Abstract：
:Zika virus (ZIKV) is an emerging mosquito-borne pathogen representing a global health concern. It has been linked to fetal microcephaly and other birth defects and neurological disorders in adults. Sanofi Pasteur has engaged in the development of an inactivated ZIKV vaccine, as well as a live chimeric vaccine candidate ChimeriVax-Zika (CYZ) that could become a preferred vaccine depending on future ZIKV epidemiology. This report focuses on the CYZ candidate that was constructed by replacing the pre-membrane and envelope (prM-E) genes in the genome of live attenuated yellow fever 17D vaccine virus (YF 17D) with those from ZIKV yielding a viable CYZ chimeric virus. The replication rate of CYZ in the Vero cell substrate was increased by using a hybrid YF 17D-ZIKV signal sequence for the prM protein. CYZ was highly attenuated both in mice and in human in vitro models (human neuroblastoma and neuronal progenitor cells), without the need for additional attenuating modifications. It exhibited significantly reduced viral loads in organs compared to a wild-type ZIKV and a complete lack of neuroinvasion following inoculation of immunodeficient A129 mice. A single dose of CYZ elicited high titers of ZIKV-specific neutralizing antibodies in both immunocompetent and A129 mice and protected animals from ZIKV challenge. The data indicate that CYZ is a promising vaccine candidate against ZIKV.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Giel-Moloney M,Goncalvez AP,Catalan J,Lecouturier V,Girerd-Chambaz Y,Diaz F,Maldonado-Arocho F,Gomila RC,Bernard MC,Oomen R,Delagrave S,Burdin N,Kleanthous H,Jackson N,Heinrichs J,Pugachev KVdoi
10.1038/s41598-018-31375-9subject
Has Abstractpub_date
2018-09-04 00:00:00pages
13206issue
1issn
2045-2322pii
10.1038/s41598-018-31375-9journal_volume
8pub_type
杂志文章abstract：:Few studies have examined the potential transcription factor (TF) simultaneously associated with cisplatin resistance and metastasis in ovarian cancer. To assess a related mechanism, a 345-channel protein/DNA array and transcriptional activity ELISA were performed to compare the TF activities in the cisplatin-sensitiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31030-3
更新日期：2018-09-07 00:00:00
abstract：:Neuromuscular impairment requires adherence to a rehabilitation regimen for maximum recovery of motor function. Consumer-grade game controllers have emerged as a viable means to relay supervised physical therapy to patients' homes, thereby increasing their accessibility to healthcare. These controllers allow patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59927-y
更新日期：2020-02-28 00:00:00
abstract：:Post-transplant cyclophosphamide has become a promising medical option after allogeneic HSCT. In this study we aimed to evaluate the efficacy of cyclophosphamide and cyclosporine combination in acute and chronic graft-versus-host disease (GvHD) prophylaxis in acute myeloid leukemia (AML) cases scheduled for allogeneic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38644-1
更新日期：2019-02-14 00:00:00
abstract：:Adding fluoride into bioactive glasses leads to fluorapatite formation and a decrease in glass transition temperature. Recently, chloride has been introduced into glasses as an alternative to fluoride. The presence of the large chloride ion lowers glass crystallisation tendency and increases glass molar volume, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19544-2
更新日期：2018-01-22 00:00:00
abstract：:Peste des petits ruminants (PPR) is a highly contagious and devastating viral disease affecting mainly sheep and goats, but also a large number of wild species within the order Artiodactyla. A better understanding of PPR transmission dynamics in multi-host systems is necessary to efficiently control the disease, in pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41232-y
更新日期：2019-03-18 00:00:00
abstract：:We aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reverse...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54606-z
更新日期：2019-12-02 00:00:00
abstract：:The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39005-8
更新日期：2019-02-21 00:00:00
abstract：:The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety of cells where it regulates a number of cell behaviours including proliferation and differentiation. Panx1 is expressed on the cell surface as well as intracellular membranes. Previous work suggests that a region within the proximal Panx1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46144-5
更新日期：2019-07-05 00:00:00
abstract：:The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in northeast Asia. The Changbai Mountains and the Korean peninsula (CM/KP) are usually considered to be the LGM refugia for P. koraiensis. Howe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18608
更新日期：2015-12-22 00:00:00
abstract：:Shape memory alloys are typical temperature-sensitive metallic functional materials due to superelasticity and shape recovery characteristics. The conventional shape memory effect involves the formation and deformation of thermally induced martensite and its reverse transformation. The shape recovery process usually t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21754
更新日期：2016-02-16 00:00:00
abstract：:Nocardia is an opportunistic pathogen that most frequently affects the lungs. Evidence is limited regarding the risk factors for nocardiosis. The current study assessed clinical correlates of nocardiosis. A retrospective study was conducted based on medical records of consecutive adult patients (N = 60) with nocardios...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71214-4
更新日期：2020-08-31 00:00:00
