当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization.

Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization.

Abstract：

:Alzheimer's disease (AD) is characterized by excessive production and deposition of amyloid-beta (Aβ) proteins as well as synapse dysfunction and loss. While soluble Aβ oligomers (AβOs) have deleterious effects on synapse function and reduce synapse number, the underlying molecular mechanisms are not well understood. Here we screened synaptic organizer proteins for cell-surface interaction with AβOs and identified a novel interaction between neurexins (NRXs) and AβOs. AβOs bind to NRXs via the N-terminal histidine-rich domain (HRD) of β-NRX1/2/3 and alternatively-spliced inserts at splicing site 4 of NRX1/2. In artificial synapse-formation assays, AβOs diminish excitatory presynaptic differentiation induced by NRX-interacting proteins including neuroligin1/2 (NLG1/2) and the leucine-rich repeat transmembrane protein LRRTM2. Although AβOs do not interfere with the binding of NRX1β to NLG1 or LRRTM2, time-lapse imaging revealed that AβO treatment reduces surface expression of NRX1β on axons and that this reduction depends on the NRX1β HRD. In transgenic mice expressing mutated human amyloid precursor protein, synaptic expression of β-NRXs, but not α-NRXs, decreases. Thus our data indicate that AβOs interact with NRXs and that this interaction inhibits NRX-mediated presynaptic differentiation by reducing surface expression of axonal β-NRXs, providing molecular and mechanistic insights into how AβOs lead to synaptic pathology in AD.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Naito Y,Tanabe Y,Lee AK,Hamel E,Takahashi H

doi

10.1038/srep42548

subject

Has Abstract

pub_date

2017-02-13 00:00:00

pages

42548

issn

2045-2322

pii

srep42548

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Drug treatment efficiency depends on the initial state of activation in nonlinear pathways.

    abstract：:An accurate prediction of the outcome of a given drug treatment requires quantitative values for all parameters and concentrations involved as well as a detailed characterization of the network of interactions where the target molecule is embedded. Here, we present a high-throughput in silico screening of all potentia...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30913-9

    authors： Doldán-Martelli V,Míguez DG

    更新日期：2018-08-21 00:00:00

  • Limb proportions show developmental plasticity in response to embryo movement.

    abstract：:Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical loading resulting from embryo movement. We tested the hypothesis that ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41926

    authors： Pollard AS,Charlton BG,Hutchinson JR,Gustafsson T,McGonnell IM,Timmons JA,Pitsillides AA

    更新日期：2017-02-06 00:00:00

  • Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection.

    abstract：:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11276-z

    authors： Rox K,Jansen R,Loof TG,Gillen CM,Bernecker S,Walker MJ,Chhatwal GS,Müller R

    更新日期：2017-09-18 00:00:00

  • Rapid histopathological imaging of skin and breast cancer surgical specimens using immersion microscopy with ultraviolet surface excitation.

    abstract：:Rapid histopathological evaluation of fresh, unfixed human tissue using optical sectioning microscopy would have applications to intraoperative surgical margin assessment. Microscopy with ultraviolet surface excitation (MUSE) is a low-cost optical sectioning technique using ultraviolet illumination which limits fluore...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22264-2

    authors： Yoshitake T,Giacomelli MG,Quintana LM,Vardeh H,Cahill LC,Faulkner-Jones BE,Connolly JL,Do D,Fujimoto JG

    更新日期：2018-03-14 00:00:00

  • Nano-scale depth-varying recrystallization of oblique Ar+ sputtered Si(111) layers.

    abstract：:Silicon, the workhorse of semiconductor industry, is being exploited for various functional applications in numerous fields of nanotechnology. In this paper, we report the fabrication of depth controllable amorphous silicon (a-Si) layers under 80 keV Ar+ ion sputtering at off-normal ion incidences of 30°, 40° and 50° ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68873-8

    authors： Gupta D,Umapathy GR,Singhal R,Ojha S,Aggarwal S

    更新日期：2020-07-17 00:00:00

  • Tunable Open Circuit Voltage by Engineering Inorganic Cesium Lead Bromide/Iodide Perovskite Solar Cells.

    abstract：:Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20228-0

    authors： Ng CH,Ripolles TS,Hamada K,Teo SH,Lim HN,Bisquert J,Hayase S

    更新日期：2018-02-06 00:00:00

  • Optical Absorption Exhibits Pseudo-Direct Band Gap of Wurtzite Gallium Phosphide.

    abstract：:Definitive evidence for the direct band gap predicted for Wurtzite Gallium Phosphide (WZ GaP) nanowires has remained elusive due to the lack of strong band-to-band luminescence in these materials. In order to circumvent this problem, we successfully obtained large volume WZ GaP structures grown by nanoparticle-crawlin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64809-4

    authors： da Silva BC,Couto ODD Jr,Obata HT,de Lima MM,Bonani FD,de Oliveira CE,Sipahi GM,Iikawa F,Cotta MA

