Abstract：
:Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the association of the SRGAP2 rs2483058 and rs2580520 SNPs and their haplotypes with serum lipid traits in the Maonan and Han populations. Genotyping of the 2 SNPs was performed in 2444 unrelated subjects (Han, 1210 and Maonan, 1234) by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing. The allelic (rs2483058) and genotypic (rs2483058 and rs2580520) frequencies were different between the two ethnic groups. Four haplotypes were identified in our populations, and the rs2483058G-rs2580520C haplotype was the commonest one. The rs2483058C-rs2580520G haplotype was associated with an increased risk of dyslipidemia, and showed consistent association with serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1 levels, and the ApoA1/ApoB ratio. These results indicated that the SRGAP2 SNPs and their haplotypes were associated with serum lipid levels. Their haplotypes can explain much more serum lipid variation than any single SNP alone, especially for serum TC, HDL-C and ApoA1 levels.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Miao L,Yin RX,Wu JZ,Yang S,Lin WX,Pan SLdoi
10.1038/s41598-017-10950-6subject
Has Abstractpub_date
2017-09-14 00:00:00pages
11626issue
1issn
2045-2322pii
10.1038/s41598-017-10950-6journal_volume
7pub_type
杂志文章abstract：:We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas. We define the knowledge diffusion proxy, and scientific production ranking algorithms to capture the spatio-temporal dynamics of Physics know...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01640
更新日期：2013-01-01 00:00:00
abstract：:Mixed species biofilms are shaped and influenced by interactions between species. In the oral cavity, dysbiosis of the microbiome leads to diseases such as periodontitis. Porphyromonas gingivalis is a keystone pathogen of periodontitis. In this study, we showed that polymicrobial biofilm formation promoted the toleran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41467-9
更新日期：2019-03-20 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In this study, treatment with either of two BMP inhibitors reduced hepa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66770-8
更新日期：2020-06-19 00:00:00
abstract：:The capture and activation of individual T cells on functionalised surfaces enables real-time analyses of the magnitude and rhythm of intracellular calcium release. Application of Haarlet transformations generate a calcium flux 'threshold', with the frequency of the 'threshold crossings' correlating with the strength ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07760
更新日期：2015-01-14 00:00:00
abstract：:Seagrass meadows are threatened by coastal development and global change. In the face of these pressures, molecular techniques such as reverse transcription quantitative real-time PCR (RT-qPCR) have great potential to improve management of these ecosystems by allowing early detection of chronic stress. In RT-qPCR, the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17051
更新日期：2015-11-23 00:00:00
abstract：:Natural products with a sulfated scaffold have emerged as antifouling agents with low or nontoxic effects to the environment. In this study 13 sulfated polyphenols were synthesized and tested for antifouling potential using the anti-settlement activity of mussel (Mytilus galloprovincialis) plantigrade post-larvae and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42424
更新日期：2017-02-13 00:00:00
abstract：:Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular domains to understan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39905-9
更新日期：2019-03-06 00:00:00
abstract：:Breast cancer is the leading cause of cancer death among women worldwide. Like other cancers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an important factor for cancer detection and treatment strategies. However, the effects of acidity on mammary carcinoma cell morphol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78989-6
更新日期：2020-12-15 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23087-x
更新日期：2018-03-19 00:00:00
abstract：:Dengue virus (DENV) co-circulation in Brazil represents a challenge for treatment and vaccine development. Despite public health impact, the occurrence of coinfections with other viruses is a common event. Increased T cell activation and altered inflammatory response are found during DENV coinfection with Human Immuno...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62776-4
更新日期：2020-04-14 00:00:00
abstract：:Low level light therapy receives increasing interest in the fields of tissue regeneration and wound healing. Several in vivo studies demonstrated the positive effects of LLLT on angiogenesis. This study aimed to investigate the underlying properties in vitro by comparing the effects of light therapy by light emitting ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11061-y
更新日期：2017-09-06 00:00:00
abstract：:Recreational boating is an increasing activity in coastal areas and its spatiotemporal overlap with key habitats of marine species pose a risk for negative noise impacts. Yet, recreational vessels are currently unaccounted for in vessel noise models using Automatic Identification System (AIS) data. Here we conduct a c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51222-9
更新日期：2019-10-29 00:00:00
abstract：:The discovery of the community structure of real-world networks is still an open problem. Many methods have been proposed to shed light on this problem, and most of these have focused on discovering node community. However, link community is also a powerful framework for discovering overlapping communities. Here we pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22470
