Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro.

abstract：:Recent studies have indicated that different post-translational modifications (PTMs) synergistically orchestrate specific biological processes by crosstalks. However, the preference of the crosstalk among different PTMs and the evolutionary constraint on the PTM crosstalk need further dissections. In this study, the i...

journal_title：Scientific reports

authors： Pan Z,Liu Z,Cheng H,Wang Y,Gao T,Ullah S,Ren J,Xue Y

更新日期：2014-12-05 00:00:00

abstract：:Maternal gene products deposited in the egg regulate early embryogenesis before activation of the embryonic genome in animals. While in higher plants, it is believed that genes of parental origin contribute to early embryogenesis. However, little is known regarding the particular processes in which genes of parental o...

journal_title：Scientific reports

authors： Luo A,Zhao P,Zhang LY,Sun MX

更新日期：2016-07-19 00:00:00

abstract：:Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell dea...

journal_title：Scientific reports

authors： Zhang P,Fu C,Hu Y,Dong C,Song Y,Song E

更新日期：2015-03-20 00:00:00

abstract：:p-Alkoxyphenols (AOPs) are a class of ethers that are widely used in industrial and agricultural productions and daily necessities. p-Phenoxyphenol (PhOP) and p-pentyloxyphenol (PeOP) belong to this class and have been reported to be estrogenic in vitro. However, their in vivo estrogenic activities have rarely been of...

journal_title：Scientific reports

authors： Wang Y,Xiao H,Yang L,Jia X,Guo X,Zhang Z

更新日期：2020-10-14 00:00:00

abstract：:All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...

journal_title：Scientific reports

authors： Domínguez-Rodrigo M,Baquedano E

更新日期：2018-04-10 00:00:00

abstract：:Powdered activated carbon (AC) is commonly used as an effective additive to enhance anaerobic digestion (AD), but little is known about how the metabolic pathways resulting from adding AC change the microbial association network and enhance food waste treatment. In this work, the use of AC in an anaerobic digestion sy...

journal_title：Scientific reports

authors： Zhang J,Mao L,Zhang L,Loh KC,Dai Y,Tong YW

更新日期：2017-09-12 00:00:00

abstract：:Radix Astragali is commonly used in traditional Chinese medicine, and its quality is closely related to ecological factors, such as climate and soil, in the production area. To provide high-quality Radix Astragali to Chinese and foreign markets, we used maximum entropy model and statistical analysis method, combined w...

journal_title：Scientific reports

authors： Yang M,Li Z,Liu L,Bo A,Zhang C,Li M

更新日期：2020-07-27 00:00:00

abstract：:A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...

journal_title：Scientific reports

authors： Kim H,Choi MS,Inn KS,Kim BJ

更新日期：2016-07-01 00:00:00

abstract：:Sea ice is an important component of the global climate system and a key indicator of climate change. A decreasing trend in Arctic sea-ice concentration is evident in recent years, whereas Antarctic sea-ice concentration exhibits a generally increasing trend. Various studies have investigated the underlying causes of ...

journal_title：Scientific reports

authors： Yu L,Zhong S,Winkler JA,Zhou M,Lenschow DH,Li B,Wang X,Yang Q

更新日期：2017-04-05 00:00:00

abstract：:To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologi...

journal_title：Scientific reports

authors： Ægidius HM,Veidal SS,Feigh M,Hallenborg P,Puglia M,Pers TH,Vrang N,Jelsing J,Kornum BR,Blagoev B,Rigbolt KTG

更新日期：2020-01-24 00:00:00

abstract：:Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapid and noninvasive assessment...

journal_title：Scientific reports

authors： Alan G,Guenancia C,Arnould L,Azemar A,Pitois S,Maza M,Bichat F,Zeller M,Gabrielle PH,Bron AM,Creuzot-Garcher C,Cottin Y