    更新日期：2020-05-13 00:00:00

  • Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma.

    abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been implicated in cancer biogenesis and prognosis. By repurposing microarray probes, we herein analysed the lncRNA expression...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33535

    authors： Fu XL,Liu DJ,Yan TT,Yang JY,Yang MW,Li J,Huo YM,Liu W,Zhang JF,Hong J,Hua R,Chen HY,Sun YW

    更新日期：2016-09-15 00:00:00

  • Stable and discriminating features are predictive of cancer presence and Gleason grade in radical prostatectomy specimens: a multi-site study.

    abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33026-5

    authors： Leo P,Elliott R,Shih NNC,Gupta S,Feldman M,Madabhushi A

    更新日期：2018-10-08 00:00:00

  • Lysing bloom-causing alga Phaeocystis globosa with microbial algicide: An efficient process that decreases the toxicity of algal exudates.

    abstract：:Algicidal microbes could effectively remove the harmful algae from the waters. In this study, we were concerned with the ecological influence of an algicide extracted from Streptomyces alboflavus RPS, which could completely lyse the Phaeocystis globosa cells within two days. In microcosms, 4 μg/mL of the microbial alg...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20081

    authors： Cai G,Yang X,Lai Q,Yu X,Zhang H,Li Y,Chen Z,Lei X,Zheng W,Xu H,Zheng T

    更新日期：2016-02-05 00:00:00

  • Co-blending modification of activated coke using pyrolusite and titanium ore for low-temperature NOx removal.

    abstract：:Activated coke (AC) has great potential in the field of low-temperature NO removal (DeNOx), especially the branch prepared by blending modification. In this study, the AC-based pyrolusite and/or titanium ore blended catalysts were prepared and applied for DeNOx. The results show blending pyrolusite and titanium ore pr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76592-3

    authors： Yang L,Yao L,Lai Y,Jiang X,Jiang W

    更新日期：2020-11-10 00:00:00

  • A set of composite, non-redundant EEG measures of NREM sleep based on the power law scaling of the Fourier spectrum.

    abstract：:Features of sleep were shown to reflect aging, typical sex differences and cognitive abilities of humans. However, these measures are characterized by redundancy and arbitrariness. Our present approach relies on the assumptions that the spontaneous human brain activity as reflected by the scalp-derived electroencephal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81230-7

    authors： Bódizs R,Szalárdy O,Horváth C,Ujma PP,Gombos F,Simor P,Pótári A,Zeising M,Steiger A,Dresler M

    更新日期：2021-01-21 00:00:00

  • Structure-Property-Function Relationship in Humic Substances to Explain the Biological Activity in Plants.

    abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20798

    authors： García AC,de Souza LG,Pereira MG,Castro RN,García-Mina JM,Zonta E,Lisboa FJ,Berbara RL

    更新日期：2016-02-10 00:00:00

  • Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.

    abstract：:Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01843

    authors： Wang J,Qi J,Zhao H,He S,Zhang Y,Wei S,Zhao F

    更新日期：2013-01-01 00:00:00

  • Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy.

    abstract：:Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46488-y

    authors： Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

    更新日期：2019-07-15 00:00:00

  • Radiofrequency treatment alters cancer cell phenotype.

    abstract：:The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malign...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12083

    authors： Ware MJ,Tinger S,Colbert KL,Corr SJ,Rees P,Koshkina N,Curley S,Summers HD,Godin B

    更新日期：2015-07-13 00:00:00

  • Spirulina-templated metal microcoils with controlled helical structures for THz electromagnetic responses.

    abstract：:Microstructures in nature are ultrafine and ordered in biological roles, which have attracted material scientists. Spirulina forms three-dimensional helical microstructure, one of remarkable features in nature beyond our current processing technology such as lithography in terms of mass-productivity and structural mul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04919

    authors： Kamata K,Piao Z,Suzuki S,Fujimori T,Tajiri W,Nagai K,Iyoda T,Yamada A,Hayakawa T,Ishiwara M,Horaguchi S,Belay A,Tanaka T,Takano K,Hangyo M

    更新日期：2014-05-12 00:00:00

  • Internal surface electric charge characterization of mesoporous silica.

    abstract：:Mesoporous silica is an emerging technology to solve problems of existing and to support projected revolutionary applications ranging from targeted drug delivery to artificial kidney. However, one of the major driving mechanisms, electric charging of internal mesoporous surfaces, has not been characterized yet. In the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36487-w

    authors： Sen T,Barisik M

    更新日期：2019-01-15 00:00:00

  • Mechanistic insight into the functional transition of the enzyme guanylate kinase induced by a single mutation.

