Abstract:
:The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in a high dose, respectively. This study aimed to determine the interactions of common clinically proton pump inhibitors (PPIs) and fluconazole both in vitro and in vivo and to further explore the possible mechanisms. In vitro, the tested PPIs all acted synergistically with fluconazole against both resistant C. albicans planktonic cells and biofilms preformed for ≤12 h with the minimum inhibitory concentration of fluconazole decreased from >512 μg/mL to 1-4 μg/mL. In vivo, PPIs plus fluconazole prolonged the survival rate of infected Galleria mellonella larvae by two-fold compared with that for the fluconazole monotherapy group and significantly reduced the tissue damage of infected larvae. Mechanism studies showed that PPIs significantly suppressed efflux pump activity, which is the common resistance mechanism of C. albicans, and significantly inhibited the virulence factors: phospholipase activity and morphology switching. These findings will provide new insights into antifungal agent discovery and potential approaches for the treatment of candidiasis caused by resistant C. albicans.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lu M,Yan H,Yu C,Yuan L,Sun Sdoi
10.1038/s41598-019-57174-4subject
Has Abstractpub_date
2020-01-16 00:00:00pages
498issue
1issn
2045-2322pii
10.1038/s41598-019-57174-4journal_volume
10pub_type
杂志文章abstract::Spermatogenesis in the mouse has been extensively studied for decades. Previous methods, such as histological staining or bulk transcriptome analysis, either lacked resolution at the single-cell level or were focused on a very narrowly defined set of factors. Here, we present the first comprehensive, unbiased single-c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24725-0
更新日期:2018-04-25 00:00:00
abstract::Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in repr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34788
更新日期:2016-10-10 00:00:00
abstract::Tuberculosis (TB) is a leading infectious cause of death globally. Drug treatment and vaccination, in particular with Bacillus Calmette-Guérin (BCG), remain the main strategies to control TB. With the emergence of drug resistance, it has been proposed that a combination of TB vaccination with pharmacological treatment...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41008-4
更新日期:2019-03-19 00:00:00
abstract::The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48331-w
更新日期:2019-08-15 00:00:00
abstract::When individuals breed more than once, parents are faced with the choice of whether to re-mate with their old partner or divorce and select a new mate. Evolutionary theory predicts that, following successful reproduction with a given partner, that partner should be retained for future reproduction. However, recent wor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72521-6
更新日期:2020-09-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59906-3
更新日期:2020-02-13 00:00:00
abstract::Intelligent development is an inevitable choice for the green development of manufacturing enterprises, environmental regulations and green innovation play an important role in the intelligent development of manufacturing enterprises. By analyzing the interrelationships between environmental regulations, green innovat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71423-x
更新日期:2020-09-02 00:00:00
abstract::Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and response to therap...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-49952-x
更新日期:2019-09-17 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44354-5
更新日期:2019-05-23 00:00:00
abstract::During the last decades, atmospheric nitrogen loading in mountain ranges of the Northern Hemisphere has increased substantially, resulting in high nitrate concentrations in many lakes. Yet, how increased nitrogen has affected denitrification, a key process for nitrogen removal, is poorly understood. We measured actual...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59759-w
更新日期:2020-02-20 00:00:00
abstract::Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives may antagonize these actions. The effect of three antagonists, tetraiodoacetic a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16593-x
更新日期:2017-11-28 00:00:00
abstract::Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymethylcytosine, with loss of 5 hmC as an epigenetic hallmark of cancers, indicating critical roles of TET proteins in epigenetic tumorigenesis. Through analy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26591
更新日期:2016-05-26 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43188
更新日期:2017-02-23 00:00:00
abstract::Fairly poor data are available on the relationship between taste perception, food preferences and oral microbiota. In the present study, we investigated the hypothesis that subjects with higher responsiveness to 6-n-propylthiuracil (PROP) might be characterized by a different taste sensitivity and tongue microbiota co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40374-3
更新日期:2019-03-05 00:00:00