更新日期：2019-05-30 00:00:00

abstract：:Daily music experience involves synchronizing movements in time with a perceived periodic beat. It has been established for over a century that beat synchronization is less stable for the visual than for the auditory modality. This auditory advantage of beat synchronization gives rise to the hypotheses that the neural...

journal_title：Scientific reports

authors： Gan L,Huang Y,Zhou L,Qian C,Wu X

更新日期：2015-07-07 00:00:00

abstract：:It is shown that in the ergodic regime, the temperature dependence of Young's modulus is solely determined by the magnetic properties of a material. For the large class of materials with paramagnetic or diamagnetic response, simple functional forms of the temperature derivative of Young's modulus are derived and compa...

journal_title：Scientific reports

authors： Binek C

更新日期：2017-07-07 00:00:00

abstract：:The Italian hare (Lepus corsicanus) is endemic to Central-Southern Italy and Sicily, classified as vulnerable due to habitat alterations, low density and fragmented populations and ecological competition with the sympatric European hare (Lepus europaeus). Despite this status, only few and local studies have explored i...

journal_title：Scientific reports

authors： Buglione M,Petrelli S,de Filippo G,Troiano C,Rivieccio E,Notomista T,Maselli V,di Martino L,Carafa M,Gregorio R,Latini R,Fortebraccio M,Romeo G,Biliotti C,Fulgione D

更新日期：2020-08-04 00:00:00

abstract：:Schizotypy is associated with poor emotion regulation that is thought to contribute to the development of psychotic symptoms and to indicate a predisposition to schizophrenia. Having focused primarily on the relationship between schizotypy and explicit emotion regulation, existing studies have, until now, neglected to...

journal_title：Scientific reports

authors： Hoid D,Pan DN,Wang Y,Li X

更新日期：2020-03-03 00:00:00

abstract：:In 2017-2019 a surge of Shispare Glacier, a former tributary of the once larger Hasanabad Glacier (Hunza region), dammed the proglacial river of Muchuhar Glacier, which formed an ice-dammed lake and generated a small Glacial Lake Outburst Flood (GLOF). Surge movement produced the highest recorded Karakoram glacier sur...

journal_title：Scientific reports

authors： Bhambri R,Watson CS,Hewitt K,Haritashya UK,Kargel JS,Pratap Shahi A,Chand P,Kumar A,Verma A,Govil H

更新日期：2020-03-13 00:00:00

abstract：:N-linked glycosylation is one of the predominant post-translational modifications involved in a number of biological functions. Since experimental characterization of glycosites is challenging, glycosite prediction is crucial. Several predictors have been made available and report high performance. Most of them evalua...

journal_title：Scientific reports

authors： Pitti T,Chen CT,Lin HN,Choong WK,Hsu WL,Sung TY

更新日期：2019-11-04 00:00:00

abstract：:We present a combined experimental and theoretical study of the electronic properties of close-spaced dangling-bond (DB) pairs in a hydrogen-passivated Si(001):H p-doped surface. Two types of DB pairs are considered, called "cross" and "line" structures. Our scanning tunneling spectroscopy (STS) data show that, althou...

journal_title：Scientific reports

authors： Engelund M,Zuzak R,Godlewski S,Kolmer M,Frederiksen T,García-Lekue A,Sánchez-Portal D,Szymonski M

更新日期：2015-09-25 00:00:00

abstract：:Metal oxides based graphene nanocomposites were used for ammonia vapour sensing. The self-assembly process was adopted to prepare freestanding flexible pure rGO, CeO2-rGO and SnO2-rGO composite papers. The structural studies confirmed the formation of rGO composite papers. The ammonia vapor sensing was demonstrated us...

journal_title：Scientific reports

authors： Selvakumar D,Sivaram H,Alsalme A,Alghamdi A,Jayavel R

更新日期：2019-06-19 00:00:00

abstract：:Stable isotope labeling is a standard technique for tracing material transfer in molecular, ecological and biogeochemical studies. The main assumption in this approach is that the enrichment with a heavy isotope has no effect on the organism metabolism and growth, which is not consistent with current theoretical and e...

