Abstract：
:Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. We describe the development of novel assays to detect autoantibodies specific to two distinct components of the mitochondrion: the mitochondrial outer membrane and mitochondrial DNA. Antibodies to these two mitochondrial constituents were increased in both human and murine systemic lupus erythematosus (SLE), compared to controls, and were present at higher levels than in patients with antiphospholipid syndrome or primary biliary cirrhosis. In both bi- and multi-variate regression models, antibodies to mitochondrial DNA, but not whole mitochondria, were associated with increased anti-dsDNA antibodies and lupus nephritis. This study describes new and optimized methods for the assessment of anti-mitochondrial antibodies, and demonstrates their presence in both human and murine SLE. These findings suggest that different mitochondrial components are immunogenic in SLE, and support the concept that extracellular mitochondria may provide an important source of circulating autoantigens in SLE.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Becker Y,Loignon RC,Julien AS,Marcoux G,Allaeys I,Lévesque T,Rollet-Labelle E,Benk-Fortin H,Cloutier N,Melki I,Eder L,Wagner É,Pelletier M,Hajj HE,Tremblay MÈ,Belleannée C,Hébert MJ,Dieudé M,Rauch J,Fortin PR,Boildoi
10.1038/s41598-019-40900-3subject
Has Abstractpub_date
2019-03-14 00:00:00pages
4530issue
1issn
2045-2322pii
10.1038/s41598-019-40900-3journal_volume
9pub_type
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