abstract::Sea surface temperature (SST) patterns can - as surface climate forcing - affect weather and climate at large distances. One example is El Niño-Southern Oscillation (ENSO) that causes climate anomalies around the globe via teleconnections. Although several studies identified and characterized these teleconnections, ou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45423-5
更新日期:2019-06-19 00:00:00
abstract::High quality cadmium-free Zn-In-S:Ag doped-nanocrystals (d-NCs) were synthesized via a simple one-step noninjection route using silver nitrate, indium acetate, zinc acetate, oleylamine, S powder and 1-dodecanethiol as starting materials in an organic phase. The size and optical properties can be effectively tailored b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24459
更新日期:2016-04-14 00:00:00
abstract::In arid and semiarid regions, low precipitation rates lead to soil salinity problems, which may limit plant establishment, growth, and survival. Herein, we investigated the NaCl stress effect on chlorophyll fluorescence, photosynthetic-pigments, movement and chloroplasts ultrastructure in chlorenchyma cells of Opuntia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08744-x
更新日期:2017-08-17 00:00:00
abstract::A cell-type saturable absorber has been demonstrated by filling the single mode photonic crystal fiber (SMPCF) with tungsten disulfide (WS2) nanosheets. The modulation depth, saturable intensity, and non-saturable loss of this SA are measured to be 3.53%, 159 MW/cm(2) and 23.2%, respectively. Based on this SA, a passi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12587
更新日期:2015-07-27 00:00:00
abstract::There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subje...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32935
更新日期:2016-09-09 00:00:00
abstract::The Iberian Mediterranean Basin is home to one of the largest groups of prehistoric rock art sites in Europe. Despite the cultural relevance of prehistoric Spanish Levantine rock art, pigment composition remains partially unknown, and the nature of the binders used for painting has yet to be disclosed. In this work, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28121-6
更新日期:2018-07-03 00:00:00
abstract::Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23849-7
更新日期:2018-04-17 00:00:00
abstract::Serial 3-dimensional dental model superimposition provides a risk-free, detailed evaluation of morphological alterations on a patient's mouth. Here, we evaluated accuracy and precision of five palatal areas, used for superimposition of maxillary 3D digital dental casts. Sixteen pre- and post-orthodontic treatment dent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06013-5
更新日期:2017-07-19 00:00:00
abstract::A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32167
更新日期:2016-08-30 00:00:00
abstract::Magnetic materials have found wide application ranging from electronics and memories to medicine. Essential to these advances is the control of the magnetic order. To date, most room-temperature applications have a fixed magnetic moment whose orientation is manipulated for functionality. Here we demonstrate an iron-ox...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11430
更新日期:2015-06-23 00:00:00
abstract::The study aimed at investigating the extent to which the brain adaptively exploits or compensates interaction torque (IT) during movement control in various velocity and load conditions. Participants performed arm pointing movements toward a horizontal plane without a prescribed reach endpoint at slow, neutral and rap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38845
更新日期:2016-12-12 00:00:00
abstract::Elevated atmospheric CO2 concentrations are contributing to ocean acidification (reduced seawater pH and carbonate concentrations), with potentially major ramifications for marine ecosystems and their functioning. Using a novel in situ experiment we examined impacts of reduced seawater pH on Antarctic sea ice-associat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42329-0
更新日期:2019-04-15 00:00:00
abstract::Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 201...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36235
更新日期:2016-11-08 00:00:00
abstract::Video game play induces a generalized recovery of a range of spatial visual functions in the amblyopic brain. Here we ask whether video game play also alters temporal processing in the amblyopic brain. When visual targets are presented in rapid succession, correct identification of the first target (T1) can interfere ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08483
更新日期:2015-02-26 00:00:00
abstract::Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80031-8
更新日期:2021-01-08 00:00:00
abstract::Among the bacterial symbionts harbored by the model organism Paramecium, many still lack a recent investigation that includes a molecular characterization. The genus Lyticum consists of two species of large-sized bacteria displaying numerous flagella, despite their inability to move inside their hosts' cytoplasm. We p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03305
更新日期:2013-11-22 00:00:00