growing bacterium typically divides into two genetically identical and morphologically similar sister cells and eventually gives rise to a clonal population. Nevertheless, significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting heterogeneity in cellular behavior often ensuri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08660-0
更新日期：2017-08-16 00:00:00
abstract：:Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76935-0
更新日期：2020-11-16 00:00:00
abstract：:Canadian Indigenous peoples (First Nations and Inuit) exhibit a high burden of infectious diseases including tuberculosis influenced by societal factors, and biological determinants. Toll-like receptor (TLR)-mediated innate immune responses are the first line of defence against infections. We examined the production o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50596-0
更新日期：2019-10-02 00:00:00
abstract：:Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77639-1
更新日期：2020-11-25 00:00:00
abstract：:The major source of ATP in cancer cells remains unclear. Here, we examined energy metabolism in gastric cancer cells and found increased fatty acid oxidation and increased expression of ALDH3A1. Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production of 4-hydroxynonen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52814-1
更新日期：2019-11-08 00:00:00
abstract：:Salinity is one of the major abiotic factors that affect productivity in oat. Here, we report a comparison of the transcriptomes of two hexaploid oat cultivars, 'Hanyou-5' and 'Huazao-2', which differ with respect to salt tolerance, in seedlings exposed to salt stress. Analysis of the assembled unigenes from the osmot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34505-5
更新日期：2018-11-02 00:00:00
abstract：:Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26355
更新日期：2016-05-23 00:00:00
abstract：:Metallic glass (MG) generally fails in a brittle manner under uniaxial tension loading at room temperature. The lack of plastic strain of MG is due to the severe plastic instability via the easily formed one dominate shear band. There have been several approaches to improve the ductility in MG, but achieving uniform t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03319
更新日期：2013-11-25 00:00:00
abstract：:Pot experiments were carried out to study the effects of rice straw (RS) and rice straw ash (RSA) on the growth of early rice and α-diversity of bacterial community in soils around rare earth mining areas of Xunwu and Xinfeng counties in South Jiangxi of China. The results showed that the exploitation of rare earth re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67160-w
更新日期：2020-06-25 00:00:00
abstract：:C-reactive protein (CRP) is an acute-phase plasma protein that can be used as a biomarker for activation of the immune system. A spectral analysis of CRP level over time for patients with gynaecological tumours has been reported by Madondo et al., using a periodogram method, suggesting that there is no significant per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30469-8
更新日期：2018-08-10 00:00:00
abstract：:Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81453-8
更新日期：2021-01-21 00:00:00
abstract：:The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work systematically demonstrates droplet dispensing into immiscible fluids through electric charge concentrati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31901
更新日期：2016-08-18 00:00:00
abstract：:Boreal forests play critical roles in global carbon, water and energy cycles. Recent studies suggest drought is causing a decline in boreal spruce growth, leading to predictions of widespread mortality and a shift in dominant vegetation type in interior Alaska. We took advantage of a large set of tree cores collected ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15644-7
更新日期：2017-11-10 00:00:00
abstract：:Gastric cancer is one of the most aggressive cancers and is the second leading cause of cancer death worldwide. Approximately 40% of global gastric cancer cases occur in China, with peritoneal metastasis being the prevalent form of recurrence and metastasis in advanced disease. Currently, there are limited clinical ap...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13750
更新日期：2015-09-02 00:00:00
abstract：:Cake layer formation in membrane processes is an inevitable phenomenon. For hard particles, especially cake porosity and thickness determine the membrane flux, but when the particles forming the cake are soft, the variables one has to take into account in the prediction of cake behavior increase considerably. In this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39820-z
更新日期：2019-02-28 00:00:00
abstract：:Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45333
更新日期：2017-03-28 00:00:00
abstract：:Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62044-5
更新日期：2020-03-20 00:00:00
abstract：:We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33932-8
更新日期：2018-10-19 00:00:00
abstract：:This study evaluated the impact of mechanically stimulated saliva on initial bacterial colonization. Interaction between oral bacteria and both unstimulated and stimulated saliva was examined in vitro by laying labeled bacteria over SDS-PAGE-separated salivary proteins. The effects of chewing on in vivo biofilm, micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48211-3
更新日期：2019-08-14 00:00:00
abstract：:We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78945-4
更新日期：2020-12-14 00:00:00
abstract：:De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate turnover and dietary sources also makes a significant contribution to the intracellular pool. Herein we ask whether dietary GlcNAc regulates nutrien...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23043
更新日期：2016-03-14 00:00:00
abstract：:A top-down scalable method to produce flexible water and blood repellent tubes is introduced. The method is based on replication of overhanging nanostructures from an aluminum tube template to polydimethylsiloxane (PDMS) via atomic layer deposition (ALD) assisted sacrificial etching. The nanostructured PDMS/titania tu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16369-3
更新日期：2017-11-22 00:00:00
abstract：:The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40903
更新日期：2017-01-18 00:00:00
abstract：:Landau-Zener (LZ) transition has received renewed interest as an alternative approach to control single-qubit states. An LZ transition occurs when a system passes through an avoided crossing that arises from quantum mechanical coupling of two levels, taking the system to a coherent superposition of the two states. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23468-2
更新日期：2018-04-03 00:00:00
abstract：:Evolution of resistance threatens sustainability of transgenic crops producing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt). The fall armyworm (Spodoptera frugiperda) is a devastating pest of corn in the Western Hemisphere initially controlled by transgenic Bt corn producing the Cry1Fa insectic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09866-y
更新日期：2017-09-07 00:00:00
abstract：:Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19787
更新日期：2016-01-25 00:00:00