    abstract：:Dramatic functional changes of enzyme usually require scores of alterations in amino acid sequence. However, in the case of guanylate kinase (GK), the functional novelty is induced by a single (S→P) mutation, leading to the functional transition of the enzyme from a phosphoryl transfer kinase into a phosphorprotein in...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08405

    authors： Zhang Y,Niu H,Li Y,Chu H,Shen H,Zhang D,Li G

    更新日期：2015-02-12 00:00:00

  • Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation.

    abstract：:The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted Holistic Atom Localization and Entity Shape (WHALES) ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34677-0

    authors： Grisoni F,Merk D,Byrne R,Schneider G

    更新日期：2018-11-07 00:00:00

  • Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza.

    abstract：:Jasmonates (JAs) are plant-specific key signaling molecules that respond to various stimuli and are involved in the synthesis of secondary metabolites. However, little is known about the JA signal pathway, especially in economically significant medicinal plants. To determine the functions of novel genes that participa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14048

    authors： Ge Q,Zhang Y,Hua WP,Wu YC,Jin XX,Song SH,Wang ZZ

    更新日期：2015-09-21 00:00:00

  • High-throughput Identification and Characterization of Two-dimensional Materials using Density functional theory.

    abstract：:We introduce a simple criterion to identify two-dimensional (2D) materials based on the comparison between experimental lattice constants and lattice constants mainly obtained from Materials-Project (MP) density functional theory (DFT) calculation repository. Specifically, if the relative difference between the two la...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05402-0

    authors： Choudhary K,Kalish I,Beams R,Tavazza F

    更新日期：2017-07-12 00:00:00

  • Quantifying quantum coherence with quantum Fisher information.

    abstract：:Quantum coherence is one of the old but always important concepts in quantum mechanics, and now it has been regarded as a necessary resource for quantum information processing and quantum metrology. However, the question of how to quantify the quantum coherence has just been paid the attention recently (see, e.g., Bau...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15323-7

    authors： Feng XN,Wei LF

    更新日期：2017-11-14 00:00:00

  • Continuously Adjustable, Molecular-Sieving "Gate" on 5A Zeolite for Distinguishing Small Organic Molecules by Size.

    abstract：:Zeolites/molecular sieves with uniform, molecular-sized pores are important for many adsorption-based separation processes. Pore size gaps, however, exist in the current zeolite family. This leads to a great challenge of separating molecules with size differences at ~0.01 nm level. Here, we report a novel concept, por...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13981

    authors： Song Z,Huang Y,Xu WL,Wang L,Bao Y,Li S,Yu M

    更新日期：2015-09-11 00:00:00

  • MTFMT deficiency correlates with reduced mitochondrial integrity and enhanced host susceptibility to intracellular infection.

    abstract：:Mitochondria behave as functional and structural hubs for innate defense against intracellular infection. While the mitochondrial membrane serves as a platform for the assembly of signaling complexes activated by intracellular infection, various danger molecules derived from impaired mitochondria activate innate signa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68053-8

    authors： Seo JH,Hwang CS,Yoo JY

    更新日期：2020-07-07 00:00:00

  • Publisher Correction: Femtosecond laser fabrication of silver nanostructures on glass for surface enhanced Raman spectroscopy.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-59779-6

    authors： MacKenzie M,Chi H,Varma M,Pal P,Kar A,Paterson L

    更新日期：2020-03-16 00:00:00

  • IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration.

    abstract：:Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular matrix (ECM) proteins in the disc are the leading factors contribu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04384-3

    authors： Wang S,Liu C,Sun Z,Yan P,Liang H,Huang K,Li C,Tian J

    更新日期：2017-06-23 00:00:00

  • Global warming not so harmful for all plants - response of holomycotrophic orchid species for the future climate change.

    abstract：:Current and expected changes in global climate are major threat for biological diversity affecting individuals, communities and ecosystems. However, there is no general trend in the plants response to the climate change. The aim of present study was to evaluate impact of the future climate changes on the distribution ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13088-7

    authors： Kolanowska M,Kras M,Lipińska M,Mystkowska K,Szlachetko DL,Naczk AM

    更新日期：2017-10-05 00:00:00

  • Author Correction: Lithospheric mantle buoyancy: the role of tectonic convergence and mantle composition.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-57833-x

    authors： Boonma K,Kumar A,Garcia-Castellanos D,Jiménez-Munt I,Fernández M

    更新日期：2020-01-15 00:00:00

  • Patterning Graphene Film by Magnetic-assisted UV Ozonation.

    abstract：:Developing an alternative method for fabricating microscale graphene patterns that overcomes the obstacles of organic contamination, linewidth resolution, and substrate damaging is paramount for applications in optoelectronics. Here we propose to pattern chemical vapor deposition grown graphene film through a stencil ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46583

    authors： Wu Y,Tao H,Su S,Yue H,Li H,Zhang Z,Ni Z,Chen X

    更新日期：2017-04-19 00:00:00