更新日期：2016-03-01 00:00:00
abstract：:The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17128
更新日期：2015-11-25 00:00:00
abstract：:We herein report that supported copper nanoparticles (CuNPs) on commercially available controlled pore glass (CPG), which exhibit high mechanical, thermal and chemical stability as compared to other silica-based materials, serve as a useful heterogeneous catalyst system for 1,3-dipolar cycloadditions ("click" reaction...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77629-3
更新日期：2020-11-25 00:00:00
abstract：:A multi-agent Parrondo's model based on complex networks is used in the current study. For Parrondo's game A, the individual interaction can be categorized into five types of behavioral patterns: the Matthew effect, harmony, cooperation, poor-competition-rich-cooperation and a random mode. The parameter space of Parro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37028
更新日期：2016-11-15 00:00:00
abstract：:Terrestrial microbial ecosystems are exposed to many types of disturbances varying in their spatial and temporal characteristics. The ability to cope with these disturbances is crucial for maintaining microbial ecosystem functions, especially if disturbances recur regularly. Thus, understanding microbial ecosystem dyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27785-4
更新日期：2018-06-22 00:00:00
abstract：:KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22600-6
更新日期：2018-03-09 00:00:00
abstract：:We propose the realization of photonic circuits whose dynamics is governed by advanced-retarded differential equations. Beyond their mathematical interest, these photonic configurations enable the implementation of quantum feedback and feedforward without requiring any intermediate measurement. We show how this protoc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42933
更新日期：2017-02-23 00:00:00
abstract：:Cytomegalovirus (CMV) is one of the infectious causes of hypertensive anterior uveitis, which is characterized by recurrent episodes of elevated intraocular pressure (IOP) and mild anterior uveitis. Despite the potentially vision-threatening complications of this disease, the underlying mechanisms remain largely undef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43349
更新日期：2017-02-27 00:00:00
abstract：:We previously developed red lettuce (Lactuca sativa L.) cultivars with high flavonoid and phenolic acid content and demonstrated their anti-diabetic effect. Here we report on developing three fertile and true-breeding lettuce lines enriched with flavonoids with reported beneficial health effects. These lines were iden...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39287-y
更新日期：2019-03-01 00:00:00
abstract：:A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative malignancies developed from mature B cells. Reproducing a proliferative stimulation ex vivo is critical to decipher the mechanisms of leukemogenesis in these maligna...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36853-8
更新日期：2019-01-24 00:00:00
abstract：:Transparent heaters have attracted increasing attention for their usefulness in vehicle windows, outdoor displays, and periscopes. We present high performance transparent heaters based on Ag nanowires with electron beam irradiation. We obtained an Ag-nanowire thin film with 48 ohm/sq of sheet resistance and 88.8% (sub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17716
更新日期：2015-12-07 00:00:00
abstract：:Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02560-z
更新日期：2017-06-01 00:00:00
abstract：:Inflammation is considered as a major contributor to brain injury following cerebral ischemia. The therapeutic potential of both MLC601/MLC901, which are herbal extract preparations derived from Chinese Medicine, has been reported both in advanced stroke clinical trials and also in animal and cellular models. The aim ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36138-0
更新日期：2018-12-24 00:00:00
abstract：:The distribution of corals in Japan covers a wide range of latitudes, encompassing tropical to temperate zones. However, coral communities in temperate zones contain only a small subset of species. Among the parameters that determine the distribution of corals, temperature plays an important role. We tested the resili...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18467
更新日期：2015-12-18 00:00:00
abstract：:Patterns of temperature fluctuations in nature affect numerous biological processes, yet, empirical studies often utilize constant temperature treatments. This can limit our understanding of how thermally sensitive species respond to ecologically relevant temperatures. Research on turtles with temperature-dependent se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17708-0
更新日期：2018-01-08 00:00:00
abstract：:Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15660
更新日期：2015-10-22 00:00:00
abstract：:We propose a new efficient algorithm to simulate magnetic structures numerically. It contains a generative model using a complex-valued neural network to generate k-space information. The output information is hermitized and transformed into real-space spin configurations through an inverse fast Fourier transform. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53411-y
更新日期：2019-11-13 00:00:00
abstract：:Junction-less nanowire transistors are being investigated to solve short channel effects in future CMOS technology. Here we demonstrate 8 nm diameter silicon nanowire junction-less transistors with metallic doping densities which demonstrate clear 1D electronic transport characteristics. The 1D regime allows excellent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03138-5
更新日期：2017-06-07 00:00:00