abstract：:Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/s41598-018-31266-z
更新日期：2018-08-28 00:00:00
abstract：:The controlled interaction of two high intensity beams opens new degrees of freedom for manipulating electromagnetic waves in air. The growing number of applications for laser filaments requires fine control of their formation and propagation. We demonstrate, experimentally and theoretically, that the attraction and f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10565-x
更新日期：2017-08-31 00:00:00
abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30960-2
更新日期：2018-08-24 00:00:00
abstract：:Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64753-3
更新日期：2020-05-12 00:00:00
abstract：:Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27899
更新日期：2016-06-14 00:00:00
abstract：:Despite growing acknowledgement of the role of oxidized fatty acids (oxFA) as cellular signaling molecules and in the pathogenesis of disease, developing methods to measure these species in biological samples has proven challenging. Here we describe a novel method utilizing HPLC-ESI-MS/MS to identify and quantify mult...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47693-5
更新日期：2019-08-01 00:00:00
abstract：:Understanding the drivers of animal movement is significant for ecology and biology. Yet researchers have so far been unable to fully understand these drivers, largely due to low data resolution. In this study, we analyse a high-frequency movement dataset for a group of grazing cattle and investigate their spatiotempo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31967
更新日期：2016-08-24 00:00:00
abstract：:This paper examines how a move from traditional post-harvest operations of smallholder rice farms in the Ayeyarwaddy delta, Myanmar, to improved post-harvest operations affected income, energy efficiency and greenhouse gas emissions (GHGE). Harvest and post-harvest losses were investigated in a field experiment with 5...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76639-5
更新日期：2020-11-13 00:00:00
abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly. Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in senile plaques in brain of AD patients. To understand Zn-chelated Aβ (ZnAβ) species, here we systematically characterized ZnAβ aggregates by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23122-x
更新日期：2018-03-19 00:00:00
abstract：:The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30431-8
更新日期：2018-08-17 00:00:00
abstract：:We study theoretically and numerically the kinetics of the coefficient of friction of an elastomer due to abrupt changes of sliding velocity. Numerical simulations reveal the same qualitative behavior which has been observed experimentally on different classes of materials: the coefficient of friction first jumps and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05795
更新日期：2014-07-28 00:00:00
abstract：:Thermo-elasticity couples the deformation of an elastic (solid) body to its temperature and vice-versa. It is a solid-like property. Highlighting such property in liquids is a paradigm shift: it requires long-range collective interactions that are not considered in current liquid descriptions. The present microthermal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69404-1
更新日期：2020-08-07 00:00:00
abstract：:In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71365-4
更新日期：2020-09-03 00:00:00
abstract：:Rivers are an important aquatic conduit that connects terrestrial sources of dissolved inorganic carbon (DIC) and other elements with oceanic reservoirs. The Mekong River, one of the world's largest rivers, is firstly examined to explore inter-annual fluxes of dissolved and particulate constituents during 1923-2011 an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16005
更新日期：2015-11-02 00:00:00
abstract：:Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between European UP "cultures" and past population dynamics, they leave open numerous questions reg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78841-x
更新日期：2020-12-14 00:00:00
abstract：:Single-walled carbon nanotubes (SWCNTs) have been modified with ester groups using typical organic radical chemistry. Consequently, traps for mobile excitons have been created, which enhanced the optical properties of the material. The proposed methodology combines the benefits of mainstream approaches to create lumin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76716-9
更新日期：2020-11-16 00:00:00
abstract：:Delivery of proteins has been regarded as the safest and most useful application in therapeutic application of stem cells, because proteins can regulate gene expression transiently without any genomic alteration. However, it is difficult to accurately measure efficiency or quantity of intracellular protein uptake. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04378
更新日期：2014-03-14 00:00:00
abstract：:In the central nervous system of vertebrates, cell bodies of neurons are often assembled as nuclei or cellular layers that play specific roles as functional units. The purpose of this work was to selectively highlight such cell assemblies by magnetic resonance imaging using signals from water protons that are associat...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/s41598-019-41587-2
更新日期：2019-03-25 00:00:00
abstract：:Inner Mongolia cashmere goats, as an important part of animal husbandry production, play an important role in animal fiber industry. In recent years, scientific research has made a lot of explorations on the molecular regulation mechanism of hair follicle cycle growth, but few studies have been reported on the develop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60351-5
更新日期：2020-03-11 00:00:00