journal_title：Scientific reports

authors： Andriukonis E,Gorokhova E

更新日期：2017-03-10 00:00:00

abstract：:Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated ...

journal_title：Scientific reports

authors： Bartley SN,Mowlaboccus S,Mullally CA,Stubbs KA,Vrielink A,Maiden MC,Harrison OB,Perkins TT,Kahler CM

更新日期：2017-03-14 00:00:00

abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

journal_title：Scientific reports

authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

更新日期：2020-07-03 00:00:00

abstract：:Sirtuins are NAD(+) dependent lysine deacylases involved in many regulatory processes such as control of metabolic pathways, DNA repair and stress response. Modulators of sirtuin activity are required as tools for uncovering the biological function of these enzymes and as potential therapeutic agents. Systematic disco...

journal_title：Scientific reports

authors： Schuster S,Roessler C,Meleshin M,Zimmermann P,Simic Z,Kambach C,Schiene-Fischer C,Steegborn C,Hottiger MO,Schutkowski M

更新日期：2016-03-04 00:00:00

abstract：:Visfatin/extracellular-nicotinamide-phosphoribosyltranferase-(eNampt) is a multifaceted adipokine enhanced in type-2-diabetes and obesity. Visfatin/eNampt cause in vitro endothelial dysfunction and vascular inflammation, although whether the same effects are achieved in vivo is unknown. Toll-like receptor-4 (TLR4), a ...

journal_title：Scientific reports

authors： Romacho T,Valencia I,Ramos-González M,Vallejo S,López-Esteban M,Lorenzo O,Cannata P,Romero A,San Hipólito-Luengo A,Gómez-Cerezo JF,Peiró C,Sánchez-Ferrer CF

更新日期：2020-03-25 00:00:00

abstract：:If a cultural feature is transmitted over generations and exposed to stochastic selection when spreading in a population, its evolution may be governed by statistical laws and be partly predictable, as in the case of genetic evolution. Music exhibits steady changes of styles over time, with new characteristics develop...

journal_title：Scientific reports

authors： Nakamura E,Kaneko K

更新日期：2019-11-05 00:00:00

abstract：:The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...

journal_title：Scientific reports

authors： Lu M,Yan H,Yu C,Yuan L,Sun S

更新日期：2020-01-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Yu C,Li T,Zhang R,Yang X,Yang Z,Xin L,Zhao Z

更新日期：2020-04-29 00:00:00

abstract：:Interactions between microalgae and bacteria are often obligatory for harmful algal blooms (HABs). Here, we investigated the specific bacterial communities associated with Alexandrium tamarense and Cochlodinium polykrikoides, which cause ecological and economic damage during their blooms. To this end, the bacterial me...

journal_title：Scientific reports

authors： Shin H,Lee E,Shin J,Ko SR,Oh HS,Ahn CY,Oh HM,Cho BK,Cho S

更新日期：2018-03-28 00:00:00

abstract：:There are many types of autoregressive patterns in financial time series, and they form a transmission process. Here, we define autoregressive patterns quantitatively through an econometrical regression model. We present a computational algorithm that sets the autoregressive patterns as nodes and transmissions between...

journal_title：Scientific reports

authors： Gao X,An H,Fang W,Huang X,Li H,Zhong W

更新日期：2014-09-05 00:00:00

abstract：:Bloodstain Pattern Analysis is a forensic discipline in which, among others, the position of victims can be determined at crime scenes on which blood has been shed. To determine where the blood source was investigators use a straight-line approximation for the trajectory, ignoring effects of gravity and drag and thus ...

journal_title：Scientific reports

authors： Laan N,de Bruin KG,Slenter D,Wilhelm J,Jermy M,Bonn D

更新日期：2015-06-22 00:00:00