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Apoptosis characterization in mononuclear blood leukocytes of HIV patients during dengue acute disease.

Abstract：

:Dengue virus (DENV) co-circulation in Brazil represents a challenge for treatment and vaccine development. Despite public health impact, the occurrence of coinfections with other viruses is a common event. Increased T cell activation and altered inflammatory response are found during DENV coinfection with Human Immunodeficiency Virus (HIV) impacting HIV-pathogenesis. Even with Antiretroviral therapy (ART), HIV- treated patients had chronic immune activation and lymphocyte apoptosis. However, apoptotic mechanisms have not been investigated during coinfection with DENV. Our attention was attracted to apoptotic cell markers expressions in PBMCs from DENV and DENV/HIV coinfected patients. We found CD4/CD8 ratio inversion in most coinfected patients. CD4 T and CD8 T-cell subsets from DENV and DENV/HIV groups expressed low levels of anti-apoptotic protein Bcl-2. Furthermore, CD8 CD95 double positive cells frequency expressing low levels of Bcl-2 were significantly higher in these patients. Additionally, the density of Bcl-2 on classical monocytes (CD14++CD16-) was significantly lower during DENV infection. Upregulation of pro-apoptotic proteins and anti-apoptotic proteins were found in DENV and DENV/HIV, while catalase, an antioxidant protein, was upregulated mainly in DENV/HIV coinfection. These findings provide evidence of apoptosis triggering during DENV/HIV coinfection, which may contribute to knowledge of immunological response during DENV acute infection in HIV-patients treated with ART.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Torrentes-Carvalho A,Sánchez-Arcila JC,Azamor T,Barbosa LS,Hottz ED,Gandini M,Bozza FA,da Cunha RV,de Oliveira Pinto LM,Damasco PV,de Azeredo EL

doi

10.1038/s41598-020-62776-4

subject

Has Abstract

pub_date

2020-04-14 00:00:00

pages

6351

issue

1

issn

2045-2322

pii

10.1038/s41598-020-62776-4

journal_volume

10

pub_type

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